Patents by Inventor Bethany M. McElroy

Bethany M. McElroy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for removing dimethoxytrityl groups from oligonucleotides
    Patent number: 6794502
    Abstract: The present invention discloses improved methods for oligonucleotide synthesis and purification. In the methods of the invention, a half-life is determined for deprotection of the 5′-OH protecting group at the 5′-terminus of an oligonucleotide post-synthesis. The half-life is used to determine an optimal reaction time for removal of the 5′-OH protecting group. The methods of the invention are amenable to the large-scale synthesis and purification of oligonucleotides.
    Type: Grant
    Filed: March 22, 2002
    Date of Patent: September 21, 2004
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Achim H. Krotz, Bethany M. McElroy, Anthony N. Scozzari
  • Methods for removing dimethoxytrityl groups from oligonucleotides
    Publication number: 20020156268
    Abstract: The present invention discloses improved methods for oligonucleotide synthesis and purification. In the methods of the invention, a half-life is determined for deprotection of the 5′-OH protecting group at the 5′-terminus of an oligonucleotide post-synthesis. The half-life is used to determine an optimal reaction time for removal of the 5′-OH protecting group. The methods of the invention are amenable to the large-scale synthesis and purification of oligonucleotides.
    Type: Application
    Filed: March 22, 2002
    Publication date: October 24, 2002
    Inventors: Achim H. Krotz, Bethany M. McElroy, Anthony N. Scozzari
  • Methods for removing dimethoxytrityl groups from oligonucleotides
    Patent number: 6399765
    Abstract: The present invention discloses improved methods for oligonucleotide synthesis and purification. In the methods of the invention, a half-life is determined for deprotection of the 5′-OH protecting group at the 5′-terminus of an oligonucleotide post-synthesis. The half-life is used to determine an optimal reaction time for removal of the 5′-OH protecting group. The methods of the invention are amenable to the large-scale synthesis and purification of oligonucleotides.
    Type: Grant
    Filed: March 17, 1999
    Date of Patent: June 4, 2002
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Achim H. Krotz, Bethany M. McElroy, Anthony N. Scozzari