Abstract: Absorbent articles with front and rear opening features are disclosed. An article may comprise an insert comprising an outer cover, a liner, and a core between the outer cover and liner, a first waist panel coupled to the insert throughout a first attachment region, and a second waist panel coupled to the insert throughout a second attachment region, the second panel being coupled to the first panel proximate a first side edge of the article and the second side edge of the article and further comprising a weakened region. The second attachment may comprise a low-strength attachment zone and a high-strength attachment zone, the high-strength attachment zone disposed proximate the attachment region bottom edge. The low-strength attachment zone may further have a first peel strength and the high-strength attachment zone may have a second peel strength, the second peel strength greater than the first.

Abstract: Absorbent articles with front and rear opening features are disclosed. An article may comprise an absorbent insert comprising an outer cover, a liner, and a core between the outer cover and liner, a first waist panel coupled to the insert and having a first waist panel bottom edge, a first waist panel top edge, a first waist panel outer surface, and a first waist panel inner surface, and a second waist panel coupled to the insert. The first waist panel may be coupled to the second waist panel along side edges of the article, and the first waist panel may further comprise a weakened region comprising weakened portions extending at least partially between the first waist panel bottom edge and the first waist panel top edge. The weakened region may have a weakened region percentage of between about 45% and about 90%.

Abstract: Absorbent articles with front and rear opening features are disclosed. An article may comprise an absorbent insert comprising an outer cover, a liner, and an absorbent core between the outer cover and the liner, a first waist panel coupled to the insert and comprising a weakened region and first waist band portion and first chassis portion, the first waist band portion and first chassis portion comprising elastic elements, and a second waist panel. The first waist panel may be bonded to the second along side edges of the article. One of the elastic elements of the first waistband portion may be spaced laterally from a second one forming a waistband non-elasticized region laterally between the first one of the elastic elements and the second one of the elastic elements, and the weakened region may extend at least partially through the waistband non-elasticized region.

Abstract: Absorbent articles with front and rear opening features are disclosed. An article may comprise an absorbent insert comprising an outer cover, a liner, and a core between the outer cover and liner, a first waist panel coupled to the insert and having a first waist panel bottom edge, a first waist panel top edge, a first waist panel outer surface, and a first waist panel inner surface, and a second waist panel coupled to the insert. The first waist panel may be coupled to the second waist panel along side edges of the article, and the first waist panel may further comprise a weakened region comprising weakened portions extending at least partially between the first waist panel bottom edge and the first waist panel top edge. The weakened region may have a weakened region percentage of between about 45% and about 90%.

Abstract: Absorbent articles with front and rear opening features are disclosed. An article may comprise an absorbent insert comprising an outer cover, a liner, and an absorbent core between the outer cover and the liner, a first waist panel coupled to the insert and comprising a weakened region and first waist band portion and first chassis portion, the first waist band portion and first chassis portion comprising elastic elements, and a second waist panel. The first waist panel may be bonded to the second along side edges of the article. One of the elastic elements of the first waistband portion may be spaced laterally from a second one forming a waistband non-elasticized region laterally between the first one of the elastic elements and the second one of the elastic elements, and the weakened region may extend at least partially through the waistband non-elasticized region.

Abstract: Absorbent articles with front and rear opening features are disclosed. An article may comprise an insert comprising an outer cover, a liner, and a core between the outer cover and liner, a first waist panel coupled to the insert throughout a first attachment region, and a second waist panel coupled to the insert throughout a second attachment region, the second panel being coupled to the first panel proximate a first side edge of the article and the second side edge of the article and further comprising a weakened region. The second attachment may comprise a low-strength attachment zone and a high-strength attachment zone, the high-strength attachment zone disposed proximate the attachment region bottom edge. The low-strength attachment zone may further have a first peel strength and the high-strength attachment zone may have a second peel strength, the second peel strength greater than the first.

Abstract: Successful CNS drug discovery requires a scalable, highly physiological neuronal model. Using directed differentiation of mouse embryonic stem (mES) cells, including mES cells isolated from a mouse model of Alzheimer's disease (AD), a highly homogeneous primary neuronal model amenable to phenotypic assays for production and synaptotoxicity of amyloid ?-peptide was developed. This model furnishes a highly physiological and AD-relevant platform suitable for high throughput small molecule and functional genetic screens, providing specific small molecule compounds identified by such screens.

Abstract: A breast shield cover designed to hold a breast shield in place during breast pumping without the wearer having to hold the breast shield in place.

Abstract: A nursing brassier with at least 2 locations for each breast cup where attachment mechanisms are used to facilitate the detachment and re-attachment of the breast cup, in order to allow nursing and comfort to the nursing mother.

Abstract: Successful CNS drug discovery requires a scalable, highly physiological neuronal model. Using directed differentiation of mouse embryonic stem (mES) cells, including mES cells isolated from a mouse model of Alzheimer's disease (AD), a highly homogeneous primary neuronal model amenable to phenotypic assays for production and synaptotoxicity of amyloid ?-peptide was developed. This model furnishes a highly physiological and AD-relevant platform suitable for high throughput small molecule and functional genetic screens, providing specific small molecule compounds identified by such screens.

Abstract: The present invention relates to the use of agents that inhibit the toxic effects of amyloid oligomers by increasing intracellular levels of phosphoinositol 4-phosphate (PI(4)P, or “PIP”) and/or phosphotidylinositol 4,5-biphosphate (PI(4,5)P2 or “PIP2”), the use of such agents for the treatment of neurodegenerative diseases, methods of treating neurodegenerative diseases by administration of agents which alter lipid metabolism, and methods of identifying agents which alter the association of presenilins with ?-secretase and lipid rafts.

Abstract: The present invention relates to the use of agents that inhibit the toxic effects of amyloid oligomers by increasing intracellular levels of phosphoinositol 4-phosphate (PI(4)P, or “PIP”) and/or phosphotidylinositol 4,5-biphosphate (PI(4,5)P2 or “PIP2”), the use of such agents for the treatment of neurodegenerative diseases, methods of treating neurodegenerative diseases by administration of agents which alter lipid metabolism, and methods of identifying agents which alter the association of presenilins with ?-secretase and lipid rafts.

Abstract: A method of providing an interactive product system includes selecting a plurality of character images, each character image associated with a unique characteristic selected from a set of unique characteristics, manufacturing a plurality of products, each product having at least one of the character images displayed thereon, and displaying information to a caregiver about at least one of the character images and the unique characteristic that is associated therewith, whereby the caregiver is prompted to interact with a child when the caregiver observes the at least one character images on the product. An interactive product system including the plurality of products and the informational display is also included.

Abstract: A noncaustic system for cleaning and controlling bacteria growth in fluid supply lines, containers, or on objects. The system includes an electrolytic cell generating aqueous solutions of supersaturated oxygen via electrolytic chemistry. The electrolyzed or treated water has both cleaning and antimicrobial effects when dispensed in fluid supply lines having beverage deposits, a layer or coating of bacteria, yeast, microorganisms or polysaccharide layers formed therein. The present invention further increases the germicidal activity of the above system toward microorganisms that may adhere and grow on the interior surfaces of the fluid supply line.

Abstract: A method of using a wireless scheduling device to determine schedule availability for a set of attendees includes communicating an availability request to a server using the wireless scheduling device. The server has access to calendar data for each attendee on the set of attendees. In response to the availability request, a search is conducted of the calendar data of each attendee to produce an availability data set. The availability data set is transmitted to the wireless scheduling device. The availability data set may then be displayed on the wireless scheduling device.