Patents by Inventor Bette Korber

Bette Korber has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Mosaic HIV-1 envelopes to induce ADCC responses
    Patent number: 11773144
    Abstract: The invention is directed to mosaic HIV-1 envelopes, and methods of using the same to induce ADCC responses.
    Type: Grant
    Filed: October 2, 2018
    Date of Patent: October 3, 2023
    Assignees: DUKE UNIVERSITY, LOS ALAMOS NATIONAL SECURITY, LLC
    Inventors: Bette Korber, Sandrasegaram Gnanakaran, Guido Ferrari, Barton F. Haynes
  • HEPATITIS B VIRUS VACCINES
    Publication number: 20220288195
    Abstract: The present disclosure relates to isolated polynucleotides and polypeptides, and related hepatitis B virus (HBV)vaccines. The present disclosure also relates to viral vectors for expressing such polypeptides, and which may be used in HBV vaccines, as well as methods of protecting a subject from HBV infection and methods of treating HBV in a subject comprising administering the polypeptides, vectors, or vaccines described herein. Methods of designing and producing an HBV vaccine comprising designing vaccine antigens to cover the diversity within a geographic area using an antigen amino acid sequence that efficiently covers the epitopes in the HBV genotypes present in the geographic area are also provided herein.
    Type: Application
    Filed: August 28, 2020
    Publication date: September 15, 2022
    Inventors: Eric BRUENING, Janet DOUGLAS, Emily MARSHALL, Karina YUSIM, Bette KORBER, James THEILER
  • MOSAIC HIV-1 ENVELOPES TO INDUCE ADCC RESPONSES
    Publication number: 20210139544
    Abstract: The invention is directed to mosaic HIV-1 envelopes, and methods of using the same to induce ADCC responses.
    Type: Application
    Filed: October 2, 2018
    Publication date: May 13, 2021
    Inventors: Bette Korber, Sandrasegaram Gnanakaran, Guido Ferrari, Barton F. Haynes
  • NUCLEIC ACID SEQUENCES ENCODING EXPANDABLE HIV MOSAIC PROTEINS
    Publication number: 20120219583
    Abstract: The invention is directed to a nucleic acid molecule encoding a HIV-1 polypeptide which comprises the nucleic acid sequence of SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, or SEQ ID NO: 4. The invention also provides a method of inducing an immune response against HIV-1 in a mammal.
    Type: Application
    Filed: October 15, 2010
    Publication date: August 30, 2012
    Applicants: Los Alamos National Security, LLC, The U.S. of America, as rep. by the Sec., Dept. of HHS
    Inventors: Gary J. Nabel, Zhi-Yong Yang, Wing-Pui Kong, Bette Korber
  • Consensus/ancestral immunogens
    Publication number: 20070178562
    Abstract: The present invention relates, in general, to an immunogen and, in particular, to an immunogen for inducing antibodies that neutralizes a wide spectrum of HIV primary isolates and/or to an immunogen that induces a T cell immune response. The invention also relates to a method of inducing anti-HIV antibodies, and/or to a method of inducing a T cell immune response, using such an immunogen. The invention further relates to nucleic acid sequences encoding the present immunogens.
    Type: Application
    Filed: September 17, 2004
    Publication date: August 2, 2007
    Inventors: Barton Haynes, Feng Gao, Bette Korber, Beatrice Hahn, George Shaw, Denise Kothe, Ying Ying Li, Julie Decker, Hua-Xin Liao