Patents by Inventor Bethany Janowski

Bethany Janowski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD FOR SINGLE CELL SEQUENCING OF MIRNAS AND OTHER CELLULAR RNAS
    Publication number: 20150284716
    Abstract: Provided herein are methods for single cell sequencing of miRNAs and other low abundance and/or or short cellular RNAs.
    Type: Application
    Filed: February 17, 2015
    Publication date: October 8, 2015
    Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: David Corey, Yongjun Chu, Bethany Janowski
  • MODULATING GENE EXPRESSION WITH agRNA AND GAPMERS TARGETING ANTISENSE TRANSCRIPTS
    Publication number: 20150064709
    Abstract: Gene expression is selectively modulated in the genome of a mammalian cell determined to be in need thereof by determining the presence of an encoded antisense transcript overlapping a promoter of the target gene; contacting the transcript with an agRNA or gapmer complementary to a portion of the transcript upstream relative to the transcription start site of the gene; and detecting a resultant modulation of expression of the target gene.
    Type: Application
    Filed: September 10, 2014
    Publication date: March 5, 2015
    Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Jacob C. SCHWARTZ, Scott T. YOUNGER, Bethany A. JANOWSKI, David R. COREY
  • Modulation of gene expression by oligomers targeted to chromosomal DNA
    Patent number: 8324181
    Abstract: Synthesis of a target transcript of a gene is selectively increased in a mammalian cell by contacting the cell with a polynucleotide oligomer of 12-28 bases complementary to a region within a target promoter of the gene under conditions whereby the oligomer selectively increases synthesis of the target transcript.
    Type: Grant
    Filed: March 30, 2010
    Date of Patent: December 4, 2012
    Assignee: Board of Regents, The University of Texas System
    Inventors: David R. Corey, David S. Shames, Bethany A. Janowski, John D. Minna
  • Modulating Gene Expression With agRNA and Gapmers Targeting Antisense Transcripts
    Publication number: 20120288869
    Abstract: Gene expression is selectively modulated in the genome of a mammalian cell determined to be in need thereof by determining the presence of an encoded antisense transcript overlapping a promoter of the target gene; contacting the transcript with an agRNA or gapmer complementary to a portion of the transcript upstream relative to the transcription start site of the gene; and detecting a resultant modulation of expression of the target gene.
    Type: Application
    Filed: July 3, 2012
    Publication date: November 15, 2012
    Inventors: Jacob C. Schwartz, Scott T. Younger, Bethany A. Janowski, David R. Corey
  • Modulation of gene expression by oligomers targeted to chromosomal DNA
    Patent number: 7709456
    Abstract: Synthesis of a target transcript of a gene is selectively increased in a mammalian cell by contacting the cell with a polynucleotide oligomer of 12-28 bases complementary to a region within a target promoter of the gene under conditions whereby the oligomer selectively increases synthesis of the target transcript.
    Type: Grant
    Filed: November 13, 2006
    Date of Patent: May 4, 2010
    Assignee: Board of Regents, The University of Texas System
    Inventors: David R. Corey, David S. Shames, Bethany A. Janowski, John D. Minna
  • Modulating Gene Expression with agRNA and Gapmers Targeting Antisense Transcripts
    Publication number: 20090092988
    Abstract: Gene expression is selectively modulated in the genome of a mammalian cell determined to be in need thereof by determining the presence of an encoded antisense transcript overlapping a promoter of the target gene; contacting the transcript with an agRNA or gapmer complementary to a portion of the transcript upstream relative to the transcription start site of the gene; and detecting a resultant modulation of expression of the target gene.
    Type: Application
    Filed: October 6, 2008
    Publication date: April 9, 2009
    Inventors: Jacob C. Schwartz, Scott T. Younger, Bethany A. Janowski, David R. Corey
  • Modulation of gene expression by oligomers targeted to chromosomal DNA
    Publication number: 20070111963
    Abstract: Synthesis of a target transcript of a gene is selectively increased in a mammalian cell by contacting the cell with a polynucleotide oligomer of 12-28 bases complementary to a region within a target promoter of the gene under conditions whereby the oligomer selectively increases synthesis of the target transcript.
    Type: Application
    Filed: November 13, 2006
    Publication date: May 17, 2007
    Inventors: David Corey, Bethany Janowski, David Shames, John Minna
  • Antigene oligomers inhibit transcription
    Publication number: 20060205635
    Abstract: Transcription of a gene in a mammalian cell is methylase-independently inhibited by contacting the cell with a nucleic acid oligomer of 12-28 bases complementary for a partially single-stranded target genomic sequence of the gene.
    Type: Application
    Filed: March 14, 2006
    Publication date: September 14, 2006
    Inventors: David Corey, Bethany Janowski
  • Method of screening oxysterol activation of LXR?
    Patent number: 6893830
    Abstract: The present invention provides a method of screening for agonists of an oxycholesterol activator of LXR? transcription, comprising the steps of: introducing a reporter construct and an LXR expression construct into a host cell; treating the host cell with potential LXR-specific ligands; and identifying compounds which activate LXR? transcription. Also provided is a method of screening for antagonists of an oxycholesterol activator of LXR? transcription, comprising the steps of: introducing a reporter construct and an LXR expression construct into a host cell; pretreating the host cell with activators of LXR? transcription; contacting the host cell with potential antagonists of LXR? transcription; and identifying compounds which block the activation the LXR? transcription.
    Type: Grant
    Filed: June 23, 2000
    Date of Patent: May 17, 2005
    Assignee: The Board of Regents of the University of Texas System
    Inventors: Bethany A. Janowski, David John Mangelsdorf