Abstract: Supervised learning is implemented to improve the accuracy of automated diagnoses performed by monitoring units installed at a machine. The monitoring units perform indicator acquisition and automated diagnoses based on a Bayesian model derived in accordance with the machine's known configuration. Raw data is collected, including machine vibration data and other diagnostic data. The data is analyzed to diagnose for specific fault defect assumptions so as to generate the automated diagnoses results and a rating for overall health of the machine. The results are uploaded to an external environment that can be accessed by an expert for review and correction. Based upon the expert's corrections, the Bayesian model is adjusted using supervised learning to improve the automated diagnoses performed by the monitoring units.

Abstract: The invention is based on the discovery of a new bacterial compound with analgesic properties which could be used as a new tool for the treatment of pain disorders such as visceral pain. Studying the mechanisms implicated in analgesic properties of the probiotic Escherichia coli strain Nissle 1917 (EcN), inventors characterized, the amino fatty acids produced by EcN, which display the Ecn analgesic properties. One of these compounds inhibits the hypersensitivity to colorectal distension induced by capsaicin, which is a very powerful nociceptive compound and acts via the GABA B receptor. Furthermore, inventors demonstrate that this compound is able to cross the cellular epithelial barrier (such as the intestinal epithelium). Thus, the invention relates to a lipopetide compound, derived from gamma-aminobutyric acid. The invention also relates to a lipopeptide compound according to the invention for the treatment of treating pain disorder, such as somatic pain and visceral pain.

Abstract: The invention is based on the discovery of a new bacterial compound with analgesic properties which could be used as a new tool for the treatment of pain disorders such as visceral pain. Studying the mechanisms implicated in analgesic properties of the probiotic Escherichia coli strain Nissle 1917 (EcN), inventors characterized, the amino fatty acids produced by EcN, which display the Ecn analgesic properties. One of these compounds inhibits the hypersensitivity to colorectal distension induced by capsaicin, which is a very powerful nociceptive compound and acts via the GABA B receptor. Furthermore, inventors demonstrate that this compound is able to cross the cellular epithelial barrier (such as the intestinal epithelium). Thus, the invention relates to a lipopeptide compound, derived from gamma-aminobutyric acid. The invention also relates to a lipopeptide compound according to the invention for the treatment of treating pain disorder, such as somatic pain and visceral pain.

Abstract: The invention is based on the discovery of a new bacterial compound with analgesic properties which could be used as a new tool for the treatment of pain disorders such as visceral pain. Studying the mechanisms implicated in analgesic properties of the probiotic Escherichia coli strain Nissle 1917 (EcN), inventors characterized, the amino fatty acids produced by EcN, which display the Ecn analgesic properties. One of these compounds inhibits the hypersensitivity to colorectal distension induced by capsaicin, which is a very powerful nociceptive compound and acts via the GABA B receptor. Furthermore, inventors demonstrate that this compound is able to cross the cellular epithelial barrier (such as the intestinal epithelium). Thus, the invention relates to a lipopetide compound, derived from gamma-aminobutyric acid. The invention also relates to a lipopeptide compound according to the invention for the treatment of treating pain disorder, such as somatic pain and visceral pain.

Abstract: A system and method for consistent and highly accurate blending of fluids; e.g. gases or liquids, without significant pressure drop. The system uses a flow meter to measure the amount of primary fluid being provided for mixing with the amount of diluent fluid controlled based on such measurement of the primary fluid amount.

Abstract: A foam control composition comprises a polydiorganosiloxane fluid comprising units of the formula where each group R, which may be the same or different, is selected from an alkyl group having 1 to 36 carbon atoms or an aryl group or aralkyl group having up to 36 carbon atoms, the mean number of carbon atoms in the groups R being at least 1.3, and an additive composition having a melting point of at least 35° C. comprising 5-50 parts by weight of a non-polar component (A) and 50-95 parts by weight of a component (B) which is miscible with component (A) and is more polar than component (A), at least one of (A) and (B) being miscible with the polysiloxane fluid.

Abstract: A foam control composition comprises a polydiorganosiloxane fluid comprising units of the formula where each group R, which may be the same or different, is selected from an alkyl group having 1 to 36 carbon atoms or an aryl group or aralkyl group having up to 36 carbon atoms, the mean number of carbon atoms in the groups R being at least 1.3, and an additive composition having a melting point of at least 35° C. comprising 5-50 parts by weight of a non-polar component (A) and 50-95 parts by weight of a component (B) which is miscible with component (A) and is more polar than component (A), at least one of (A) and (B) being miscible with the polysiloxane fluid.

Abstract: An emulsion for controlled fragrance release comprises a disperse phase which is a blend of a fragrance composition and a waxy hydrophobic material having a melting point in the range 10-200° C. dispersed in a continuous phase comprising an aqueous solution of concentration at least 0.1 molar of a salt capable of ionic disassociation in water.

Abstract: A mixer blade which is adapted to be mounted on the shaft of a vertical continuous granulating mixer, characterised in that an inner portion of the leading edge of the blade is bevelled upwards and an outer portion of the leading edge of the blade is substantially vertical or is bevelled downwards. A vertical continuous granulating mixer which comprises a shaft fitted with blades rotating within a tubular housing and having an inlet for solid particles and a spray inlet for liquid to contact the solid particles above the blades, characterised in that an inner portion of at least one of the blades is angled forwards and upwards over at least part of its area so that particles hitting the angled portion of the blade acquire an upwards velocity component.

Abstract: In an agglomeration process for the preparation of granules encapsulating a hydrophobic active material, the active material and a molten binder which has a melting point above ambient temperature are sprayed onto water soluble carrier particles while agitating the particles. A liquid which interacts exothermically with the carrier particles is sprayed onto the carrier particles separately from and just before or simultaneously with the active material and binder, so that the heat generated by the interaction reduces the cooling rate of the binder during the agglomeration process. For example the liquid can be water when the carrier particles have a positive heat of hydration and/or solution by water.

Abstract: Structural elements such as X-type or V-type support posts for structures such as cooling towers are each prefabricated on the ground in the position which would be occupied on the theoretical assumption that, after erection, the post had been lowered to the ground in a movement of pivotal displacement about its foot. An articulated coupling is interposed between the foot of the post and the foundation footing of the structure. On completion of the prefabrication process, the post is lifted at one end by means of a hoisting machine and moved upwards in pivotal motion about the pivot-pin of the articulated coupling. After reaching its final position, the foot of the post is embedded in a concrete block cast on the foundation footing.