Patents by Inventor Bethany Gray

Bethany Gray has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTIDOTE-MEDIATED REVERSAL OF EXTRACELLULAR APTAMER STAINING
    Publication number: 20240141430
    Abstract: Provided herein are compositions and methods for sorting and/or identifying live cells. The compositions and methods provide for staining of live cells with aptamer so particular cells can be identified within or sorted from a heterogeneous population of live cells and subsequent reversal of the staining to prepare sorted and/or identified cells in their native state.
    Type: Application
    Filed: March 30, 2023
    Publication date: May 2, 2024
    Inventors: Bruce Sullenger, Bethany Gray, Michael Nichols
  • Nucleolin-targeting aptamers and methods of using the same
    Patent number: 11713464
    Abstract: Provided herein are compositions including aptamers capable of binding to and/or inhibiting the activity of nucleolin. Methods of treating cancer in a subject by administering such compositions are also provided.
    Type: Grant
    Filed: September 10, 2018
    Date of Patent: August 1, 2023
    Assignee: Duke University
    Inventors: Bruce A. Sullenger, Michael Goldstein, Elizabeth D. Pratico, Michael Kastan, Bethany Gray
  • Antidote-mediated reversal of extracellular aptamer staining
    Patent number: 11634772
    Abstract: Provided herein are compositions and methods for sorting and/or identifying live cells. The compositions and methods provide for staining of live cells with aptamer so particular cells can be identified within or sorted from a heterogeneous population of live cells and subsequent reversal of the staining to prepare sorted and/or identified cells in their native state.
    Type: Grant
    Filed: March 23, 2018
    Date of Patent: April 25, 2023
    Assignee: Duke University
    Inventors: Bruce Sullenger, Bethany Gray, Michael Nichols
  • NUCLEOLIN-TARGETING APTAMERS AND METHODS OF USING THE SAME
    Publication number: 20200283773
    Abstract: Provided herein are compositions including aptamers capable of binding to and/or inhibiting the activity of nucleolin. Methods of treating cancer in a subject by administering such compositions are also provided.
    Type: Application
    Filed: September 10, 2018
    Publication date: September 10, 2020
    Applicant: Duke University
    Inventors: Bruce A. Sullenger, Michael Goldstein, Elizabeth D. Pratico, Michael Kastan, Bethany Gray
  • ANTIDOTE-MEDIATED REVERSAL OF EXTRACELLULAR APTAMER STAINING
    Publication number: 20200095636
    Abstract: Provided herein are compositions and methods for sorting and/or identifying live cells. The compositions and methods provide for staining of live cells with aptamer so particular cells can be identified within or sorted from a heterogeneous population of live cells and subsequent reversal of the staining to prepare sorted and/or identified cells in their native state.
    Type: Application
    Filed: March 23, 2018
    Publication date: March 26, 2020
    Applicant: Duke University
    Inventors: Bruce Sullenger, Bethany Gray, Michael Nichols