Patents by Inventor Bharadwaj Jagannathan

Bharadwaj Jagannathan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pharmaceutical composition comprising bispecific antibody constructs for improved storage and administration
    Patent number: 11918650
    Abstract: The present invention provides an improved pharmaceutical composition for storage and administration comprising (a) a bispecific antibody construct comprising a first domain binding to a target cell surface antigen and a second domain binding to a second antigen, wherein the bispecific antibody construct is present at a concentration in the range from about 0.5 ?g/ml to 20 mg/ml, (b) a preservative at a concentration effective to inhibit the growth of microbes, and (c) a diluent wherein bispecific antibody construct is stable and recoverable.
    Type: Grant
    Filed: May 7, 2018
    Date of Patent: March 5, 2024
    Assignee: AMGEN INC.
    Inventors: Jeff Abel, Lingwen Cui, Devrishi Goswami, Joon Huh, Bharadwaj Jagannathan, Sekhar Kanapuram, Arnold McAuley, Michael Schneider, Ananthakrishnan G. Sethuraman, Michael Treuheit, Jun Zhang
  • PHARMACEUTICAL FORMULATION
    Publication number: 20230348596
    Abstract: The disclosure provides a formulation comprising, e.g., a bispecific antibody construct, a buffer, a saccharide, a surfactant, and methionine.
    Type: Application
    Filed: August 23, 2021
    Publication date: November 2, 2023
    Inventor: Bharadwaj Jagannathan
  • METHOD OF MAKING LYOPHILIZED PROTEIN FORMULATIONS
    Publication number: 20230310324
    Abstract: Disclosed herein are methods of preparing lyophilized formulations comprising a protein, such as an antibody or a bispecific antibody construct, that exhibits improved storage stability.
    Type: Application
    Filed: September 14, 2021
    Publication date: October 5, 2023
    Inventors: Arnold McAuley, Michael J. Treuheit, Twinkle R. Christian, Bharadwaj Jagannathan
  • PHARMACEUTICAL FORMULATION
    Publication number: 20230167175
    Abstract: The present disclosure describes stable aqueous formulations comprising, e.g., a bispecific antibody construct, a buffer, a saccharide and a surfactant, the formulation having a pH 4.8-5.5.
    Type: Application
    Filed: April 28, 2021
    Publication date: June 1, 2023
    Inventors: Twinkle R. Christian, Bharadwaj Jagannathan, Andrew Dykstra
  • PHARMACEUTICAL FORMULATION
    Publication number: 20230167176
    Abstract: Described herein are stable high concentration bispecific antibody construct formulations, wherein the formulations have less than 2% high molecular weight species of the bispecific antibody construct in the formulation under storage conditions at various time points.
    Type: Application
    Filed: April 28, 2021
    Publication date: June 1, 2023
    Applicant: AMGEN INC.
    Inventors: Twinkle R. Christian, Bharadwaj Jagannathan
  • SYSTEMS AND APPROACHES FOR DRUG DELIVERY
    Publication number: 20220362104
    Abstract: An approach for determining material compatibility for components of a drug delivery system is provided that includes using surface zeta-potential analytical method to evaluate surface interactions between a desired molecule and at least one material present within a given IV-bag system.
    Type: Application
    Filed: October 23, 2020
    Publication date: November 17, 2022
    Inventors: Cornelius Pompe, Nicholas J. Clark, Wei Qi, Arnold J. McAuley, MIchael Schneider, Chia-Jung Wu, Twinkle R. Christian, Heather N. Franey, Bharadwaj Jagannathan, Jeffrey Abel, Franz Dietzel
  • PHARMACEUTICAL FORMULATIONS OF MASKED ANTIBODIES
    Publication number: 20210236636
    Abstract: The present disclosure is directed to low pH pharmaceutical compositions and/or formulations comprising a masked antigen binding protein.
    Type: Application
    Filed: July 30, 2019
    Publication date: August 5, 2021
    Inventors: Michael John TREUHEIT, Pavan GHATTYVENKATAKRISHNA, Bharadwaj JAGANNATHAN
  • LOW PH PHARMACEUTICAL COMPOSITION COMPRISING T CELL ENGAGING ANTIBODY CONSTRUCTS
    Publication number: 20200332000
    Abstract: The present disclosure provides a low pH pharmaceutical composition comprising (a) an antibody constructs comprising a first domain binding to a target cell surface antigen, a second domain binding to a second antigen and preferably a third domain, which is a specific Fc modality, (b) at least one buffer agent, (c) at least one saccharide, and (d) at least one surfactant; and wherein the pH of the pharmaceutical composition is in the range of 3.5 to 6.
    Type: Application
    Filed: February 2, 2018
    Publication date: October 22, 2020
    Inventors: Arnold Mcauley, Pavan Ghattyvenkatakrishna, Jeff Abel, Joon Huh, Cornelius Pompe, Sekhar Kanapuram, Michael Treuheit, Bharadwaj Jagannathan
  • PHARMACEUTICAL COMPOSITION COMPRISING BISPECIFIC ANTIBODY CONSTRUCTS FOR IMPROVED STORAGE AND ADMINISTRATION
    Publication number: 20190151448
    Abstract: The present invention provides an improved pharmaceutical composition for storage and administration comprising (a) a bispecific antibody construct comprising a first domain binding to a target cell surface antigen and a second domain binding to a second antigen, wherein the bispecific antibody construct is present at a concentration in the range from about 0.5 ?g/ml to 20 mg/ml, (b) a preservative at a concentration effective to inhibit the growth of microbes, and (c) a diluent wherein bispecific antibody construct is stable and recoverable.
    Type: Application
    Filed: May 7, 2018
    Publication date: May 23, 2019
    Inventors: Jeff Abel, Lingwen Cui, Devrishi Goswami, Joon Huh, Bharadwaj Jagannathan, Sekhar Kanapuram, Arnold McAuley, Michael Schneider, Ananthakrishnan G. Sethuraman, Michael Treuheit, Jun Zhang