Abstract: A micro and nano-particulate drug comprising a drug substance and a surfactant in which the drug and surfactant form a eutectic mixture. The matrix formed between the drug substance and the surfactant has a melting point less than the decomposition temperature of the drug substance and thus provides the advantages of reduced irritation due to the melting process without the prior art problem of decomposition of the drug substance. In one embodiment, crystals are formed while the mixture is cooled at room temperature under high shear conditions. In a second embodiment, a flowable material may be formed which also contains the drug and that may be incorporated into a pharmaceutical delivery system is also disclosed. Methods of preparing the micro and nano-particulate drug crystals and non-crystalline substance are also contemplated in the inventive subject matter.

Abstract: The present inventive subject matter relates to amorphous drug beads comprising an amorphous active drug and an organic surfactant having improved solubility, absorption and wettability characteristics. The present inventive subject matter further relates to methods of preparing the amorphous drug beads, wherein molten drug beads are subject to a cooling step with or without shear.

Abstract: A micro and nano-particulate drug comprising a drug substance and a surfactant in which the drug and surfactant form a eutectic mixture. The matrix formed between the drug substance and the surfactant has a melting point less than the decomposition temperature of the drug substance and thus provides the advantages of reduced irritation due to the melting process without the prior art problem of decomposition of the drug substance. In one embodiment, crystals are formed while the mixture is cooled at room temperature under high shear conditions. In a second embodiment, a flowable material may be formed which also contains the drug and that may be incorporated into a pharmaceutical delivery system is also disclosed. Methods of preparing the micro and nano-particulate drug crystals and non-crystalline substance are also contemplated in the inventive subject matter.

Abstract: The present inventive subject matter relates to amorphous drug beads comprising an amorphous active drug and an organic surfactant having improved solubility, absorption and wettability characteristics. The present inventive subject matter further relates to methods of preparing the amorphous drug beads, wherein molten drug beads are subject to a cooling step with or without shear.

Abstract: The present invention provides a method and apparatus for forming a compression dosage unit such as a tablet. The method of the present invention includes dispensing a premeasured volume of tableting feedstock into a product tray. The feedstock is compacted into a tablet within the product tray. The product tray may be further packaged for distribution and sale. The apparatus of the present invention includes a dossiter for dispensing the premeasured volume of feedstock into the product tray from a reservoir. A die is insertable into the product tray to form the tablet therein. The present invention also provides for the formation of the tablets within the product tray by use of the dossiter.

Abstract: A method and apparatus provides for the formation of compression dosage units from tableting feedstock. A feedstock dossiter is provided including an open ended chamber for insertion into a reservoir containing the tableting feedstock. The dossiter includes a movable die punch which is movable within the chamber between at least two positions. A first position away from the open end of the chamber provides for the collection of a preselected volume of tableting feedstock from the reservoir. The die punch is movable to a second position which effects formation of the tablet within the accumulation chamber. The dossiter shown herein may be used in combination with a fixed die punch to form the tablet.

Abstract: A method and apparatus is provided for the formation of a tablet from tableting feedstock. An elongate die is provided which has a cavity defined by an inner wall. A pair of die punches are insertably positioned within the cavity. The die punches include opposed facing surfaces for supporting therebetween tableting feedstock. The die punches are relatively movable within the cavity to a tablet forming position to compress the feedstock into a tablet. The tablet forming positions defined by the facing die punch surfaces are spaced apart sufficient distance so as to maintain the formed tablet in contact with the inner wall of the cavity so as to retain the tablet within the cavity upon removal of the die punches.