Abstract: An anionic bi-coordinated silver (I) complex has antimicrobial activity and the general formula [Ag+(L2?)2]3?, wherein L2? is a ligand selected from the group consisting of 2-mercapto-4-methyl-5-thiazole acetate, 3-mercapto-1-propansulfonate, 2-mercapto-5-benzimidazole sulfonate and thiosalicylate. A sodium salt of the aforesaid anionic bi-coordinated silver (I) complex has antimicrobial activity and the general formula Na+3[Ag+(L2?)2]3?. A salt of the aforesaid anionic bi-coordinated silver (I) complex has antimicrobial activity and the general formula (W+)3[Ag+(L2?)2]n, wherein W+ is a cationic surface-active agent, selected from the group consisting of octenidine, chlorhexidine, benzalkonium and didecyldimethylammonium; n is 2 when W+ is octenidine or chlorhexidine; n is 1 when W+ is benzalkonium or didecyldimethylammonium. The anionic bi-coordinated silver (I) complex can be incorporated in an antimicrobial gel containing sodium hyaluronate and sodium ascorbyl phosphate.

Abstract: A composition, usable for removing a biofilm and necrotic or infected tissues from a skin lesion, comprises ethanesulfonic acid or 1-propanesulfonic acid and a proton acceptor. The proton acceptor is selected from the group consisting of: dimethyl sulfoxide, silicon dioxide, tetraethoxysilane, and mixtures thereof. The aforesaid composition can be prepared in the form of a gel.