Patents by Inventor Bertrand Tavitian
Bertrand Tavitian has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11940578Abstract: An imaging method including: a) acquiring N successive positron emission tomography (PET) low resolution images ?i and simultaneously, N successive Ultrafast Ultrasound Imaging (UUI) images Ui of a moving object; b) determining from each UUI image Ui, the motion vector fields Mi that corresponds to the spatio-temporal geometrical transformation of the motion of the object; c) obtaining a final estimated high resolution image H of the object by iterative determination of a high resolution image Hn+1 obtained by applying several correction iterations to a current estimated high resolution image Hn, n being the number of iterations, starting from an initial estimated high resolution image H1 of the object, each correction iteration including at least: i) warping the estimated high resolution image Hn using the motion vector fields Mi to determine a set of low resolution reference images Lni; ii) determining a differential image Di by difference between each PET image ?i and the corresponding low resolution reType: GrantFiled: January 28, 2021Date of Patent: March 26, 2024Assignees: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE), UNIVERSITÉ DE PARIS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS, ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARISInventors: Bertrand Tavitian, Mickaël Tanter, Mailyn Perez-Liva, Joaquin Lopez Herraiz, Jean Provost
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Publication number: 20230309944Abstract: The invention relates to a method for determining at least one property of an object, the method comprising a step of: a) obtaining first data relative to the object by an ultrasound imaging technique imaging the object at a frame rate superior to 300 Hz, characterized in that the method further comprises a step of: b) obtaining second data relative to the object by imaging the object with at least one of a X-ray and a ?-ray, and c) determining the at least one property of the object based on the first data and the second data.Type: ApplicationFiled: June 7, 2023Publication date: October 5, 2023Inventors: Jean PROVOST, Anikitos GAROFALAKIS, Mathieu PERNOT, Mickaël TANTER, Bertrand TAVITIAN, Thomas VIEL
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Publication number: 20210239863Abstract: An imaging method including: a) acquiring N successive positron emission tomography (PET) low resolution images ?i and simultaneously, N successive Ultrafast Ultrasound Imaging (UUI) images Ui of a moving object; b) determining from each UUI image Ui, the motion vector fields Mi that corresponds to the spatio-temporal geometrical transformation of the motion of the object; c) obtaining a final estimated high resolution image H of the object by iterative determination of a high resolution image Hn+1 obtained by applying several correction iterations to a current estimated high resolution image Hn, n being the number of iterations, starting from an initial estimated high resolution image H1 of the object, each correction iteration including at least: i) warping the estimated high resolution image Hn using the motion vector fields Mi to determine a set of low resolution reference images Lni; ii) determining a differential image Di by difference between each PET image ?i and the corresponding low resolution reType: ApplicationFiled: January 28, 2021Publication date: August 5, 2021Inventors: Bertrand TAVITIAN, Mickaël TANTER, Mailyn PEREZ-LIVA, Joaquin LOPEZ HERRAIZ, Jean PROVOST
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Publication number: 20180271471Abstract: The invention relates to a method for determining at least one property of an object, the method comprising a step of: a) obtaining first data relative to the object by an ultrasound imaging technique imaging the object at a frame rate superior to 300 Hz, characterized in that the method further comprises a step of: b) obtaining second data relative to the object by imaging the object with at least one of a X-ray and a ?-ray, and c) determining the at least one property of the object based on the first data and the second data.Type: ApplicationFiled: September 29, 2016Publication date: September 27, 2018Inventors: Jean PROVOST, Anikitos GAROFALAKIS, Mathieu PERNOT, Mickaël TANTER, Bertrand TAVITIAN, Thomas VIEL
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Patent number: 9839700Abstract: The invention relates to polymerized micelles of size inferior to 100 nm for in vivo diagnosis, in particular of cancer. The polymerized micelles of the invention comprise a diagnostic agent and an amphiphilic polymer obtainable by the polymerization of an amphiphilic monomer, said monomer comprising: a lipophilic chain comprising a polymerizable vinylic or diacetylenic group, and a hydrophilic head comprising a polyoxyethylene or polyoxypropylene chain. The invention finds application in the pharmaceutical field, in particular.Type: GrantFiled: July 7, 2011Date of Patent: December 12, 2017Assignee: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVESInventors: Eric Doris, Frédéric Duconge, Edmond Gravel, Nicolas Mackiewicz, Bertrand Tavitian
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Patent number: 9707305Abstract: The present invention relates to a formulation of a therapeutic or diagnostic agent in the form of a nano-emulsion, to its preparation method and to the use of this formulation for treating or diagnosing hormone-dependent cancers or cancers of organs synthesizing steroidal hormones.Type: GrantFiled: September 26, 2012Date of Patent: July 18, 2017Assignee: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVESInventors: Juliette Merian, Raphaël Boisgard, Bertrand Tavitian, Isabelle Texier-Nogues
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Publication number: 20170160287Abstract: Use of a radiolabelled form of 7-chloro-?/?,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4/?/?pyridazino[4,5-b]indole-1-acetamide as a biomarker for the detection, in an individual, of PBR levels associated with normal and pathological conditions. Method for the detection of PBR levels associated with normal and pathological conditions. Diagnostic kit.Type: ApplicationFiled: November 10, 2016Publication date: June 8, 2017Inventors: Jesus BENAVIDES, Hérve BOUTIN, Marie-Noëlle CASTEL, Annelaure DAMONT, Frédéric DOLLE, Philippe HANTRAYE, Frank MARGUET, Thomas ROONEY, Luc RIVRON, Bertrand TAVITIAN, Cyrille THOMINIAUX
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Patent number: 9125937Abstract: The present invention relates to the compound of formula (I): in which R1 represents a hydrogen atom, an optionally labelled halogen, a radionuclide or a Sn[(C1-C4)alkyl]3 group, Ar represents an aryl group or a heteroaryl group, R9 represents a hydrogen atom, a (C1-C4)alkyl group or forms together with the group R1—Ar a ring fused with the Ar group, A represents a group of formula (?) or (?): R3 and R4 independently represent a hydrogen atom, a (C1-C6)alkyl group, a (C1-C6)alkenyl group or a group of formula (?): —Y—Z—W—R11??(?) wherein R11 represents an optionally labelled halogen, a radionuclide, an aryl or heteroaryl group optionally substituted by an optionally labelled halogen, a radionuclide, a —NO2 group, a —NR5R6 group, a —N+R5R6R7X? group, or a —OSO2R12 group, and their addition salts with pharmaceutically acceptable acids.Type: GrantFiled: September 19, 2013Date of Patent: September 8, 2015Assignees: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, UNIVERSITE D'AUVERGNE CLERMONT 1, LABORATORIES CYCLOPHARMAInventors: Jean-Michel Chezal, Frederic Dolle, Jean-Claude Madelmont, Aurelie Maisonial, Elisabeth Miot-Noirault, Nicole Moins, Janine Papon, Bertrand Kuhnast, Bertrand Tavitian, Raphael Boisgard
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Publication number: 20150030543Abstract: The present invention relates to a formulation of a therapeutic or diagnostic agent in the form of a nano-emulsion, to its preparation method and to the use of this formulation for treating or diagnosing hormone-dependent cancers or cancers of organs synthesizing steroidal hormones.Type: ApplicationFiled: September 26, 2012Publication date: January 29, 2015Applicant: Commissariat à l'énergie atomique et aux énergies alternativesInventors: Juliette Merian, Raphaël Boisgard, Bertrand Tavitian, Isabelle Texier-Nogues
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Publication number: 20140093453Abstract: The present invention relates to the compound of formula (I): in which R1 represents a hydrogen atom, an optionally labelled halogen, a radionuclide or a Sn[(C1-C4)alkyl]3 group, Ar represents an aryl group or a heteroaryl group, R9 represents a hydrogen atom, a (C1-C4)alkyl group or forms together with the group R1—Ar a ring fused with the Ar group, A represents a group of formula (?) or (?): R3 and R4 independently represent a hydrogen atom, a (C1-C6)alkyl group, a (C1-C6)alkenyl group or a group of formula (?): —Y—Z—W—R11??(?) wherein R11 represents an optionally labelled halogen, a radionuclide, an aryl or heteroaryl group optionally substituted by an optionally labelled halogen, a radionuclide, a —NO2 group, a —NR5R6 group, a —N+R5R6R7X? group, or a —OSO2R12 group, and their addition salts with pharmaceutically acceptable acids.Type: ApplicationFiled: September 19, 2013Publication date: April 3, 2014Applicants: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), LABORATOIRES CYCLOPHARMA, UNIVERSITE D'AUVERGNE CLERMONT 1, COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVESInventors: Jean-Michel CHEZAL, Frederic DOLLE, Jean-Claude MADELMONT, Aurelie MAISONIAL, Elisabeth MIOT-NOIRAULT, Nicole MOINS, Janine PAPON, Bertrand KUHNAST, Bertrand TAVITIAN, Raphael BOISGARD
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Patent number: 8615117Abstract: A method provides for estimating the concentration of a tracer in a tissue structure assembly including at least one tissue structure, from a measurement image of the tracer concentration in said tissue structure assembly, which is obtained by an imaging apparatus, wherein said image includes at least one space domain inside which the tracer concentration is homogenous and at least one region of interest in which the tracer concentration is measured.Type: GrantFiled: September 18, 2009Date of Patent: December 24, 2013Assignee: Commissariat a l'Energie Atomique et aux Energies AlternativesInventors: Renaud Maroy, Bertrand Tavitian
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Publication number: 20130261096Abstract: The present invention relates to a formulation as a nanoemulsion, comprising a continuous aqueous phase and at least one dispersed phase, and comprising: an amphiphilic lipid, a solubilizing lipid, a hormone, a hormone agonist or antagonist or a mixture thereof, and a co-surfactant comprising at least one chain consisting of alkylene oxide units for its use for hormonal treatment selected from contraception, reproduction assistance, post-menopausal hormonal treatment, treatment of menorrhagias, treatment of acne and treatment of adrenal dysregulations.Type: ApplicationFiled: March 29, 2013Publication date: October 3, 2013Inventors: Juliette MERIAN, Raphaël BOISGARD, Bertrand TAVITIAN, Isabelle TEXIER-NOGUES
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Publication number: 20130230467Abstract: The invention relates to polymerized micelles of size inferior to 100 nm for in vivo diagnosis, in particular of cancer. The polymerized micelles of the invention comprise a diagnostic agent and an amphiphilic polymer obtainable by the polymerization of an amphiphilic monomer, said monomer comprising: a lipophilic chain comprising a polymerizable vinylic or diacetylenic group, and a hydrophilic head comprising a polyoxyethylene or polyoxypropylene chain. The invention finds application in the pharmaceutical field, in particular.Type: ApplicationFiled: July 7, 2011Publication date: September 5, 2013Applicant: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVESInventors: Eric Doris, Frédéric Duconge, Edmond Gravel, Nicolas MacKiewicz, Bertrand Tavitian
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Publication number: 20120039816Abstract: Use of a radiolabelled form of 7-chloro-?/,?/,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4/-/-pyridazino[4,5-b]indole-1-acetamide as a biomarker for the detection, in an individual, of PBR levels associated with normal and pathological conditions. Method for the detection of PBR levels associated with normal and pathological conditions. Diagnostic kit.Type: ApplicationFiled: October 27, 2009Publication date: February 16, 2012Applicants: SANOFI-AVENTIS, COMMISSARIAT A L'ENERGIE ATOMIQUEInventors: Jesus Benavides, Hérve Boutin, Marie-Noëlle Castel, Annelaure Damont, Frédéric Dolle, Philippe Hantraye, Frank Marguet, Thomas Rooney, Luc Rivron, Bertrand Tavitian, Cyrille Thominiaux
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Publication number: 20110317889Abstract: A method provides for estimating the concentration of a tracer in a tissue structure assembly including at least one tissue structure, from a measurement image of the tracer concentration in said tissue structure assembly, which is obtained by an imaging apparatus, wherein said image includes at least one space domain inside which the tracer concentration is homogenous and at least one region of interest in which the tracer concentration is measured.Type: ApplicationFiled: September 18, 2009Publication date: December 29, 2011Inventors: Renaud Maroy, Bertrand Tavitian
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Publication number: 20110044899Abstract: A compound of formula (I): in which R1 represents a hydrogen atom, an optionally labelled halogen, a radionuclide or a Sn[(C1-C4)alkyl]3 group, Ar represents an aryl group or a heteroaryl group, R9 represents a hydrogen atom, a (C1-C4) alkyl group or forms together with the group R1—Ar a ring fused with the Ar group, A represents a group of formula (?) or (?): R3 and R4 independently represent a hydrogen atom, a (C1-C6)alkyl group, a (C1-C6) alkenyl group or a group of formula (y): wherein R11 represents an optionally labelled halogen, a radionuclide, an aryl or heteroaryl group optionally substituted by an optionally labelled halogen, a radionuclide, a —NO2 group, a —NR5R6 group, a N+R5R6R7X? group, or a —OSO2R12 group, and their addition salts with pharmaceutically acceptable acids.Type: ApplicationFiled: January 28, 2009Publication date: February 24, 2011Applicants: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, UNIVERSITE D'AUVERGNE CLERMONT 1, LABORATOIRES CYCLOPHARMAInventors: Jean-Michel Chezal, Frederic Dolle, Jean-Claude Madelmont, Aurelie Maisonial, Elisabeth Miot-Noirault, Nicole Moins, Janine Papon, Bertrand Kuhnast, Bertrand Tavitian, Raphael Boisgard
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Method of segmentation of a sequence of three-dimensional images, in particular in pharmaco-imagerie
Patent number: 7630550Abstract: The present invention relates to a method of segmenting a starting image or sequence of tridimensional images for obtaining a tridimensional segmentation image comprising a partition into regions of interest, said image or sequence of images comprising measurements, for each voxel and in the course of n time intervals (n?1), of the real evolution of a signal representative of at least one variable of said image or sequence, which comprises essentially: a) a modeling (10) of the signal comprising the definition of a parametric model of spatio-temporal evolution of said signal, this model comprising sets of homogeneous parameters respectively specific to structures corresponding to said regions of interest; b) an extraction (30) of samples of voxels respectively included in said structures; then c) a merging (50b) of the samples grouping together those whose evolution model is specific to the same structure, said merging following, preceding or including a classification of all the voxels of said image or seType: GrantFiled: January 20, 2006Date of Patent: December 8, 2009Assignee: Commissariat a l'Energie AtomiqueInventors: Renaud Maroy, Bertrand Tavitian, Vincent Frouin -
Patent number: 7541157Abstract: The invention relates to an amplification-free method of screening groups of radioactive molecules, comprising at least the following steps: (1) the group of molecules is administered to at least one animal; (2) at least one of the animals is slaughtered and the tissue distribution of the radioactivity of the molecules administered is analyzed in vivo; (3) sections of tissue or organs in which a radioactivity signal is detected are selected; (4) radioactive fractions from the sections of tissue or organs are isolated using suitable techniques such as chromatography and/or extraction techniques; and (5) the molecule(s) from the radioactive fractions obtained in step 4 are characterized using suitable analysis techniques such as chromatography and/or mass spectrometry.Type: GrantFiled: May 28, 2003Date of Patent: June 2, 2009Assignee: Commissariat a l'Energie AtomiqueInventors: Vincent Dive, André Menez, Reto Stocklin, Bertrand Tavitian, Fabrice Beau, Bertrand Czarny, Joël Cotton
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Publication number: 20080227735Abstract: The invention relates to aptamers selected from live tumor cells and to the use thereof for diagnosis and treatment of certain cancers and other pathologies.Type: ApplicationFiled: March 17, 2005Publication date: September 18, 2008Applicant: COMMISSARIAT A L'ENERGIE ATOMIQUEInventors: Bertrand Tavitian, Frederic Duconge, Domenico Libri, Vittorio De Franciscis, Laura Cerchia
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Publication number: 20070080305Abstract: The luminescence imaging apparatus comprises: a stage receiving a sample (2) emitting luminescence information about the sample; a light source (8) illuminating the stage; and an electronic control unit defining time frames; a combined light signal corresponding to a combination of luminescence information and of the reflection on the sample of the illumination. During each time frame, the detection apparatus (9) acquires both first data relating to the luminescence information, and also second data relating to the second light signal.Type: ApplicationFiled: November 21, 2005Publication date: April 12, 2007Applicant: BIOSPACE MESURESInventors: Serge Maitrejean, Pascal Asselin, Emilie Roncali, Bertrand Tavitian