Abstract: Systems and methods provide a network-accessible user interface that provides a user with tools for creating and managing laboratory signage. A user interacts with the interface in order to select pre-designed laboratory signage or to create custom laboratory signage. The user may select or create multiple laboratory signs, which may be associated with one or more laboratories or rooms. The user may subsequently retrieve one or more of the laboratory signs in order to print, electronically distribute, or edit, as desired. An interface permits the user to enter manually, import, select, calculate and/or create the desired text, graphics, and other information to be included on a laboratory sign and to select the desired layout for the sign from a menu of established templates.