Patents by Inventor Betsy C. Herold

Betsy C. Herold has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of using HSV-2 single cycle virus delta-gD and HSV-2 recombinant glycoprotein D
    Patent number: 11684670
    Abstract: Methods of vaccinating, immunizing and/or treating a subject against a herpes simplex virus infection or a disease caused by a herpes simplex virus infection comprise administering to the subject an effective amount of a HSV-2 single-cycle virus and an effective amount of a recombinant HSV-2 glycoprotein D, wherein the HSV-2 single-cycle virus comprises HSV-2 having a deletion of glycoprotein D-encoding gene in the genome and the HSV-2 is phenotypically complemented with an HSV-1 glycoprotein D on a lipid bilayer of the HSV-2.
    Type: Grant
    Filed: June 1, 2021
    Date of Patent: June 27, 2023
    Assignee: ALBERT EINSTEIN COLLEGE OF MEDICINE
    Inventors: Betsy C. Herold, Clare Burn Aschner
  • METHOD OF TREATING AND PREVENTING OCULAR DISEASE WITH HSV-2 DELTA GD
    Publication number: 20230111803
    Abstract: Methods of treating or preventing ocular disease caused by herpes simplex virus-1 infection are provided, and comprise administering to a subject an effective amount of a herpes simplex virus-2 (HSV-2) having a deletion of an HSV-2 glycoprotein D-encoding gene in the genome to treat or prevent ocular disease in the subject, wherein the HSV-2 is phenotypically complemented with an HSV-1 glycoprotein D by propagating the HSV-2 in a complementing cell expressing the HSV-1 glycoprotein D.
    Type: Application
    Filed: April 7, 2021
    Publication date: April 13, 2023
    Inventor: Betsy C. Herold
  • Prevention and treatment of viral infections
    Patent number: 11382919
    Abstract: Methods and compositions are provided for inhibiting or treating a viral infection in a subject using cell-impermeable inhibitors of Akt, scramblase and/or a phosphatidylserine.
    Type: Grant
    Filed: November 27, 2018
    Date of Patent: July 12, 2022
    Assignee: ALBERT EINSTEIN COLLEGE OF MEDICINE
    Inventors: Betsy C. Herold, Steven C. Almo, Natalia Cheshenko, Jeffrey Bryan Bonanno
  • MONOCLONAL ANTIBODIES FOR PREVENTION AND TREATMENT OF HERPES SIMPLEX VIRAL INFECTIONS
    Publication number: 20220162291
    Abstract: Provided are antibodies and antigen-binding fragments which bind to herpes simplex virus-2 (HSV-2), methods of use employing the antibodies and/or antigen-binding fragments, and pharmaceutical compositions comprising the antibodies and/or antigen-binding fragments.
    Type: Application
    Filed: March 19, 2020
    Publication date: May 26, 2022
    Inventors: Betsy C. HEROLD, Garnett KELSOE, Masayuki KURAOKA, Clare BURN, William R. Jacobs, Jr.
  • METHODS OF USING HSV-2 SINGLE CYCLE VIRUS DELTA-GD AND HSV-2 RECOMBINANT GLYCOPROTEIN D
    Publication number: 20210369838
    Abstract: Methods of vaccinating, immunizing and/or treating a subject against a herpes simplex virus infection or a disease caused by a herpes simplex virus infection comprise administering to the subject an effective amount of a HSV-2 single-cycle virus and an effective amount of a recombinant HSV-2 glycoprotein D, wherein the HSV-2 single-cycle virus comprises HSV-2 having a deletion of glycoprotein D-encoding gene in the genome and the HSV-2 is phenotypically complemented with an HSV-1 glycoprotein D on a lipid bilayer of the HSV-2.
    Type: Application
    Filed: June 1, 2021
    Publication date: December 2, 2021
    Inventors: Betsy C. HEROLD, Clare Burn Aschner
  • PREVENTION AND TREATMENT OF VIRAL INFECTIONS
    Publication number: 20200383994
    Abstract: Methods and compositions are provided for inhibiting or treating a viral infection in a subject using cell-impermeable inhibitors of Akt, scramblase and/or a phosphatidylserine.
    Type: Application
    Filed: November 27, 2018
    Publication date: December 10, 2020
    Inventors: Betsy C. Herold, Steven C. Almo, Natalia Cheshenko, Jeffrey Bryan Bonanno