Abstract: Present invention teaches an improved method of treating cancer comprising intravenously administering to a subject in need thereof substantially ethanol free nanoparticles comprising an anticancer drug and a substantially hydroxyl free unsaturated edible oil saturated at least at one site of unsaturation by a covalently attached hydrogen atom and a covalently attached water soluble polymer.

Abstract: An aqueous enzyme based sensor comprising one or more enzymes and at least one indicator compound capable of indicating a reaction of at least one of the enzymes with at least one target analyte, wherein the enzyme and the indicator are capable of being delivered, preferably by being sprayed, to a surface having the target analyte without sampling the surface. An aqueous enzyme based sensor is provided that is capable of detecting an enzyme specific substrate as the analyte. This aqueous enzyme based sensor further comprises of one or more enzyme specific substrates in which the sensor detects enzyme inhibition. The aqueous enzyme based sensor optionally comprises one or more of a light scattering additive(s), an adhesive polymer(s), a protein stabilizer(s), a protein stabilizing sugar(s), a surfactant(s), and a solvent(s), and combinations thereof. A dispensing system and a method of detecting a target chemical on a surface without sampling the surface is provided.

Abstract: Present invention relates to surfactants derived from epoxidized oils and compositions thereof. Particularly this invention describes surfactants derived from epoxidized oils covalently attached to water soluble polymers via thioether bond forming linker and formulations thereof.

Abstract: This invention relates to polyhydric compounds containing primary and secondary hydroxyl groups selectively conjugated with linkers, polymers, and/or bioactive agents.

Abstract: A method of synthesizing a protein-polymer conjugate includes the steps: covalently attaching at least one controlled radical polymerization initiator to a protein to form a protein-initiator composition; and mixing the protein-initiator composition with at least one monomer which undergoes controlled radical polymerization in the presence of the protein-initiator composition under conditions suitable to initiate the controlled radical polymerization.

Abstract: An aqueous enzyme based sensor comprising one or more enzymes and at least one indicator compound capable of indicating a reaction of at least one of the enzymes with at least one target analyte, wherein the enzyme and the indicator are capable of being delivered, preferably by being sprayed, to a surface having the target analyte without sampling the surface. An aqueous enzyme based sensor is provided that is capable of detecting an enzyme specific substrate as the analyte. This aqueous enzyme based sensor further comprises of one or more enzyme specific substrates in which the sensor detects enzyme inhibition. The aqueous enzyme based sensor optionally comprises one or more of a light scattering additive(s), an adhesive polymer(s), a protein stabilizer(s), a protein stabilizing sugar(s), a surfactant(s), and a solvent(s), and combinations thereof. A dispensing system and a method of detecting a target chemical on a surface without sampling the surface is provided.

Abstract: The present invention provides novel thermoprecipitating polymers of formula 1 containing novel enzyme sensitive ligands of the formula 4, processes for the preparation thereof respectively, and to the use thereof for the separation of enzymes. In formula 1 R is hydrogen or methyl, 1 is an integer in the range of from 1 to 10, m and n are either 0 or 1, x and y are integers greater than 1.

Abstract: This invention relates to novel amphiphilic diblock, triblock copolymers and star-shaped block copolymers comprising a biodegradable polymer covalently attached at the polymer ends, to a hydrophilic vinyl polymer, via divalent sulfur atom; to a process for producing the block polymers; to a polymerization process which comprises subjecting the monomers capable of radical polymerization to radical polymerization in the presence of a macromolecular biodegradable chain-transfer agent; and to pharmaceutical compositions comprising the block copolymers loaded with therapeutic agents.

Abstract: The present invention provides novel thermoprecipitating polymers of formula 1 containing novel enzyme sensitive ligands of the formula 4, processes for the preparation thereof respectively, and to the use thereof for the separation of enzymes.

Abstract: The present invention relates to a process for the preparation of thermoprecipitating affinity polymers useful in the enhanced recovery of enzymes. The process comprises polymerising a monomer comprising a spacer and a co-monomer with a polymerisation initiator and a polymerisation accelerator at ambient temperature and pressure for a period ranging between 2 to 24 hours to obtain a polymer and then linking an inhibitor to pendant carboxyl groups of the spacers in the polymer to obtain an affinity polymer.

Abstract: This invention relates to novel amphiphilic diblock, triblock copolymers and star-shaped block copolymers comprising a biodegradable polymer covalently attached at the polymer ends, to a hydrophilic vinyl polymer, via divalent sulfur atom; to a process for producing the block polymers; to a polymerization process which comprises subjecting the monomers capable of radical polymerization to radical polymerization in the presence of a macromolecular biodegradable chain-transfer agent; and to pharmaceutical compositions comprising the block copolymers loaded with therapeutic agents.

Abstract: The present invention provides novel thermoprecipitating polymers of formula 1, processes for the preparation thereof respectively and to the use thereof for the separation of enzymes. In formula 1 R is hydrogen or methyl, and x and y are integers greater than 1.

Abstract: The present invention provides novel thermoprecipitating polymers of formula 1 containing novel enzyme sensitive ligands of the formula 4, processes for the preparation thereof respectively, and to the use thereof for the separation of enzymes. In formula 1 R is hydrogen or methyl, 1 is an integer in the range of from 1 to 10, m and n are either 0 or 1, x and y are integers greater than 1.

Abstract: The present invention relates to a process for the preparation of thermoprecipitating affinity polymers useful in the enhanced recovery of enzymes. The process comprises polymerising a monomer comprising a spacer and a co-monomer with a polymerisation initiator and a polymerisation accelerator at ambient temperature and pressure for a period ranging between 2 to 24 hours to obtain a polymer and then linking an inhibitor to pendant carboxyl groups of the spacers in the polymer to obtain an affinity polymer.

Abstract: The present invention provides novel thermoprecipitating polymers of formula 1 containing novel enzyme sensitive ligands of the formula 4, processes for the preparation thereof respectively, and to the use thereof for the separation of enzymes. In formula 1 R is hydrogen or methyl, 1 is an integer in the range of from 1 to 10, m and n are either 0 or 1, x and y are integers greater than 1.

Abstract: The present invention relates to a process for the preparation, of thermoprecipitating affinity polymers useful in the enhanced recovery of enzymes. The process comprises polymerising a monomer comprising a spacer and a co-monomer with a polymerisation initiator and a polymerisation accelerator at ambient temperature and pressure for a period ranging between 2 to 24 hours to obtain a polymer and then linking an inhibitor to pendant carboxyl groups of the spacers in the polymer to obtain an affinity polymer.

Abstract: The invention relates to a process for the preparation of molecularly imprinted polymers useful for separation of enzymes, which comprises the steps of reacting a complex of enzyme and affinity monomer, a comonomer and a crosslinker, with a polymerization initiator and a polymerization accelerator at ambient temperature and pressure for a period ranging between 2 to 24 hrs, thereby obtaining a crosslinked polymer, crushing the cross linked polymer obtained to fine particles, adding a solvent and extracting imprinted enzyme from the polymer, obtaining the molecularly imprinted polymer, contacting the imprinted polymer with aqueous solution containing imprinted enzyme or a mixture of imprinted enzyme and other enzymes and isolating the enzyme-adsorbed polymer.

Abstract: The present invention relates to a process for the preparation of N-substituted acrylamides of the general formula CH2═CH—CONHR, wherein, R is alkyl group having carbon 1 to 22 or acyl group having carbon 1 to 18. The process for the preparation of the N-substituted acrylamides comprises reacting acrylamide with alkyl acyl chloride in the presence of Lewis acid catalyst in an organic solvent at a temperature ranging between room temperature to 50° C. for a period ranging between 1 hour to 24 hours.

Abstract: The present invention relates to a process for the preparation of diesters of poly (ethylene glycol) by reacting poly (oxyalkylene glycol) and amino acid hydrochloride in the presence of a condensing agent in a suitable solvent at a temperature in the range of 0° C. to room temperature for a period ranging between 1 hour to 24 hours. The reaction mixture is then filtered and the filtrate poured into another solvent, which is a nonsolvent for the products. The products precipitated thereby are then isolated.

Abstract: The present invention relates to the preparation of enzymatically degradable polymers, having repeating structural unit as shown hereinbelow: X—is selected from phenolic —OH of tyrosine, —OH of serine and threonine and —SH of cysteine Y—is pendant group selected from drug molecules containing carboxyl groups, R—is hydrogen, methyl or mixture of hydrogen and methyl on the individual molecule, n—is an integer from 0 to about 100, and m—is an integer from 0 to 10, the said process comprises the steps of reacting diester of poly (oxyalkylene glycol) and hydrochloride of trifunctional amino acid with a dicarboxylic acid in the presence of a condensing agent in a solvent at a temperature in the range of 0° C.