Abstract: Medical guidelines are generated based on the history of the medical records for a large patient population, which includes creating a patient trajectory graph from the records including nodes and edges by automatically clustering patients based on relevant the patients' features included in their medical records. The nodes are scored based on the time patients remain with the nodes and desirability of any associated outcomes, resulting in edge scores derived from the scores of the edge-connected nodes. Top ranked interventions obtained from the edge scores that evaluates whether a transition from one node to another is better or worse are included in the generated medical guidelines. Additionally, effect sizes and confidence intervals of medical treatments for a pre-defined patient population are estimated by using the patients' medical records and dividing the population in an exposed and non-exposed group. Estimates are based on match choices between exposed and non-exposed patients.