Abstract: Therapeutical application of elevated or depressed temperatures to various afflicted portions of an animal or human body with a multilayered device combining protective and insulative means with heating and cooling means renders pain less acute, alleviates disease, reduces body temperature, stimulates circulatory and respiratory systems. The heating and cooling means features an array of non-communicating chambers enclosing packets containing a thermoresponsive mixture while the protective and insulative means features a layer of resilient material and a layer of fabric-backed covering material. The reusable therapeutic device of the present invention can be manufactured in various sizes and shapes to conform to the contours of any animal or human body area and if damaged, can be easily repaired or the damaged part can be easily replaced.