Patents by Inventor Bharat ANNALDAS
Bharat ANNALDAS has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240064400Abstract: Real-time focusing in a slide-scanning system. In an embodiment, focus points are added to 500 an initialized focus map while acquiring a plurality of image stripes of a sample on a glass slide. For each image stripe, a plurality of frames, collectively representing the image stripe, may be acquired using both an imaging line-scan camera and a tilted focusing line-scan camera. Focus points, representing positions of best focus for trusted frames, are added to the focus map. Outlying focus points are removed from the focus map. In some cases, one or more image stripes may be reacquired. Finally, the image stripes are assembled into a composite image of the sample.Type: ApplicationFiled: November 2, 2023Publication date: February 22, 2024Inventors: Allen H. OLSON, Yunlu ZOU, Bharat ANNALDAS, Leng-Chun CHEN
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Patent number: 11863867Abstract: Real-time focusing in a slide-scanning system. In an embodiment, focus points are added to an initialized focus map while acquiring a plurality of image stripes of a sample on a glass slide. For each image stripe, a plurality of frames, collectively representing the image stripe, may be acquired using both an imaging line-scan camera and a tilted focusing line-scan camera. Focus points, representing positions of best focus for trusted frames, are added to the focus map. Outlying focus points are removed from the focus map. In some cases, one or more image stripes may be reacquired. Finally, the image stripes are assembled into a composite image of the sample.Type: GrantFiled: August 5, 2020Date of Patent: January 2, 2024Inventors: Allen H. Olson, Yunlu Zou, Bharat Annaldas, Leng-Chun Chen
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Patent number: 11449998Abstract: A convolutional neural network (CNN) is applied to identifying tumors in a histological image. The CNN has one channel assigned to each of a plurality of tissue classes that are to be identified, there being at least one class for each of non-tumorous and tumorous tissue types. Multi-stage convolution is performed on image patches extracted from the histological image followed by multi-stage transpose convolution to recover a layer matched in size to the input image patch. The output image patch thus has a one-to-one pixel-to-pixel correspondence with the input image patch such that each pixel in the output image patch has assigned to it one of the multiple available classes. The output image patches are then assembled into a probability map that can be co-rendered with the histological image either alongside it or over it as an overlay. The probability map can then be stored linked to the histological image.Type: GrantFiled: August 6, 2020Date of Patent: September 20, 2022Assignee: Leica Biosystems Imaging, Inc.Inventors: Walter Georgescu, Allen Olson, Bharat Annaldas, Darragh Lawler, Kevin Shields, Kiran Saligrama, Mark Gregson
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Patent number: 11403861Abstract: Automated stain finding. In an embodiment, an image of a sample comprising one or more stains is received. For each of a plurality of pixels in the image, an optical density vector for the pixel is determined. The optical density vector comprises a value for each of the one or more stains, and represents a point in an optical density space that has a number of dimensions equal to a number of the one or more stains. The optical density vectors are transformed from the optical density space into a representation in a lower dimensional space. The lower dimensional space has a number of dimensions equal to one less than the number of dimensions of the optical density space. An optical density vector corresponding to each of the one or more stains is identified based on the representation.Type: GrantFiled: September 16, 2016Date of Patent: August 2, 2022Assignee: LEICA BIOSYSTEMS IMAGING, INC.Inventors: Walter Georgescu, Bharat Annaldas, Allen Olson, Kiran Saligrama
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Publication number: 20220159171Abstract: Real-time focusing in a slide-scanning system. In an embodiment, focus points are added to an initialized focus map while acquiring a plurality of image stripes of a sample on a glass slide. For each image stripe, a plurality of frames, collectively representing the image stripe, may be acquired using both an imaging line-scan camera and a tilted focusing line-scan camera. Focus points, representing positions of best focus for trusted frames, are added to the focus map. Outlying focus points are removed from the focus map. In some cases, one or more image stripes may be reacquired. Finally, the image stripes are assembled into a composite image of the sample.Type: ApplicationFiled: August 5, 2020Publication date: May 19, 2022Inventors: Allen H. Olson, Yunlu Zou, Bharat Annaldas, Leng-Chun Chen
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Publication number: 20200364867Abstract: A convolutional neural network (CNN) is applied to identifying tumors in a histological image. The CNN has one channel assigned to each of a plurality of tissue classes that are to be identified, there being at least one class for each of non-tumorous and tumorous tissue types. Multi-stage convolution is performed on image patches extracted from the histological image followed by multi-stage transpose convolution to recover a layer matched in size to the input image patch. The output image patch thus has a one-to-one pixel-to-pixel correspondence with the input image patch such that each pixel in the output image patch has assigned to it one of the multiple available classes. The output image patches are then assembled into a probability map that can be co-rendered with the histological image either alongside it or over it as an overlay. The probability map can then be stored linked to the histological image.Type: ApplicationFiled: August 6, 2020Publication date: November 19, 2020Inventors: Walter GEORGESCU, Allen OLSON, Bharat ANNALDAS, Darragh LAWLER, Kevin SHIELDS, Kiran SALIGRAMA, Mark GREGSON
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Patent number: 10740896Abstract: A convolutional neural network (CNN) is applied to identifying tumors in a histological image. The CNN has one channel assigned to each of a plurality of tissue classes that are to be identified, there being at least one class for each of non-tumorous and tumorous tissue types. Multi-stage convolution is performed on image patches extracted from the histological image followed by multi-stage transpose convolution to recover a layer matched in size to the input image patch. The output image patch thus has a one-to-one pixel-to-pixel correspondence with the input image patch such that each pixel in the output image patch has assigned to it one of the multiple available classes. The output image patches are then assembled into a probability map that can be co-rendered with the histological image either alongside it or over it as an overlay. The probability map can then be stored linked to the histological image.Type: GrantFiled: December 21, 2018Date of Patent: August 11, 2020Assignee: LEICA BIOSYSTEMS IMAGING, INC.Inventors: Walter Georgescu, Allen Olson, Bharat Annaldas, Darragh Lawler, Kevin Shields, Kiran Saligrama, Mark Gregson
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Publication number: 20190206056Abstract: A convolutional neural network (CNN) is applied to identifying tumors in a histological image. The CNN has one channel assigned to each of a plurality of tissue classes that are to be identified, there being at least one class for each of non-tumorous and tumorous tissue types. Multi-stage convolution is performed on image patches extracted from the histological image followed by multi-stage transpose convolution to recover a layer matched in size to the input image patch. The output image patch thus has a one-to-one pixel-to-pixel correspondence with the input image patch such that each pixel in the output image patch has assigned to it one of the multiple available classes. The output image patches are then assembled into a probability map that can be co-rendered with the histological image either alongside it or over it as an overlay. The probability map can then be stored linked to the histological image.Type: ApplicationFiled: December 21, 2018Publication date: July 4, 2019Inventors: Walter GEORGESCU, Allen OLSON, Bharat ANNALDAS, Darragh LAWLER, Kevin SHIELDS, Kiran SALIGRAMA, Mark GREGSON
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Patent number: 10108779Abstract: Automatic nuclear segmentation. In an embodiment, a plurality of superpixels are determined in a digital image. For each of the superpixels, any superpixels located within a search radius from the superpixel are identified, and, for each unique local combination between the superpixel and any identified superpixels located within the search radius from the superpixel, a local score for the local combination is determined. One of a plurality of global sets of local combinations with an optimum global score is identified based on the determined local scores.Type: GrantFiled: December 12, 2016Date of Patent: October 23, 2018Assignee: LEICA BIOSYSTEMS IMAGING, INC.Inventors: Walter Georgescu, Kiran Saligrama, Allen Olson, Bharat Annaldas
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Publication number: 20180260609Abstract: Automated stain finding. In an embodiment, an image of a sample comprising one or more stains is received. For each of a plurality of pixels in the image, an optical density vector for the pixel is determined. The optical density vector comprises a value for each of the one or more stains, and represents a point in an optical density space that has a number of dimensions equal to a number of the one or more stains. The optical density vectors are transformed from the optical density space into a representation in a lower dimensional space. The lower dimensional space has a number of dimensions equal to one less than the number of dimensions of the optical density space. An optical density vector corresponding to each of the one or more stains is identified based on the representation.Type: ApplicationFiled: September 16, 2016Publication date: September 13, 2018Inventors: Walter Georgescu, Bharat Annaldas, Allen Olson, Kiran Saligrama
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Publication number: 20170300617Abstract: Automatic nuclear segmentation. In an embodiment, a plurality of superpixels are determined in a digital image. For each of the superpixels, any superpixels located within a search radius from the superpixel are identified, and, for each unique local combination between the superpixel and any identified superpixels located within the search radius from the superpixel, a local score for the local combination is determined. One of a plurality of global sets of local combinations with an optimum global score is identified based on the determined local scores.Type: ApplicationFiled: December 12, 2016Publication date: October 19, 2017Inventors: Walter GEORGESCU, Kiran SALIGRAMA, Allen OLSON, Bharat ANNALDAS