Patents by Inventor Bevin P. Engelward

Bevin P. Engelward has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR CELL PROLIFERATION AND TOXICITY TESTING
    Publication number: 20200109362
    Abstract: Provided herein are methods and devices for measuring and monitoring proliferation and toxicity in vitro.
    Type: Application
    Filed: June 21, 2017
    Publication date: April 9, 2020
    Applicant: Massachusetts Institute of Technology
    Inventors: Bevin P. Engelward, Le P. Ngo, Tze Khee Chan, Jing Ge
  • Devices and processes for analyzing nucleic acid damage and repair using electrophoresis
    Patent number: 9194841
    Abstract: Systems, methods, and devices are provided for assessing DNA damage and repair in cells by measuring DNA migration under electrophoresis. In one exemplary embodiment, a microarray configured to hold cells in a predetermined spatial relationship is employed to improve accuracy, speed, and reliability of such measurements. In another embodiment, a self-contained cassette having a matrix material disposed therein can be used to create a substantially uniform environment for analyzing DNA damage and repair. Fluid can be circulated through the cell to assist in creating spatial patterns on the matrix material, or alternatively, the matrix material can already include a microarray pattern disposed thereon. Various methods and systems that take advantage of such microarrays and cassettes are also provided.
    Type: Grant
    Filed: July 12, 2012
    Date of Patent: November 24, 2015
    Assignee: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Sangeeta N. Bhatia, Bevin P. Engelward, David K. Wood, David M. Weingeist
  • DEVICES AND PROCESSES FOR ANALYZING NUCLEIC ACID DAMAGE AND REPAIR USING ELECTROPHORESIS
    Publication number: 20120277118
    Abstract: Systems, methods, and devices are provided for assessing DNA damage and repair in cells by measuring DNA migration under electrophoresis. In one exemplary embodiment, a microarray configured to hold cells in a predetermined spatial relationship is employed to improve accuracy, speed, and reliability of such measurements. In another embodiment, a self-contained cassette having a matrix material disposed therein can be used to create a substantially uniform environment for analyzing DNA damage and repair. Fluid can be circulated through the cell to assist in creating spatial patterns on the matrix material, or alternatively, the matrix material can already include a microarray pattern disposed thereon. Various methods and systems that take advantage of such microarrays and cassettes are also provided.
    Type: Application
    Filed: July 12, 2012
    Publication date: November 1, 2012
    Applicant: Massachusetts Institute of Technology
    Inventors: Sangeeta N. Bhatia, Bevin P. Engelward, David K. Wood, David M. Weingeist
  • DEVICES AND PROCESSES FOR ANALYZING NUCLEIC ACID DAMAGE AND REPAIR USING ELECTROPHORESIS
    Publication number: 20090272657
    Abstract: Systems, methods, and devices are provided for assessing DNA damage and repair in cells by measuring DNA migration under electrophoresis. In one exemplary embodiment, a microarray configured to hold cells in a predetermined spatial relationship is employed to improve accuracy, speed, and reliability of such measurements. In another embodiment, a self-contained cassette having a matrix material disposed therein can be used to create a substantially uniform environment for analyzing DNA damage and repair. Fluid can be circulated through the cell to assist in creating spatial patterns on the matrix material, or alternatively, the matrix material can already include a microarray pattern disposed thereon. Various methods and systems that take advantage of such microarrays and cassettes are also provided.
    Type: Application
    Filed: April 28, 2009
    Publication date: November 5, 2009
    Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Sangeeta N. Bhatia, Bevin P. Engelward, David K. Wood, David M. Weingeist