Patents by Inventor Besim Ogretmen

Besim Ogretmen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SPHINGOLIPID-BASED SELENIUM COMPOUNDS, METHODS FOR THEIR PREPARATION, AND PHARMACEUTICAL USES THEREOF, INCLUDING AS ANTITUMOR AGENTS
    Publication number: 20220288109
    Abstract: Ionic conjugates of selenite anions and cationic ceramide analogs are described. For instance, conjugates can comprise ionic conjugates of selenite anions and pyridinium-substituted ceramide analogs. Also described is the use of the ionic conjugates in treating cancer, such as head and neck cancer and brain cancer.
    Type: Application
    Filed: August 28, 2020
    Publication date: September 15, 2022
    Inventors: Zdzislaw M. SZULC, Besim OGRETMEN, Natalia OLEINIK
  • POLYPEPTIDES FOR IMPROVED RESPONSE TO ANTI-CANCER THERAPY
    Publication number: 20190255146
    Abstract: The present disclosure provides E2F5 mimetic polypeptides. Further provided are methods for the treatment of cancer, such as head and neck cancer, comprising administering the E2F5 mimetic polypeptides alone or in combination with an additional anti-cancer therapy, such as a chemotherapeutic.
    Type: Application
    Filed: October 30, 2017
    Publication date: August 22, 2019
    Applicant: MUSC FOUNDATION FOR RESEARCH DEVELOPMENT
    Inventors: Besim OGRETMEN, Raquela J. THOMAS, Natalia OLEINIK
  • Cationic ceramides, and analogs thereof, and their use for preventing or treating cancer
    Patent number: 8093393
    Abstract: The present invention relates to cationic ceramides, their dihydro-analogs and aromatic analogs and their derivatives, comprising a pyridinium group. Also provided are methods for making cationic ceramides comprising a pyridinium group, and their use for treating or preventing diseases associated with cell overproliferation and sphingolipid signal transduction, such as cancer, inflammation, and stenosis. The compounds are also useful as mitochondritropic agents that are localized to mitochondria carrying with them chemical cargoes, such as drugs, or signaling molecules, such as fluorophores for probing organelle structure and functions.
    Type: Grant
    Filed: October 31, 2005
    Date of Patent: January 10, 2012
    Assignee: MUSC Foundation for Research Development
    Inventors: Alicja Bielawska, Zdzislaw M. Szulc, Yusuf A. Hannun, Lina M. Obeid, Besim Ogretmen
  • Cationic Ceramides, And Analogs Thereof, And Their Use For Preventing Or Treating Cancer
    Publication number: 20110071099
    Abstract: The present invention relates to cationic ceramides, their dihydro-analogs and aromatic analogs and their derivatives, comprising a pyridinium group. Also provided are methods for making cationic ceramides comprising a pyridinium group, and their use for treating or preventing diseases associated with cell overproliferation and sphingolipid signal transduction, such as cancer, inflammation, and stenosis. The compounds are also useful as mitochondritropic agents that are localized to mitochondria carrying with them chemical cargoes, such as drugs, or signaling molecules, such as fluorophores for probing organelle structure and functions.
    Type: Application
    Filed: October 31, 2005
    Publication date: March 24, 2011
    Inventors: Alicja Bielawska, Zdzislaw M. Szuic, Yusuf A. Hannun, Lina M. Obeid, Besim Ogretmen