Abstract: A topical composition for treating an inflammatory skin disease in a subject includes a therapeutically effective amount of a biguanidine, and is in a dosage form for topical administration. A method for treating an inflammatory skin disease in a subject includes the following steps: identifying a subject in need thereof; providing a biguanidine; and administering the biguanidine in a therapeutically effective amount to a part of the subject to treat the inflammatory skin disease.

Abstract: A therapeutic intervention guidance system for atopic eczema includes a device measuring a skin surface moisture level and a Trans-Epidermal Water Loss (TEWL) value of a subject, a process comparing the skin surface moisture level and the TEWL value with a predetermined level and value, and an outcome providing a therapeutic intervention guidance based on the comparison. A method of providing therapeutic intervention guidance for atopic eczema includes measuring a skin surface moisture level and a Trans-Epidermal Water Loss (TEWL) value of a subject, comparing the skin surface moisture level and the TEWL value with a predetermined level and value, and providing a therapeutic intervention guidance based on the comparison.