Patents by Inventor Beth E. Borowsky

Beth E. Borowsky has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7517658
    Abstract: This invention provides isolated nucleic acids encoding mammalian SNORF33 receptors, purified mammalian SNORF33 receptors, vectors comprising nucleic acid encoding mammalian SNORF33 receptors, cells comprising such vectors, antibodies directed to mammalian SNORF33 receptors, nucleic acid probes useful for detecting nucleic acid encoding mammalian SNORF33 receptors, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding mammalian SNORF33 receptors, transgenic, nonhuman animals which express DNA encoding normal or mutant mammalian SNORF33 receptors, methods of isolating mammalian SNORF33 receptors, methods of treating an abnormality that is linked to the activity of the mammalian SNORF33 receptors, as well as methods of determining binding of compounds to mammalian SNORF33 receptors, methods of identifying agonists and antagonists of SNORF33 receptors, and agonists and antagonists so identified.
    Type: Grant
    Filed: September 15, 2005
    Date of Patent: April 14, 2009
    Assignee: H. Lundbeck A/S
    Inventors: Beth E. Borowsky, Kristine L. Ogozalek, Kenneth A. Jones
  • Patent number: 7416848
    Abstract: This invention provides isolated nucleic acids encoding mammalian SNORF25 receptors, purified mammalian SNORF25 receptors, vectors comprising nucleic acid encoding mammalian SNORF25 receptors, cells comprising such vectors, antibodies directed to mammalian SNORF25 receptors, nucleic acid probes useful for detecting nucleic acid encoding mammalian SNORF25 receptors, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding mammalian SNORF25 receptors, transgenic, nonhuman animals which express DNA encoding normal or mutant mammalian SNORF25 receptors, methods of isolating mammalian SNORF25 receptors, methods of treating an abnormality that is linked to the activity of the mammalian SNORF25 receptors, as well as methods of determining binding of compounds to mammalian SNORF25 receptors, methods of identifying agonists and antagonists of SNORF25 receptors, and agonists and antagonists so identified.
    Type: Grant
    Filed: October 22, 2002
    Date of Patent: August 26, 2008
    Assignee: H. Lundbeck A/S
    Inventors: James A. Bonini, Beth E. Borowsky, Nika Adham, Noel Boyle, Thelma O. Thompson
  • Patent number: 7371535
    Abstract: This invention provides isolated nucleic acids encoding mammalian SNORF33 receptors, purified mammalian SNORF33 receptors, vectors comprising nucleic acid encoding mammalian SNORF33 receptors, cells comprising such vectors, antibodies directed to mammalian SNORF33 receptors, nucleic acid probes useful for detecting nucleic acid encoding mammalian SNORF33 receptors, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding mammalian SNORF33 receptors, transgenic, nonhuman animals which express DNA encoding normal or mutant mammalian SNORF33 receptors, methods of isolating mammalian SNORF33 receptors, methods of treating an abnormality that is linked to the activity of the mammalian SNORF33 receptors, as well as methods of determining binding of compounds to mammalian SNORF33 receptors, methods of identifying agonists and antagonists of SNORF33 receptors, and agonists and antagonists so identified.
    Type: Grant
    Filed: September 1, 2005
    Date of Patent: May 13, 2008
    Assignee: H. Lundbeck A/S
    Inventors: Beth E. Borowsky, Kristine L. Ogozalek, Kenneth A. Jones
  • Patent number: 7276339
    Abstract: This invention provides isolated nucleic acids encoding mammalian NPFF receptors, purified mammalian NPFF receptors, vectors comprising nucleic acid encoding mammalian NPFF receptors, cells comprising such vectors, antibodies directed to mammalian NPFF receptors, nucleic acid probes useful for detecting nucleic acid encoding mammalian NPFF receptors, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding mammalian NPFF receptors, transgenic, nonhuman animals which express DNA encoding normal or mutant mammalian NPFF receptors, methods of isolating mammalian NPFF receptors, methods of treating an abnormality that is linked to the activity of the mammalian NPFF receptors, as well as methods of determining binding of compounds to mammalian NPFF receptors, methods of identifying agonists and antagonists of NPFF receptors, and agonists and antagonists so identified.
    Type: Grant
    Filed: November 18, 2004
    Date of Patent: October 2, 2007
    Assignee: H. Lundbeck A/S
    Inventors: Christophe P. G. Gerald, Kenneth A. Jones, James A. Bonini, Beth E. Borowsky, Douglas A. Craig
  • Patent number: 7252945
    Abstract: This invention provides isolated nucleic acids encoding mammalian NPFF receptors, purified mammalian NPFF receptors, vectors comprising nucleic acid encoding mammalian NPFF receptors, cells comprising such vectors, antibodies directed to mammalian NPFF receptors, nucleic acid probes useful for detecting nucleic acid encoding mammalian NPFF receptors, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding mammalian NPFF receptors, transgenic, nonhuman animals which express DNA encoding normal or mutant mammalian NPFF receptors, methods of isolating mammalian NPFF receptors, methods of treating an abnormality that is linked to the activity of the mammalian NPFF receptors, as well as methods of determining binding of compounds to mammalian NPFF receptors, methods of identifying agonists and antagonists of NPFF receptors, and agonists and antagonists so identified.
    Type: Grant
    Filed: November 18, 2004
    Date of Patent: August 7, 2007
    Assignee: H. Lundbeck A/S
    Inventors: Christophe P. G. Gerald, Kenneth A. Jones, James A. Bonini, Beth E. Borowsky, Douglas A. Craig
  • Patent number: 7037665
    Abstract: This invention provides isolated nucleic acids encoding mammalian SNORF36 receptors, purified mammalian SNORF36 receptors, vectors comprising nucleic acid encoding mammalian SNORF36 receptors, cells comprising such vectors, antibodies directed to mammalian SNORF36 receptors, nucleic acid probes useful for detecting nucleic acid encoding mammalian SNORF36 receptors, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding mammalian SNORF36 receptors, transgenic, nonhuman animals which express DNA encoding normal or mutant mammalian SNORF36 receptors, methods of isolating mammalian SNORF36 receptors, methods of treating an abnormality that is linked to the activity of the mammalian SNORF36 receptors, as well as methods of determining binding of compounds to mammalian SNORF36 receptors, methods of identifying agonists and antagonists of SNORF36 receptors, and agonists and antagonists so identified.
    Type: Grant
    Filed: May 3, 2000
    Date of Patent: May 2, 2006
    Assignee: H. Lundbeck A/S
    Inventors: Beth E. Borowsky, Kristine L. Ogozalek, Parul P. Lakhlani, Nika Adham
  • Patent number: 7029914
    Abstract: This invention provides isolated nucleic acids encoding mammalian SNORF36 receptors, purified mammalian SNORF36 receptors, vectors comprising nucleic acid encoding mammalian SNORF36 receptors, cells comprising such vectors, antibodies directed to mammalian SNORF36 receptors, nucleic acid probes useful for detecting nucleic acid encoding mammalian SNORF36 receptors, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding mammalian SNORF36 receptors, transgenic, nonhuman animals which express DNA encoding normal or mutant mammalian SNORF36 receptors, methods of isolating mammalian SNORF36 receptors, methods of treating an abnormality that is linked to the activity of the mammalian SNORF36 receptors, as well as methods of determining binding of compounds to mammalian SNORF36 receptors, methods of identifying agonists and antagonists of SNORF36 receptors, and agonists and antagonists so identified.
    Type: Grant
    Filed: May 16, 2002
    Date of Patent: April 18, 2006
    Assignee: H. Lundbeck A/S
    Inventors: Beth E. Borowsky, Kristine L. Ogozalek, Parul P. Lakhlani, Nika Adham
  • Patent number: 6987005
    Abstract: This invention provides isolated nucleic acids encoding mammalian SNORF33 receptors, purified mammalian SNORF33 receptors, vectors comprising nucleic acid encoding mammalian SNORF33 receptors, cells comprising such vectors, antibodies directed to mammalian SNORF33 receptors, nucleic acid probes useful for detecting nucleic acid encoding mammalian SNORF33 receptors, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding mammalian SNORF33 receptors, transgenic, nonhuman animals which express DNA encoding normal or mutant mammalian SNORF33 receptors, methods of isolating mammalian SNORF33 receptors, methods of treating an abnormality that is linked to the activity of the mammalian SNORF33 receptors, as well as methods of determining binding of compounds to mammalian SNORF33 receptors, methods of identifying agonists and antagonists of SNORF33 receptors, and agonists and antagonists so identified.
    Type: Grant
    Filed: May 26, 2000
    Date of Patent: January 17, 2006
    Assignee: H. Lundbeck A/S
    Inventors: Beth E. Borowsky, Kristine L. Ogozalek, Kenneth A. Jones
  • Patent number: 6849727
    Abstract: This invention provides isolated nucleic acids encoding mammalian NPFF receptors, purified mammalian NPFF receptors, vectors comprising nucleic acid encoding mammalian NPFF receptors, cells comprising such vectors, antibodies directed to mammalian NPFF receptors, nucleic acid probes useful for detecting nucleic acid encoding mammalian NPFF receptors, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding mammalian NPFF receptors, transgenic, nonhuman animals which express DNA encoding normal or mutant mammalian NPFF receptors, methods of isolating mammalian NPFF receptors, methods of treating an abnormality that is linked to the activity of the mammalian NPFF receptors, as well as methods of determining binding of compounds to mammalian NPFF receptors, methods of identifying agonists and antagonists of NPFF receptors, and agonists and antagonists so identified.
    Type: Grant
    Filed: March 29, 2000
    Date of Patent: February 1, 2005
    Assignee: H.Lundbeck A/S
    Inventors: Christophe P. G. Gerald, Kenneth A. Jones, James A. Bonini, Beth E. Borowsky, Douglas A. Craig
  • Patent number: 6709831
    Abstract: This invention provides isolated nucleic acids encoding mammalian NPFF receptors, purified mammalian NPFF receptors, vectors comprising nucleic acid encoding mammalian NPFF receptors, cells comprising such vectors, antibodies directed to mammalian NPFF receptors, nucleic acid probes useful for detecting nucleic acid encoding mammalian NPFF receptors, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding mammalian NPFF receptors, transgenic, nonhuman animals which express DNA encoding normal or mutant mammalian NPFF receptors, methods of isolating mammalian NPFF receptors, methods of treating an abnormality that is linked to the activity of the mammalian NPFF receptors, as well as methods of determining binding of compounds to mammalian NPFF receptors, methods of identifying agonists and antagonists of NPFF receptors, and agonists and antagonists so identified.
    Type: Grant
    Filed: September 24, 1999
    Date of Patent: March 23, 2004
    Assignee: Synaptic Pharmaceutical Corporation
    Inventors: Christophe P. G. Gerald, Kenneth A. Jones, James A. Bonini, Beth E. Borowsky, Douglas A. Craig
  • Publication number: 20030176685
    Abstract: This invention provides a recombinant nucleic acid comprising a nucleic acid encoding a mammalian SNORF7 receptor, wherein the mammalian receptor-encoding nucleic acid hybridizes under high stringency conditions to (a) a nucleic acid encoding a human SNORF7 receptor and having a sequence comprising the sequence of the human SNORF7 nucleic acid contained in plasmid pCR2.1-hSNORF7-p (ATCC Accession No. 203778), (b) a nucleic acid encoding a rat SNORF7 receptor and having a sequence identical to the sequence of the rat SNORF7 receptor-encoding nucleic acid contained in plasmid pEXJ.T7-rSNORF7-f (ATCC Accession No. 203777), or (c) nucleic acid encoding a human SNORF7 receptor and having a sequence identical to the sequence of the human SNORF7 receptor-encoding nucleic acid contained in plasmid pEXJ.T73BS-hSNORF7-f ATCC Patent Depository No. PTA-426).
    Type: Application
    Filed: May 7, 2002
    Publication date: September 18, 2003
    Inventors: Beth E. Borowsky, Hla Kyaw, James A. Bonini
  • Publication number: 20030158401
    Abstract: This invention provides a recombinant nucleic acid comprising a nucleic acid encoding a mammalian SNORF13 receptor, wherein the mammalian receptor-encoding nucleic acid hybridizes under high stringency conditions to a nucleic acid encoding a human SNORF13 receptor and having a sequence identical to the sequence of either one of the human SNORF13a receptor-encoding nucleic acid contained in plasmid pEXJ.T3T7hSNORF13a-f (Patent Deposit Designation No. PTA-______), the human SNORF13b receptor-encoding nucleic acid contained in plasmid pEXJ.T3T7-hSNORF13b-f (Patent Deposit Designation No. PTA-______), the human SNORF13c receptor-encoding nucleic acid contained in plasmid pEXJ.T3T7-hSNORF13c-f (Patent Deposit Designation No. PTA-______), or the human SNORF13d receptor-encoding nucleic acid contained in plasmid pEXJ.T3T7-hSNORF13d-f (Patent Deposit Designation No.
    Type: Application
    Filed: October 21, 2002
    Publication date: August 21, 2003
    Inventors: Marie Sudam Pathirana, Kristine L. Ogozalek, Beth E. Borowsky, James A. Bonini, Kelli E. Smith
  • Publication number: 20030139590
    Abstract: This invention provides isolated nucleic acids encoding mammalian SNORF25 receptors, purified mammalian SNORF25 receptors, vectors comprising nucleic acid encoding mammalian SNORF25 receptors, cells comprising such vectors, antibodies directed to mammalian SNORF25 receptors, nucleic acid probes useful for detecting nucleic acid encoding mammalian SNORF25 receptors, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding mammalian SNORF25 receptors, transgenic, nonhuman animals which express DNA encoding normal or mutant mammalian SNORF25 receptors, methods of isolating mammalian SNORF25 receptors, methods of treating an abnormality that is linked to the activity of the mammalian SNORF25 receptors, as well as methods of determining binding of compounds to mammalian SNORF25 receptors, methods of identifying agonists and antagonists of SNORF25 receptors, and agonists and antagonists so identified.
    Type: Application
    Filed: October 22, 2002
    Publication date: July 24, 2003
    Applicant: Synaptic Pharmaceutical Corporation
    Inventors: James A. Bonini, Beth E. Borowsky, Nika Adham, Noel Boyle, Thelma O. Thompson
  • Publication number: 20030130493
    Abstract: This invention provides isolated nucleic acids encoding mammalian Edg7 receptors, purified mammalian Edg7 receptors, vectors comprising nucleic acid encoding mammalian Edg7 receptors, cells comprising such vectors, antibodies directed to mammalian Edg7 receptors, nucleic acid probes useful for detecting nucleic acid encoding mammalian Edg7 receptors, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding mammalian Edg7 receptors, transgenic, nonhuman animals which express DNA encoding normal or mutant mammalian Edg7 receptors, methods of isolating mammalian Edg7 receptors, methods of treating an abnormality that is linked to the activity of the mammalian Edg7 receptors, as well as methods of determining binding of compounds to mammalian Edg7 receptors, methods of identifying agonists and antagonists of Edg7 receptors, and agonists and antagonists so identified.
    Type: Application
    Filed: August 26, 2002
    Publication date: July 10, 2003
    Inventors: James A. Bonini, Ling Yan Huang, Beth E. Borowsky, John A. Salon, Amy Wilson, Raisa Nagorny
  • Publication number: 20030125539
    Abstract: This invention provides isolated nucleic acids encoding mammalian SNORF25 receptors, purified mammalian SNORF25 receptors, vectors comprising nucleic acid encoding mammalian SNORF25 receptors, cells comprising such vectors, antibodies directed to mammalian SNORF25 receptors, nucleic acid probes useful for detecting nucleic acid encoding mammalian SNORF25 receptors, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding mammalian SNORF25 receptors, transgenic, nonhuman animals which express DNA encoding normal or mutant mammalian SNORF25 receptors, methods of isolating mammalian SNORF25 receptors, methods of treating an abnormality that is linked to the activity of the mammalian SNORF25 receptors, as well as methods of determining binding of compounds to mammalian SNORF25 receptors, methods of identifying agonists and antagonists of SNORF25 receptors, and agonists and antagonists so identified.
    Type: Application
    Filed: October 22, 2002
    Publication date: July 3, 2003
    Applicant: Synaptic Pharmaceutical Corporation
    Inventors: James A. Bonini, Beth E. Borowsky, Nika Adham, Noel Boyle, Thelma O. Thompson
  • Publication number: 20030109695
    Abstract: This invention provides a recombinant nucleic acid comprising a nucleic acid encoding a mammalian SNORF7 receptor, wherein the mammalian receptor-encoding nucleic acid hybridizes under high stringency conditions to (a) a nucleic acid encoding a human SNORF7 receptor and having a sequence comprising the sequence of the human SNORF7 nucleic acid contained in plasmid pCR2.1-hSNORF7-p (ATCC Accession No. 203778), (b) a nucleic acid encoding a rat SNORF7 receptor and having a sequence identical to the sequence of the rat SNORF7 receptor-encoding nucleic acid contained in plasmid pEXJ.T7-rSNORF7-f (ATCC Accession No. 203777), or (c) nucleic acid encoding a human SNORF7 receptor and having a sequence identical to the sequence of the human SNORF7 receptor-encoding nucleic acid contained in plasmid pEXJ.T73BS-hSNORF7-f ATCC Patent Depository No. PTA-426).
    Type: Application
    Filed: November 6, 2002
    Publication date: June 12, 2003
    Inventors: Beth E. Borowsky, Hla Kyaw, James A. Bonini
  • Publication number: 20030105318
    Abstract: This invention provides isolated nucleic acids encoding mammalian SNORF33 receptors, purified mammalian SNORF33 receptors, vectors comprising nucleic acid encoding mammalian SNORF33 receptors, cells comprising such vectors, antibodies directed to mammalian SNORF33 receptors, nucleic acid probes useful for detecting nucleic acid encoding mammalian SNORF33 receptors, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding mammalian SNORF33 receptors, transgenic, nonhuman animals which express DNA encoding normal or mutant mammalian SNORF33 receptors, methods of isolating mammalian SNORF33 receptors, methods of treating an abnormality that is linked to the activity of the mammalian SNORF33 receptors, as well as methods of determining binding of compounds to mammalian SNORF33 receptors, methods of identifying agonists and antagonists of SNORF33 receptors, and agonists and antagonists so identified.
    Type: Application
    Filed: October 7, 2002
    Publication date: June 5, 2003
    Applicant: Synpatic Pharmaceutical Corporation
    Inventors: Beth E. Borowsky, Kristine L. Ogozalek, Kenneth A. Jones
  • Publication number: 20030083488
    Abstract: This invention provides a recombinant nucleic acid comprising a nucleic acid encoding a mammalian SNORF66 receptor, wherein the mammalian receptor-encoding nucleic acid hybridizes under high stringency conditions to a nucleic acid encoding a human SNORF66 receptor and having a sequence identical to the sequence of the human SNORF66 receptor-encoding nucleic acid contained in plasmid pcDNA3.1-hSNORF66-f (Patent Deposit Designation No. PTA ______). This invention further provides a recombinant nucleic acid comprising a nucleic acid encoding a human SNORF66 receptor, wherein the human SNORF66 receptor comprises an amino acid sequence identical to the sequence of the human SNORF66 receptor encoded by the shortest open reading frame indicated in FIGS. 1A-1B (SEQ ID NO: 1).
    Type: Application
    Filed: December 2, 2002
    Publication date: May 1, 2003
    Applicant: Synaptic Pharmaceutical Corporation
    Inventors: Beth E. Borowsky, James A. Bonini, Christophe Gerald
  • Publication number: 20030078407
    Abstract: This invention provides a recombinant nucleic acid comprising a nucleic acid encoding a mammalian SNORF53 receptor, wherein the mammalian receptor-encoding nucleic acid hybridizes under high stringency conditions to a nucleic acid encoding a human SNORF53 receptor and having a sequence identical to the sequence of the human SNORF53 receptor-encoding nucleic acid contained in plasmid pEXJ-hSNORF53-f (Patent Deposit Designation No. PTA ______). This invention further provides a recombinant nucleic acid comprising a nucleic acid encoding a human SNORF53 receptor, wherein the human SNORF53 receptor comprises an amino acid sequence identical to the sequence of the human SNORF53 receptor encoded by the shortest open reading frame indicated in FIGS. 1A-1E (SEQ ID NO: 1).
    Type: Application
    Filed: August 30, 2002
    Publication date: April 24, 2003
    Inventors: Kelli E. Smith, Kellie M. Boitz, Kristine L. Ogozalek, Beth E. Borowsky
  • Publication number: 20030073167
    Abstract: This invention provides isolated nucleic acids encoding mammalian SNORF36 receptors, purified mammalian SNORF36 receptors, vectors comprising nucleic acid encoding mammalian SNORF36 receptors, cells comprising such vectors, antibodies directed to mammalian SNORF36 receptors, nucleic acid probes useful for detecting nucleic acid encoding mammalian SNORF36 receptors, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding mammalian SNORF36 receptors, transgenic, nonhuman animals which express DNA encoding normal or mutant mammalian SNORF36 receptors, methods of isolating mammalian SNORF36 receptors, methods of treating an abnormality that is linked to the activity of the mammalian SNORF36 receptors, as well as methods of determining binding of compounds to mammalian SNORF36 receptors, methods of identifying agonists and antagonists of SNORF36 receptors, and agonists and antagonists so identified.
    Type: Application
    Filed: May 16, 2002
    Publication date: April 17, 2003
    Applicant: Synaptic Pharmaceutical Corporation
    Inventors: Beth E. Borowsky, Kristine L. Ogozalek, Parul P. Lakhlani, Nika Adham