Patents by Inventor Bertus Pieter Koekman

Bertus Pieter Koekman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Fermentative production of valuable compounds on an industrial scale using chemically defined media
    Publication number: 20020039758
    Abstract: The present invention describes the use of chemically defined media for the fermentative production of valuable compounds on an industrial scale. Microbial strains which are suitable for fermentation on an industrial scale using a chemically defined medium include fungal, yeast and bacterial strains. Suitable strains can be obtained as wild type strains or by screening and selection after mutagenic treatment or DNA transformation.
    Type: Application
    Filed: October 17, 2001
    Publication date: April 4, 2002
    Inventors: Wilhelmus Theodorus Antonius Maria De Laat, Johannes Cornelis Gerardus Preusting, Bertus Pieter Koekman
  • Process for the production of 7-ADCA via expandase activity on penicillin G
    Patent number: 6020151
    Abstract: A process is taught for the preparation and recovery of 7-aminodesacetoxycephalosporanic acid (7-ADCA) via enzymatic ring expansion activity on penicillin G, using a Penicillium chrysogenum transformant strain expressing expandase.
    Type: Grant
    Filed: February 18, 1998
    Date of Patent: February 1, 2000
    Assignee: DSM N.V.
    Inventors: Roelof Ary Lans Bovenberg, Bertus Pieter Koekman, Dirk Schipper, Adrianus Wilhelmus Hermanus Vollebregt
  • Process for the efficient production of 7-ADCA via 3-(carboxyethylthio) propionyl-7-ADCA
    Patent number: 5795733
    Abstract: An overall efficient process for the preparation and recovery of 7-aminodesacetoxycephalosporanic acid (7-ADCA) via 3-(carboxyethylthio)propionyl-7-ADCA, using a Penicillium chrysogenum transformant strain expressing expandase in conjunction with acyltransferase, is provided.
    Type: Grant
    Filed: May 13, 1996
    Date of Patent: August 18, 1998
    Assignee: Gist-Brocades, B.V.
    Inventors: Roelof Ary Lans Bovenberg, Bertus Pieter Koekman, Andreas Hoekema, Jan Metske Van Der Laan, Jan Verweij, Erik De Vroom
  • Process for the production of 7-ADCA via expandase activity on penicillin G
    Patent number: 5731165
    Abstract: An overall process for the preparation and recovery of 7-aminodesacetoxycephalosporanic acid (7-ADCA) via enzymatic ring expansion activity on penicillin G, using a Penicillium chrysogenum transformant strain expressing expandase.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: March 24, 1998
    Assignee: Gist-brocades, B.V.
    Inventors: Roelof Ary Lans Bovenberg, Bertus Pieter Koekman, Dirk Schipper, Adrianus Wilhelmus Vollebregt
  • Process for the efficient production of 7-ADCA via 2-(carboxyethylthio)acetyl-7-ADCA and 3-(carboxymethylthio)propionyl-7-ADCA
    Patent number: 5726032
    Abstract: An overall efficient process for the preparation and recovery of 7-aminodesacetoxycephalosporanic acid (7-ADCA) via 2-(carboxyethylthio)acetyl- and 3-(carboxymethylthio)propionyl-7-ADCA, using a Penicillium chrysogenum transformant strain expressing expandase in conjunction with acyltransferase, is provided.
    Type: Grant
    Filed: April 4, 1996
    Date of Patent: March 10, 1998
    Assignee: Gist-Brocades B.V.
    Inventors: Roelof Ary Lans Bovenberg, Bertus Pieter Koekman, Andreas Hoekema, Jan Metske Van Der Laan, Jan Verweij, Erik De Vroom
  • Intersexual heterozygous phycomyces
    Patent number: 5643719
    Abstract: The present invention discloses intersexual heterozygous Phycomyces strains. These strains show an improved .beta.-carotene productivity and an increased stability when compared with both the wild type and heterokaryotic Phycomyces strains. The present invention also discloses a method for obtaining Phycomyces transformants without using selection markers. Furthermore, a process is provided for manufacturing .beta.-carotene comprising the use of intersexual heterozygous Phycomyces strains in a submerged culture.
    Type: Grant
    Filed: February 2, 1994
    Date of Patent: July 1, 1997
    Assignee: Gist-brocades, N.V.
    Inventors: Enrique Cerda-Olmedo, Bina Jamnadas Mehta, Petrus Wilhelmus Maria Van Dijck, Bertus Pieter Koekman