Abstract: In a method of registering three-dimensional brain images, a reference slice for a midsagittal plane of each image is constructed. The reference slice comprises image points forming a cortical edge. Edge points are selected from these image points such that an ellipse fit to the edge points approximates the cortical edge. The reference ellipse in each image that fits the edge points is determined. The images are registered in a same coordinate system such that the reference ellipses in the images are aligned with one another.

Abstract: Methods (2900), apparatuses (3000), and computer program products for segmenting an infarct in a diffusion-weighted imaging (DWI) volume are disclosed. A Region of Interest in at least one slice of the DWI volume is selected (2912). The ROI comprises at least a portion of the slice. A threshold for a minimum size of an infarct region is selected (2916). An energy mask is convolved (2918) with that slice, and the resulting energy image is normalized (2920). The ROI in the convolved energy image is selected (2922). An initial threshold is determined (2924) using a histogram of the ROI of the slice without a background region, and an initial segmentation of the slice is performed (2926). Individual components of the initial segmentation of the slice are labeled (2930). A final threshold is determined (2932) using histograms of labeled components if the initial segmentation, and a final segmentation if the slice is performed (2934) using that threshold.

Abstract: Volumes of interest may be defined, within a three-dimensional brain image, for each of three orthogonal directions. Measures, which may, for example, be energy or entropy measures, are determined for slices of the volumes of interest in the three directions. The volume of interest corresponding to the sagittal direction is then identified. The slice, among the slices in the volume of interest corresponding to the identified sagittal direction, having the optical measure is used to define a first estimate of the mid-sagittal plane. The first estimate of the mid-sagittal plane may then be used to build an input to an optimization technique, which operates until a convergence criterion is satisfied, at which point a final estimate of the mid-sagittal plane may be produced.

Abstract: Methods (2900), apparatuses (3000), and computer program products for segmenting an infarct in a diffusion-weighted imaging (DWI) volume are disclosed. A Region of Interest in at least one slice of the DWI volume is selected (2912). The ROI comprises at least a portion of the slice. A threshold for a minimum size of an infarct region is selected (2916). An energy mask is convolved (2918) with that slice, and the resulting energy image is normalized (2920). The ROI in the convolved energy image is selected (2922). An initial threshold is determined (2924) using a histogram of the ROI of the slice without a background region, and an initial segmentation of the slice is performed (2926). Individual components of the initial segmentation of the slice are labeled (2930). A final threshold is determined (2932) using histograms of labeled components if the initial segmentation, and a final segmentation if the slice is performed (2934) using that threshold.

Abstract: In a method of registering three-dimensional brain images, a reference slice for a midsagittal plane of each image is constructed. The reference slice comprises image points forming a cortical edge. Edge points are selected from these image points such that an ellipse fit to the edge points approximates the cortical edge. The reference ellipse in each image that fits the edge points is determined. The images are registered in a same coordinate system such that the reference ellipses in the images are aligned with one another.

Abstract: The present invention discloses a method for registering a measured MRI volume image with appropriate anatomical and blood supply territory Atlases to enable Atlas information to be mapped onto the measured MRI volume image. The disclosed arrangements provide an efficient method for mapping brain Atlas information (including gross anatomy and blood supply territories) into magnetic resonance perfusion and diffusion images.