Abstract: Nanohybrid polymer conjugates that provide a “platform” delivery system is disclosed. The delivery platform provides a multi-focused therapeutic regimen that may be tailored to combat a host of cancers, including advanced-stage, therapy-resistant tumors. The nanohybrids of the instant invention incorporate a configurable polymeric backbone, are multivalent (e.g., may incorporate several targeting ligands), and have the capacity to carry multiple classes of “payloads” (e.g., alpha-, beta-, gamma- and positron-emitting isotopes). The polymer conjugates comprise a single molecular species that can be useful not only in diagnostic assessment, but also in tailoring therapies to suit a variety of cancers.