Patents by Inventor Bevyn Jarrott
Bevyn Jarrott has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10577308Abstract: The present disclosure relates generally to compounds having activity as voltage-gated sodium channel blockers and their use in the field of therapeutic treatment, including the therapy or management of conditions associated with excessive, unwanted, inadequate or otherwise undesirable sodium ion passage through cellular membranes via voltage-gated sodium channels. In some embodiments, the disclosure relates to aryloxy-substituted amines for use as sodium channel blockers or modulators. Methods for their manufacture and compositions containing the compounds are also disclosed.Type: GrantFiled: March 24, 2016Date of Patent: March 3, 2020Assignees: The Florey Institute, The University of MelbourneInventors: Spencer John Williams, Bevyn Jarrott
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Publication number: 20140323527Abstract: The present invention relates generally to the field of therapeutic treatment and compounds having utility therefor, in particular the therapy or management of conditions associated with excessive, unwanted or undesirable sodium ion passage through cellular membranes via voltage-gated sodium channels. In one embodiment the invention is concerned with the treatment of neuropathic pain. The invention contemplates to aryloxy-substituted amines, as sodium channel blockers or modulators. In further embodiments, the invention also relates to compounds which may advantageously have dual sodium channel blocker/modulating and antioxidative (free-radical scavenging) effects. Methods for their manufacture and compositions containing the compounds are also contemplated.Type: ApplicationFiled: March 24, 2014Publication date: October 30, 2014Applicant: HOWARD FLOREY INSTITUTEInventor: Bevyn JARROTT
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Patent number: 8716528Abstract: The present invention relates generally to the field of therapeutic treatment and compounds having utility therefor, in particular the therapy or management of conditions associated with excessive, unwanted or undesirable sodium ion passage through cellular membranes via voltage-gated sodium channels. In one embodiment the invention is concerned with the treatment of neuropathic pain. The invention contemplates to aryloxy-substituted amines, as sodium channel blockers or modulators. In further embodiments, the invention also relates to compounds which may advantageously have dual sodium channel blocker/modulating and antioxidative (free-radical scavenging) effects. Methods for their manufacture and compositions containing the compounds are also contemplated.Type: GrantFiled: October 31, 2008Date of Patent: May 6, 2014Assignee: Howard Florey InstituteInventor: Bevyn Jarrott
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Patent number: 8017649Abstract: Novel flavonoid compounds having anti-oxidant activity are described. The compounds and compositions have been shown to exhibit anti-oxidant properties and are particularly useful in the treatment of ischemia and reperfusion injuries. The invention also describes a method to chemically synthesize such flavonoid compounds and test their efficacy. Such compounds and corresponding pharmaceutically acceptable derivatives and/or salts have uses in the areas of pharmaceuticals, nutraceutical, and veterinary applications.Type: GrantFiled: March 10, 2006Date of Patent: September 13, 2011Assignee: Howard Florey Institute of Experimental Physiology and MedicineInventors: Bevyn Jarrott, Clive Newton May, Owen Llewellyn Woodman, Gregory James Dusting
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Publication number: 20110021577Abstract: The present invention relates generally to the field of therapeutic treatment and compounds having utility therefor, in particular the therapy or management of conditions associated with excessive, unwanted or undesirable sodium ion passage through cellular membranes via voltage-gated sodium channels. In one embodiment the invention is concerned with the treatment of neuropathic pain. The invention contemplates to aryloxy-substituted amines, as sodium channel blockers or modulators. In further embodiments, the invention also relates to compounds which may advantageously have dual sodium channel blocker/modulating and antioxidative (free-radical scavenging) effects. Methods for their manufacture and compositions containing the compounds are also contemplated.Type: ApplicationFiled: October 31, 2008Publication date: January 27, 2011Applicant: HOWARD FLOREY INSTITUTEInventor: Bevyn Jarrott
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Publication number: 20090130051Abstract: Novel flavonoid compounds having anti-oxidant activity are described. The compounds and compositions have been shown to exhibit anti-oxidant properties and are particularly useful in the treatment of ischemia and reperfusion injuries. The invention also describes a method to chemically synthesize such flavonoid compounds and test their efficacy. Such compounds and corresponding pharmaceutically acceptable derivatives and/or salts have uses in the areas of pharmaceuticals, nutraceutical, and veterinary applications.Type: ApplicationFiled: March 10, 2006Publication date: May 21, 2009Applicants: Howard Florey Institute Of Experimental Physiology And Medicine, Neuprotect Pty LtdInventors: Bevyn Jarrott, Clive Newton May, Owen Llewellyn Woodman, Gregory James Dusting
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Publication number: 20050159437Abstract: This invention relates to compounds of formula (1) wherein B is optionally substituted aryl; R1 and R2 are the same or different and are independently selected from hydrogen or C1-3 alkyl; n is 1 or 2, preferably n is 1; m is 0 or 1; R3 is hydrogen or acyl; R4 and R5 are the same or different and are independently selected from amino, alkylamino, dialkylamino, arylamino and C2-C8 cycloalkylamino; X and Y are independently selected from C, H or N provided at least one of X and Y is N; and salts thereof, solvates thereof, pharmaceutically acceptable derivatives thereof, prodrugs thereof, tautomers thereof and/or isomers thereof; and processes for their preparation and methods of treatment, pharmaceutical formulations and uses involving them.Type: ApplicationFiled: February 2, 2005Publication date: July 21, 2005Inventors: Bevyn Jarrott, Phillip Beart, William Jackson, Alan Robertson, Maree Collis, Alexandra Papanikos
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Patent number: 6881740Abstract: This invention relates to compounds to formula (1) wherein B is optionally substituted aryl; R1 and R2 are the same or different and are independently selected from hydrogen or C1-3 alkyl; n is 1 or 2, preferably n is 1; m is 0 or 1; R3 is hydrogen or acyl, R4 and R5 are the same or different and are independently selected from amino, alkylamino, dialkylamino, arylamino and C2-C4 cycloalkylamino; X and Y are independently selected from C, H or N provided at least one of X and Y is N; and salts thereof, solvates thereof, pharmaceutically acceptable derivatives thereof, prodrugs thereof, tautomers thereof and/or isomers thereof, and processes for their reparation and methods of treatment, pharmaceutical formulations and uses involving them.Type: GrantFiled: July 8, 1999Date of Patent: April 19, 2005Assignee: Monash UniversityInventors: Bevyn Jarrott, Phillip Mark Beart, William Roy Jackson, Alan Duncan Robertson, Maree Patricia Collis, Alexandra Papanikos
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Patent number: 6232314Abstract: Arylalkylpiperazine compounds (1) wherein B is aryl or optionally substituted aryl; R1 is hydroxy; R2 and R3 are the same or different and are independently selected from hydrogen or C1-3 alkyl; m is 0, 1 or 2; D is a linking chain of atoms which may be optionally substituted and which contains from 1 to 8 atoms in the chain; E is a phenolic antioxidant group or a corresponding amino derivative thereof wherein the phenolic hydroxyl is replaced by amino, are disclosed. The compounds have both free radical scavenging activity and block excitatory amino acid activity. Some compounds of the present invention also display an affinity for voltage-sensitive sodium channels.Type: GrantFiled: March 18, 1999Date of Patent: May 15, 2001Assignee: Monash UniversityInventors: Bevyn Jarrott, Philip Mark Beart, William Roy Jackson, Vijaya Bhaskar Kenche, Alan Duncan Robertson, Maree Patricia Collis
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Patent number: 5462965Abstract: A class of heterocyclic amino-alcohol compounds is described for treatment of CNS-related diseases, namely, for use as a neuroprotective agent, to reduce neurotoxic injury associated with conditions of hypoxia, anoxia or ischemia which typically follows stroke, myocardial infarct, perinatal asphyxia, or hypoglycemic events. Other examples of treatable CNS-related diseases include neurodegenerative diseases such as Parkinson's disease, Huntington's chorea and Alzheimer's disease, and also psychotic disorders such as schizophrenia. The treatment includes administration of a compound of this class alone or in a composition in an amount effective as a mediator to alter excitatory actions at the NMDA excitatory amino acid receptor complex.Type: GrantFiled: December 7, 1992Date of Patent: October 31, 1995Assignee: GD Searle & Co.Inventors: Joseph L. Roba, Claude L. Gillet, Michael F. Rafferty, Bevyn Jarrott, Philip M. Beart
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Patent number: 4094964Abstract: A sensitive immunoassay for clonidine, 2-(2,6-dichloroanilino)-2-imidazoline hydrochloride is described. To prepare the clonidine selective antiserum, an antigen is made comprising 4-[[6-[2,4-dichloro-3(4,5-dihydro-1H-imidazol-2-yl)amino]hydroxyphenyl]azo ]benzoic acid covalently bonded to an immunogenic carrier material through a peptide bond formed from said carboxyl group and amino groups contained in said immunogenic carrier material and the antigen is injected into a suitable host animal to elicit the desired antiserum.Type: GrantFiled: May 10, 1977Date of Patent: June 13, 1978Assignee: Hoffmann-La Roche Inc.Inventors: Bevyn Jarrott, Sidney Spector