Patents by Inventor Bertrand Heckmann

Bertrand Heckmann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7846932
    Abstract: A subject of the invention is the compounds of formula (I); in which R1, R2, R3, R4 and R have the meanings indicated in the description, their preparation process, their use as medicaments having an antagonist activity on the vitronectin receptor and the pharmaceutical compositions containing them.
    Type: Grant
    Filed: August 14, 2009
    Date of Patent: December 7, 2010
    Assignee: Galapagos SAS
    Inventors: Jean-Michel Lefrancois, Bertrand Heckmann
  • Patent number: 7825119
    Abstract: A subject of the invention is the compounds of formula (I): in which R1, R2, R3, R4 and R have the meanings indicated in the description, their preparation process, their use as medicaments having an antagonist activity on the vitronectin receptor and the pharmaceutical compositions containing them.
    Type: Grant
    Filed: May 13, 2005
    Date of Patent: November 2, 2010
    Assignee: Galapagos SAS
    Inventors: Jean-Michel Lefrancois, Bertrand Heckmann
  • Patent number: 7763621
    Abstract: A subject of the invention is the compounds of formula (I): in which R1, R2, R3, R4 and G have the meanings indicated in the description, their preparation process, their use as medicaments having an antagonist activity on the vitronectin receptor and the pharmaceutical compositions containing them.
    Type: Grant
    Filed: October 3, 2008
    Date of Patent: July 27, 2010
    Assignee: Galapagos SAS
    Inventors: Jean-Marie Ruxer, Jean-Michel Lefrancois, Bertrand Heckmann
  • Publication number: 20100041675
    Abstract: A subject of the invention is the compounds of formula (I); in which R1, R2, R3, R4 and R have the meanings indicated in the description, their preparation process, their use as medicaments having an antagonist activity on the vitronectin receptor and the pharmaceutical compositions containing them.
    Type: Application
    Filed: August 14, 2009
    Publication date: February 18, 2010
    Inventors: Jean-Michel Lefrancois, Bertrand Heckmann
  • Patent number: 7582640
    Abstract: A subject of the invention is the compounds of formula (I): in which R1, R2, R3, R4 and G have the meanings indicated in the description, their preparation process, their use as medicaments having an antagonist activity on the vitronectin receptor and the pharmaceutical compositions containing them.
    Type: Grant
    Filed: November 12, 2003
    Date of Patent: September 1, 2009
    Assignee: Galapagos SAS
    Inventors: Jean-Marie Ruxer, Jean-Michel Lefrancois, Bertrand Heckmann
  • Publication number: 20090149476
    Abstract: A subject of the invention is the compounds of formula (I): in which R1, R2, R3, R4 and G have the meanings indicated in the description, their preparation process, their use as medicaments having an antagonist activity on the vitronectin receptor and the pharmaceutical compositions containing them.
    Type: Application
    Filed: October 3, 2008
    Publication date: June 11, 2009
    Inventors: Jean-Marie Ruxer, Jean Michel Lefrancois, Bertrand Heckmann
  • Publication number: 20080058348
    Abstract: A subject of the invention is the compounds of formula (I); in which R1, R2, R3, R4 and R have the meanings indicated in the description, their preparation process, their use as medicaments having an antagonist activity on the vitronectin receptor and the pharmaceutical compositions containing them.
    Type: Application
    Filed: May 13, 2005
    Publication date: March 6, 2008
    Inventors: Jean-Michel Lefrancois, Bertrand Heckmann
  • Publication number: 20060052398
    Abstract: A subject of the invention is the compounds of formula (I): in which R1, R2, R3, R4 and G have the meanings indicated in the description, their preparation process, their use as medicaments having an antagonist activity on the vitronectin receptor and the pharmaceutical compositions containing them.
    Type: Application
    Filed: November 12, 2003
    Publication date: March 9, 2006
    Inventors: Jean-Marie Ruxer, Jean Lefrancois, Bertrand Heckmann
  • Patent number: 6313101
    Abstract: A compound of the formula wherein X=CH2 or NH, Y=H or Hal, Z=H or acyl of an organic carboxylic acid of 1 to 6 carbon atoms, R is W and W′ are individually H, Hal and alkyl of 1 to 8 carbon atoms optionally substituted by at least one halogen having antibiotic properties.
    Type: Grant
    Filed: February 3, 2000
    Date of Patent: November 6, 2001
    Assignee: Aventis Pharma S.A.
    Inventors: Alexis Denis, Claude Fromentin, Bertrand Heckmann
  • Patent number: 6143774
    Abstract: The invention relates to the new products of formula (I): ##STR1## in which: R.sub.1 represents alkyl, optionally substituted or cycloalkyl optionally interrupted by heteroatoms,R.sub.2 ; R.sub.3 both represent or carry an acid function or an acid isosteric function,and Y represents phenyl substituted in particular by a dioxol radical,these products being in all the isomeric forms and the salts, as medicaments.
    Type: Grant
    Filed: June 9, 1998
    Date of Patent: November 7, 2000
    Assignee: Hoechst Marion Roussel
    Inventors: Bertrand Heckmann, Simone Jouquey, Jean-Paul Vevert, Jidong Zhang
  • Patent number: 5986103
    Abstract: The invention relates to the new products of formula (I): ##STR1## in which: R.sub.1 represents alkyl,A represents a sulphur or oxygen atom,R.sub.2 represents carboxy, tetrazolyl or alkyl, alkoxy, alkylthio substituted by a carboxy or a tetrazolyl,Hal.sub.1 is halogen, q represents an integer from 0 to 4,R.sub.3 is formyl, carboxy or tetrazolyl,Y represents phenyl substituted by a dioxol radical and optionally by a halogen atom, or by an alkyl or alkoxy radicalas well as all the possible racemic, enantiomeric and diastereoisomeric isomer forms, as well as the addition salts of said products of formula (I).
    Type: Grant
    Filed: June 9, 1998
    Date of Patent: November 16, 1999
    Assignee: Hoechst Marion Roussel
    Inventors: Bertrand Heckmann, Simone Jouquey, Jean-Paul Vevert, Jidong Zhang
  • Patent number: 5977155
    Abstract: Products of formula (1), wherein R.sub.1 is particularly ##STR1## alkyl, alkylthio or alkoxy; R.sub.2 is particularly halogen, --S--R, --O--R or --C(OH)(R)--COOH, where R is alkyl or alkenyl; R.sub.3 is particularly carboxy, acyl, halogen, alkyl, alkenyl or alkylthio; and R.sub.4 is particularly --(CH.sub.2).sub.m1 --COOR.sub.4, --(CH.sub.2).sub.m1 --CONHR.sub.14, --(CH.sub.2).sub.m1 --CN, --SO.sub.2 --NH--SO.sub.2 --R.sub.14, 13 NH--SO.sub.2 --R.sub.14, --PO.sub.3 R.sub.14, or --NH--SO.sub.2 --CF.sub.3, where m1 is 0-4 and R.sub.14 is hydrogen, alkyl or alkenyl; are useful for preparing pharmaceutical compositions for treating disorders resulting from abnormal stimulation of angiotensin II receptors AT.sub.1 and AT.sub.2.
    Type: Grant
    Filed: June 1, 1998
    Date of Patent: November 2, 1999
    Assignee: Hoechst Marion Roussel
    Inventors: Alain Corbier, Pierre Deprez, Michel Fortin, Jacques Guillaume, Bertrand Heckmann
  • Patent number: 5932741
    Abstract: The invention relates to the use and the products of formula (I): ##STR1## in which: R.sub.1 =represents hydroxyl, alkyl, alkenyl, alkynyl, alkoxy, alkylthio, formyl, cycloalkyl, optionally interrupted by heteroatoms,R.sub.2, R.sub.3 represent in particular halogen, mercapto, acyl, carboxy, nitro, cyano, amino, carbamoyl, R.sub.4, --OR.sub.4 with R.sub.4 representing in particular hydrogen, alkyl, alkenyl, alkynyl, acyl, amino, --(CH.sub.2).sub.m1 --S(o).sub.m2 --X--R.sub.10 with m1=0 to 4, m2=0 to 2, X represents a single bond or --NH--, --NH--CO--, --NH--CO--NH--, and R.sub.10 represents alkyl, alkenyl or aryl,and Y represents optionally substituted aryl,these products being in all the isomer forms and the salts, as medicaments.
    Type: Grant
    Filed: June 29, 1998
    Date of Patent: August 3, 1999
    Assignee: Hoechst Marion Roussel
    Inventors: Bertrand Heckmann, Jean-Paul Vevert, Jidong Zhang
  • Patent number: 5856509
    Abstract: The invention relates to the products of formula (I): ##STR1## in which: R.sub.1 =represents hydrogen, aryl, arylcarbonyl, arylthio, alkylcarbonyl,R.sub.2, R.sub.3 represent in particular halogen, mercapto, acyl, carboxy, nitro, cyano, amino, carbamoyl, R.sub.4, --OR.sub.4 with R.sub.4 representing in particular hydrogen, alkyl, alkenyl, alkynyl, acyl, amino, --(CH.sub.2).sub.m1 --S(O).sub.m2 --X--R.sub.10 with m1=0 to 4, m2=0 to 2, X represents a single bond or --NH--, --NH--CO--, --NH--CO--NH--,and R.sub.10 represents alkyl, alkenyl or aryl, and Y represents optionally substituted aryl, these products being in all isomer forms and salts, their use as medicaments.
    Type: Grant
    Filed: January 31, 1997
    Date of Patent: January 5, 1999
    Assignee: Roussel Uclaf
    Inventors: Bertrand Heckmann, Jean-Paul Vevert, Jidong Zhang
  • Patent number: 5811444
    Abstract: The invention relates to the new use and the new products of formula (I): ##STR1## in which: R.sub.1 =represents hydroxyl, alkyl, alkenyl, alkynyl, alkoxy, alkylthio, formyl, cycloalkyl, optionally interrupted by heteroatoms,R.sub.2, R.sub.3 represent in particular halogen, mercapto, acyl, carboxy, nitro, cyano, amino, carbamoyl, R.sub.4, --OR.sub.4 with R.sub.4 representing in particular hydrogen, alkyl, alkenyl, alkynyl, acyl, amino, --(CH.sub.2).sub.m1 --S(O).sub.m2 --X--R.sub.10 with m1=0 to 4, m2=0 to 2, X represents a single bond or --NH--, --NH--CO--, --NH--CO--NH--, and R.sub.10 represents alkyl, alkenyl or aryl, and Y represents optionally substituted aryl, these products being in all the isomer forms and the salts, as medicaments.
    Type: Grant
    Filed: January 31, 1997
    Date of Patent: September 22, 1998
    Assignee: Roussel Uclaf
    Inventors: Bertrand Heckmann, Jean-Paul Vevert, Jidong Zhang
  • Patent number: 5807878
    Abstract: A compound of the formula ##STR1## wherein the substituents are defined in the specification useful for the treatment of cardiovascular disorders.
    Type: Grant
    Filed: August 30, 1996
    Date of Patent: September 15, 1998
    Assignee: Roussel Uclaf
    Inventors: Alain Corbier, Pierre Deprez, Michel Fortin, Jacques Guillaume, Bertrand Heckmann
  • Patent number: 5674883
    Abstract: Products of formula (I): ##STR1## in which: R.sub.1, R.sub.2, R.sub.3 and R.sub.4 represent:--a hydrogen atom, a halogen atom, one of the following radicals: hydroxyl, mercapto, cyano, nitro, sulpho, formyl, benzoyl, acyl, carboxy, cycloalkyl, acyloxy,--an alkyl, alkenyl, alkynyl, alkyloxy or alkythio radical,--an alkyl, alkenyl, alkynyl, alkyloxy or alkylthio radical,--an aryl, arylalkyl, arylalkenyl, aryloxy or arylthio radical,--a radical: ##STR2## --a--(CH.sub.2).sub.m1 --S(O).sub.m2 --Z'--R'.sub.14 radical in which m1 represents an integer from 0 to 4, m2 represents an integer from 0 to 2, R.sub.5 represents a divalent alkylene radical, Y represents the --Y.sub.1 --B--Y.sub.2 radical.These products have useful pharmacological properties, which justify their use as medicaments.
    Type: Grant
    Filed: July 31, 1996
    Date of Patent: October 7, 1997
    Assignee: Roussel Uclaf
    Inventors: Michel Fortin, Jean Luc Haesslein, Bertrand Heckmann