Patents by Inventor Bhagyashree Bhagwat

Bhagyashree Bhagwat has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CELL BASED ASSAY TO MEASURE THE T-CELL STIMULATING CAPACITY OF ANTI-LAG3 ANTIBODIES AND OTHER AGENTS
    Publication number: 20170097333
    Abstract: The present invention includes a human LAG3 functional assay using a Jurkat T-cell lymphoma cell line engineered to overexpress LAG3 at an optimal level relative to CD3. The assay is useful, for example, for determining the immunostimulatory properties of LAG3 modulators (e.g., inhibitors or activators). The optimized LAG3/CD3 ratio ensures expression of optimal receptor components on the T-cell and, thus, superior assay sensitivity. Immunostimulation of the T-cells can be measured, for example, by following cytokine (e.g., IL-2) production. The optimized T-cell line forms part of the present invention along with compositions generated with use of the assay.
    Type: Application
    Filed: September 28, 2016
    Publication date: April 6, 2017
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Bhagyashree Bhagwat, Aarron Willingham