Patents by Inventor Beverly D. Smolich

Beverly D. Smolich has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Novel biomarkers of tyrosine kinase inhibitor exposure and activity in mammals
    Publication number: 20040018528
    Abstract: The present invention describes novel methods that measure in a mammal the level of at least one biomarker, such as a protein and/or mRNA transcript. Based on the level of at least one biomarker in a mammal exposed to a test compound, compared to the level of the biomarker(s) in a mammal that has not been exposed to a test compound, the ability of the test compound to inhibit tyrosine kinase activity can be determined. The invention also relates to novel methods, wherein a change in the level of at least one biomarker in a mammal exposed to a compound, compared to the level of the biomarker(s) in a mammal that has not been exposed to the compound, indicates whether the mammal is being exposed to, or is experiencing or will experience a therapeutic or toxic effect in response to, a compound that inhibit tyrosine kinase activity.
    Type: Application
    Filed: May 19, 2003
    Publication date: January 29, 2004
    Applicant: Sugen, Inc.
    Inventors: Alyssa Morimoto, Samuel DePrimo, Anne-Marie O'Farrell, Beverly D. Smolich, William C. Manning, Sarah A. Walter, James W. Schilling, Julie Cherrington