Patents by Inventor Bharat Aggarwal

Bharat Aggarwal has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synergistic effects of nuclear transcription factor NF-kappaB inhibitors and anti-neoplastic agents
    Publication number: 20040002499
    Abstract: The present invention provides methods of inhibiting metastasis of a tumor and methods of treating a tumor using a combination of an inhibitor of the activation of nuclear factor NF-&kgr;B and a cancer chemotherapeutic agent. In one embodiment of the present invention, combination of curcumin and paclitaxel (taxol) can be used to treat and inhibit metastasis of breast tumor.
    Type: Application
    Filed: April 24, 2003
    Publication date: January 1, 2004
    Inventor: Bharat Aggarwal
  • Inhibitors of receptor activator of NF-kappaB and uses thereof
    Publication number: 20030013170
    Abstract: The present invention provides a RANK (receptor activator of NF-&kgr;B) inhibitor consisted of a TRAF-6 (TNF receptor-associated factor-6) binding domain attached to a leader sequence. The peptide inhibitor inhibits RANKL (RANK ligand)-mediated osteoclast differentiation, thus indicating that targeted disruption of interaction between RANK and TRAF6 may prove useful as a therapeutic for metabolic bone disorders, leukemia, arthritis, and metastatic cancer of the bone.
    Type: Application
    Filed: May 10, 2002
    Publication date: January 16, 2003
    Inventors: Bharat Aggarwal, Bryant G. Darnay, Sujay Singh
  • Protein sequence of the plant toxin gelonin
    Patent number: 5631348
    Abstract: This invention relates to substantially purified gelonin, toxic fragments thereof, the DNA sequences encoding gelonin and use of the DNA for producing, by recombinant technology, gelonin, toxic fragments thereof and fusion proteins. More specifically, the invention relates to the primary amino acid sequence of gelonin, and of the DNA encoding said gelonin and the production of synthetic gelonin and toxic fragments thereof.
    Type: Grant
    Filed: June 6, 1994
    Date of Patent: May 20, 1997
    Assignee: The Research Development Foundation
    Inventors: Michael Rosenblum, William J. Kohr, Bharat Aggarwal
  • Protein sequence of the plant toxin gelonin
    Patent number: RE37462
    Abstract: This invention relates to substantially purified gelonin, toxic fragments thereof, the DNA sequences encoding gelonin and use of the DNA for producing, by recombinant technology, gelonin, toxic fragments thereof and fusion proteins. More specifically, the invention relates to the primary amino acid sequence of gelonin, and of the DNA encoding said gelonin and the production of synthetic gelonin and toxic fragments thereof.
    Type: Grant
    Filed: May 20, 1999
    Date of Patent: December 4, 2001
    Assignee: The Research Development Foundation
    Inventors: Michael Rosenblum, William J. Kohr, Bharat Aggarwal