Patents by Inventor Bertrand Merot

Bertrand Merot has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11618769
    Abstract: The present invention relates to methods for purifying heterologous antibodies from caprine milk, such as goat milk. The present invention includes protein A based affinity chromatography to obtain purified transgenically expressed antibodies, in particular concentrates free from endogenous caprine antibodies.
    Type: Grant
    Filed: November 13, 2018
    Date of Patent: April 4, 2023
    Inventors: Régine Freichels, Olivier Favre-Bulle, François Côte, Bertrand Mérot
  • Publication number: 20200283473
    Abstract: The present invention relates to methods for purifying heterologous antibodies from caprine milk, such as goat milk. The present invention includes protein A based affinity chromatography to obtain purified transgenically expressed antibodies, in particular concentrates free from endogenous caprine antibodies.
    Type: Application
    Filed: November 13, 2018
    Publication date: September 10, 2020
    Inventors: Régine Freichels, Olivier Favre-Bulle, François Côte, Bertrand Mérot
  • Patent number: 8334254
    Abstract: The invention concerns the use of a recombinant nucleotide sequence containing a cDNA coding for a lactoferrin, in particular human lactoferrin, or the derived proteins, and elements enabling a plant cell to produce lactoferrin or the derived proteins, coded by the cDNA, in particular a transcription promoter and terminator identified by the plant cell transcription machinery, to transform plant cells in order to obtain, from these cells, or plants obtained therefrom, lactoferrin or derived proteins.
    Type: Grant
    Filed: April 8, 2008
    Date of Patent: December 18, 2012
    Assignee: EDULIS
    Inventors: Dominique Legrand, Valerie Salmon, Genevieve Spik, Veronique Gruber, Philippe Bournat, Bertrand Merot
  • Publication number: 20110092411
    Abstract: The invention concerns the use of a recombinant nucleotide sequence containing a DNAc coding for a lactoferrin, in particular human lactoferrin, or the derived proteins, and elements enabling a plant cell to produce lactoferrin or the derived proteins, coded by said DNAc, in particular a transcription promoter and terminator identified by the plant cell transcription machinery, to transform plant cells in order to obtain, from these cells, or plants obtained therefrom, lactoferrin or derived proteins.
    Type: Application
    Filed: April 8, 2008
    Publication date: April 21, 2011
    Inventors: Dominique Legrand, Valerie Salmon, Genevieve Spik, Veronique Gruber, Philippe Bournat, Bertrand Merot
  • Patent number: 7354902
    Abstract: The invention concerns the use of a recombinant nucleotide sequence containing a cDNA coding for a lactoferrin, in particular human lactoferrin, or the derived proteins, and elements enabling a plant cell to produce lactoferrin or the derived proteins, coded by said cDNA, in particular a transcription promoter and terminator identified by the plant cell transcription machinery, to transform plant cells in order to obtain, from these cells, or plants obtained therefrom, lactoferrin or derived proteins.
    Type: Grant
    Filed: May 27, 2003
    Date of Patent: April 8, 2008
    Assignee: Meristem Therapeutics S.A.
    Inventors: Dominique Legrand, Valerie Salmon, Genevieve Spik, Veronique Gruber, Philippe Bournat, Bertrand Merot
  • Patent number: 6916787
    Abstract: A method for producing haemin proteins by (i) inserting into plant cells one or more nucleic acid molecules that each comprise at least one sequence coding for a protein component of an animal haemin protein capable of reversibly binding oxygen, or for a variant or portion of said protein component, and optionally a sequence coding for a selection agent; (ii) selecting cells containing nucleic acid coding for the protein component of the haemin protein; (iii) optionally propagating the transformed cells either in a culture or by regenerating whole transgenic or chimeric plants; and (iv) recovering and optionally purifying a haemin protein that includes a complex consisting of the protein or proteins coded for by said nucleic acid and at least one iron-containing porphyritic nucleus, or a plurality of such complexes.
    Type: Grant
    Filed: October 18, 2001
    Date of Patent: July 12, 2005
    Assignees: Institut National de la Sante et de Recherche Medicale, Meristern Therapeutics
    Inventors: Bertrand Merot, Wilfrid Dieryck, Philippe Lenee, Michael Marden, Veronique Gruber, Renee-Josee Pagnier, Sylvie Baudino, Claude Poyart
  • Publication number: 20040072317
    Abstract: The invention concerns the use of recombinant nucleotides sequences containing cDNA coding for a preduodenal lipase, or any sequence derived from this cDNA, for transforming plant cells in order to obtain recombinant preduodenal lipase or polypeptide derivatives.
    Type: Application
    Filed: September 17, 2002
    Publication date: April 15, 2004
    Applicant: Meristem Therapeutics
    Inventors: Philippe Lenee, Veronique Gruber, Sylvie Baudino, Bertrand Merot, Claude Benicourt, Claire Cudrey
  • Publication number: 20030229925
    Abstract: The invention concerns the use of a recombinant nucleotide sequence containing a cDNA coding for a lactoferrin, in particular human lactoferrin, or the derived proteins, and elements enabling a plant cell or produce lactoferrin or the derived proteins, coded by said cDNA, in particular a transcription promoter and terminator identified by the plant cell transcription machinery, to transform plant cells in order to obtain, from these cells, or plants obtained therefrom, lactoferrin or derived proteins.
    Type: Application
    Filed: May 27, 2003
    Publication date: December 11, 2003
    Applicant: Meristem Therapeutics S.A.
    Inventors: Dominique Legrand, Valerie Salmon, Genevieve Spik, Veronique Gruber, Philippe Bournat, Bertrand Merot
  • Patent number: 6617431
    Abstract: The invention concerns the use of a recombinant nucleotide sequence containing a cDNA coding for one or several mammalian collagen chains or derived proteins and elements enabling a plant cell to produce the collagen chains(s) or derived proteins, coded by said cDNA, particularly a transcription promoter and terminator identified by the transcription machinery of the plant cells, for transforming the plant cells so as to obtain from these cells, or plants obtained from them, the collagen chain(s) or derived proteins. The invention also concerns the resulting proteins and transformed plant material as well as their uses.
    Type: Grant
    Filed: August 17, 1999
    Date of Patent: September 9, 2003
    Assignee: Meristem Therapeutics S.A.
    Inventors: Veronique Gruber, Jean-Yves Exposito, Florence Ruggiero, Jeanne Comte, Robert Garrone, Bertrand Merot, Philippe Bournat
  • Patent number: 6573431
    Abstract: The invention concerns the use of recombinant nucleotides sequences containing cDNA coding for a preduodenal lipase, or any sequence derived from this cDNA, for transforming plant cells in order to obtain recombinant preduodenal lipase or polypeptide derivatives. The invention also concerns the use of genetically modified plants or parts thereof, or extracts of these plants or the use of recombinant preduodenal lipase or résultant polypeptide derivatives in the field of foodstuffs, or for producing medicaments, or in industry.
    Type: Grant
    Filed: July 2, 1999
    Date of Patent: June 3, 2003
    Assignees: Biochem S.A., Jouveinal S.A.
    Inventors: Philippe Lenee, Véronique Gruber, Sylvie Baudino, Bertrand Merot, Claude Benicourt, Claire Cudrey
  • Patent number: 6569831
    Abstract: The invention concerns the use of a recombinant nucleotide sequence containing a cDNA coding for a lactoferrin, in particular human lactoferrin, or the derived proteins, and elements enabling a plant cell to produce lactoferrin or the derived proteins, coded by the cDNA, in particular a transcription promoter and terminator identified by the plant cell transcription machinery, to transform plant cells in order to obtain, from these cells, or plants obtained therefrom, lactoferrin or derived proteins.
    Type: Grant
    Filed: March 21, 2000
    Date of Patent: May 27, 2003
    Assignee: Meristem Therapeutics S.A.
    Inventors: Dominique Legrand, Valerie Salmon, Genevieve Spik, Veronique Gruber, Philippe Bournat, Bertrand Merot
  • Publication number: 20030096973
    Abstract: The invention concerns the use of a recombinant nucleotide sequence containing a cDNA coding for one or several mammal collagen chains or derived proteins and elements enabling a plant cell to produce the collagen chain(s) or derived proteins, coded by said cDNA, particularly a transcription promoter and terminator identified by the transcription machinery of the plant cells, for transforming the plant cells so as to obtain from these cells, or plants obtained from them, the collagen chain(s) or derived proteins.
    Type: Application
    Filed: August 9, 2002
    Publication date: May 22, 2003
    Applicant: Meristem Therapeutics S.A.
    Inventors: Veronique Gruber, Jean-Yves Exposito, Florence Ruggiero, Jeanne Comte, Robert Garrone, Bertrand Merot, Philippe Bournat
  • Publication number: 20020194643
    Abstract: A method for producing haemin proteins by (i) inserting into plant cells one or more nucleic acid molecules that each comprise at least one sequence coding for a protein component of an animal haemin protein capable of reversibly binding oxygen, or for a variant or portion of said protein component, and optionally a sequence coding for a selection agent; (ii) selecting cells containing nucleic acid coding for the protein component of the haemin protein; (iii) optionally propagating the transformed cells either in a culture or by regenerating whole transgenic or chimeric plants; and (iv) recovering and optionally purifying a haemin protein that includes a complex consisting of the protein or proteins coded for by said nucleic acid and at least one iron-containing porphyritic nucleus, or a plurality of such complexes.
    Type: Application
    Filed: October 18, 2001
    Publication date: December 19, 2002
    Applicant: Meristern Therapeutics and Institut National de la Sante et de la Recherche Medicale
    Inventors: Bertrand Merot, Wilfrid Dieryck, Philippe Lenee, Michael Charles Marden, Veronique Gruber, Renee-Josee Pagnier, Sylvie Baudino, Claude Poyart
  • Patent number: 6344600
    Abstract: A method for producing human hemoglobin proteins by (i) inserting into plant cells one or more nucleic acid molecules that each comprise at least one sequence coding for a protein component of a human hemoglobin protein capable of reversibly binding oxygen, and optionally a sequence coding for a selection agent; (ii) selecting cells containing nucleic acid coding for the protein component of the human hemoglobin protein; (iii) optionally propagating the transformed cells either in a culture or by regenerating whole transgenic or chimeric plants; and (iv) recovering and optionally purifying the human hemoglobin protein that includes a complex consisting of the protein or proteins coded for by the nucleic acid and at least one iron-containing polphyritic nucleus, or a plurality of such complexes.
    Type: Grant
    Filed: June 9, 1998
    Date of Patent: February 5, 2002
    Assignees: Meristem Therapeutics, Institut National de la Sante et de la Recherche Medicale
    Inventors: Bertrand Merot, Wilfrid Dieryck, Philippe Lenee, Michael Marden, Veronique Gruber, Renee-Josee Pagnier, Sylvie Baudino, Claude Poyart