Patents by Inventor Bertram Pitt

Bertram Pitt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230241076
    Abstract: Provided herein are agents that modulate histone acetylation and pathways downstream thereof, and methods for the treatment and prevention of organ injury therewith. In particular, provided herein are combinations of histone deacetylase (HDAC) inhibitors, bromodomain and extraterminal-containing protein family (BET) inhibitors, promoters of histone acetyl transferase (HAT) activity, mineralocorticoid receptor (MR) antagonists, nuclear factor erythroid 2-related factor 2 (NRF2) activators, and/or aldehyde dehydrogenase (ALDH) agonists, and methods of use thereof for the treatment and prevention of heart injury.
    Type: Application
    Filed: June 29, 2021
    Publication date: August 3, 2023
    Inventors: Yuqing E. Chen, Bertram Pitt, Ienglam Lei, Shuo Tian, Francis Pagani, Paul C. Tang, Zhong Wang
  • Patent number: 9931412
    Abstract: Provided herein is technology relating to theranostic agents and particularly, but not exclusively, to compositions comprising cell-specific theranostic agents and associated methods and systems for using the cell-specific theranostic agents to treat subjects.
    Type: Grant
    Filed: February 7, 2014
    Date of Patent: April 3, 2018
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Sascha N. Goonewardena, Bertram Pitt, Hong Zong
  • Publication number: 20140227297
    Abstract: Provided herein is technology relating to theranostic agents and particularly, but not exclusively, to compositions comprising cell-specific theranostic agents and associated methods and systems for using the cell-specific theranostic agents to treat subjects.
    Type: Application
    Filed: February 7, 2014
    Publication date: August 14, 2014
    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Sascha N. Goonewardena, Bertram Pitt, Hong Zong
  • Publication number: 20100034902
    Abstract: The present invention provides methods for measuring, detecting, diagnosing, treating, and researching salt sensitivity and related conditions. In particular, the present invention provides methods for measuring, detecting, diagnosing, treating, and researching salt sensitivity through measuring aberrant red blood cell based potassium efflux levels. In addition, the present invention provides methods for treating conditions involving salt sensitivity (e.g., hypertension), preventing the onset of conditions involving salt sensitivity, identifying individuals at risk for developing salt sensitivity and related conditions, identifying new types of treatment for salt sensitivity and related conditions, and evaluating the effectiveness of treatments for conditions involving salt sensitivity (e.g., hypertension).
    Type: Application
    Filed: January 17, 2008
    Publication date: February 11, 2010
    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Maria Carolina Delgado, Bertram Pitt
  • Publication number: 20100021879
    Abstract: The present invention provides methods, compositions and kits for storing red blood cells for extended periods of time. In particular, the present invention provides methods, compositions and kits for storing red blood cells for extended periods of time while preventing red blood cell storage lesions, retaining red blood cell deformability, and increasing survival of the red blood cells following transfusion.
    Type: Application
    Filed: January 17, 2008
    Publication date: January 28, 2010
    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Maria Carolina Delgado, Bertram Pitt
  • Publication number: 20080242659
    Abstract: The present invention is related to a method for reducing cardiovascular morbidity and/or mortality comprising administering a combination comprising an ACE inhibitor and a CCB, specifically benazapril and amlodipine besylate.
    Type: Application
    Filed: November 29, 2007
    Publication date: October 2, 2008
    Inventors: Kenneth Jamerson, Malcolm MacNab, Bertram Pitt
  • Publication number: 20060233876
    Abstract: The present invention is related to a method for reducing cardiovascular morbidity and/or mortality comprising administering a combination comprising an ACE inhibitor and a CCB, specifically benazapril and amlodipine besylate.
    Type: Application
    Filed: October 20, 2004
    Publication date: October 19, 2006
    Inventors: Kenneth Jamerson, Malcolm MacNab, Bertram Pitt
  • Patent number: 6201002
    Abstract: Angiotensin II receptor antagonists are useful in reducing and preventing mortality and sudden cardiac death in symptomatic heart failure patients. Losartan potassium has been shown to reduce mortality and sudden cardiac death in this patient population. Additionally, losartan potassium has been shown to reduce the need for hospitalization of symptomatic heart failure patients.
    Type: Grant
    Filed: January 6, 1998
    Date of Patent: March 13, 2001
    Assignee: Merck & Co., Inc.
    Inventors: Polly A. Beere, Paul I. Chang, Bertram Pitt, Eva J. Rucinska, Robert Segal, Divakar Sharma, Duane B. Snavely