Patents by Inventor Beth Apsel

Beth Apsel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • KINASE ANTAGONISTS
    Publication number: 20230111917
    Abstract: The present invention provides novel compounds that are antagonists of PI3 kinase, PI3 kinase and tyrosine kinase, PI3 kinase and mTOR, or PI33 kinase, mTOR and tyrosine kinase.
    Type: Application
    Filed: March 31, 2022
    Publication date: April 13, 2023
    Inventors: Zachary A. Knight, Beth Apsel, Kevan M. Shokat
  • MTOR modulators and uses thereof
    Patent number: 9629843
    Abstract: The present invention provides methods and compositions for selective modulation of certain protein kinases, and especially mTor complexes. The methods and compositions are particularly useful in inhibiting mTor selectively for therapeutic applications.
    Type: Grant
    Filed: June 5, 2015
    Date of Patent: April 25, 2017
    Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, INTELLIKINE, INC.
    Inventors: Kevan M. Shokat, David Fruman, Pingda Ren, Troy Edward Wilson, Liansheng Li, Andrew Hsieh, Morris Feldman, Beth Apsel, Yi Liu, Christian Rommel, Katrina Chan, Davide Ruggero, David Pearce, Matthew Janes
  • MTOR MODULATORS AND USES THEREOF
    Publication number: 20160000789
    Abstract: The present invention provides methods and compositions for selective modulation of certain protein kinases, and especially mTor complexes. The methods and compositions are particularly useful in inhibiting mTor selectively for therapeutic applications.
    Type: Application
    Filed: June 5, 2015
    Publication date: January 7, 2016
    Inventors: Kevan M. Shokat, David Fruman, Pingda Ren, Troy Edward Wilson, Liansheng Li, Andrew Hsieh, Morris Feldman, Beth Apsel, Yi Liu, Christian Rommel, Katrina Chan, Davide Ruggero, David Pearce, Matthew Janes
  • Substituted pyrazolo[3,2-d]pyrimidines as anti-cancer agents
    Patent number: 8642604
    Abstract: The present invention provides novel compounds that are antagonists of PI3 kinase, PI3 kinase and tyrosine kinase, PI3 kinase and mTOR, or PI33 kinase, mTOR and tyrosine kinase.
    Type: Grant
    Filed: July 24, 2009
    Date of Patent: February 4, 2014
    Assignee: The Regents of the University of California
    Inventors: Zachary A. Knight, Beth Apsel, Kevan M. Shokat
  • Kinase Antagonists
    Publication number: 20110301144
    Abstract: The present invention provides novel compounds that are antagonists of PI3 kinase, PI3 kinase and tyrosine kinase, PI3 kinase and mTOR, or PI33 kinase, mTOR and tyrosine kinase.
    Type: Application
    Filed: January 29, 2011
    Publication date: December 8, 2011
    Applicant: The Regents of the University of California
    Inventors: Zachary A. Knight, Beth Apsel, Kevan M. Shokat
  • MTOR Modulators and Uses Thereof
    Publication number: 20110224223
    Abstract: The present invention provides methods and compositions for selective modulation of certain protein kinases, and especially mTor complexes. The methods and compositions are particularly useful in inhibiting mTor selectively for therapeutic applications.
    Type: Application
    Filed: July 8, 2009
    Publication date: September 15, 2011
    Applicants: The Regents of the University of California, a California corporation, Intellikine, Inc.
    Inventors: Kevan M. Shokat, David Fruman, Pingda Ren, Troy Edward Wilson, Liansheng Li, Andrew Hsieh, Morris Feldman, Beth Apsel, Yi Liu, Christian Rommel, Katrina Chan, Davide Ruggero, David Pearce, Matthew Janes
  • KINASE ANTAGONISTS
    Publication number: 20100009963
    Abstract: The present invention provides novel compounds that are antagonists of PI3 kinase, PI3 kinase and tyrosine kinase, PI3 kinase and mTOR, or PI33 kinase, mTOR and tyrosine kinase.
    Type: Application
    Filed: July 24, 2009
    Publication date: January 14, 2010
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: ZACHARY A. KNIGHT, BETH APSEL, KEVAN M. SHOKAT
  • Substituted pyrazolo[3,4-D]pyrimidines as kinase antagonists
    Patent number: 7585868
    Abstract: The present invention provides novel compounds that can be used as antagonists of a lipid kinase such as a PI3 kinase, protein tyrosine kinase, and/or protein serine-threonine kinases such as mTOR. The present invention also provides methods of using the compounds for treating various disease conditions. The compounds include those having the formula: wherein the R1, R2 and R36 are as defined herein.
    Type: Grant
    Filed: April 4, 2007
    Date of Patent: September 8, 2009
    Assignee: The Regents of the University of California
    Inventors: Zachary A. Knight, Beth Apsel, Kevan M. Shokat
  • Kinase antagonists
    Publication number: 20070293516
    Abstract: The present invention provides novel compounds that are antagonists of PI3 kinase, PI3 kinase and tryosine kinase, PI3Kinase and mTOR, or PI3Kinase, mTOR and tryosine kinase.
    Type: Application
    Filed: April 4, 2007
    Publication date: December 20, 2007
    Applicant: Regents of the University of California
    Inventors: Zachary Knight, Beth Apsel, Kevan Shokat