Abstract: Techniques discussed herein are directed to identifying health assessment data of a set of computing instances of a distributed computing system. The health assessment data may be collected from the computing instances and stored in a first distributed cache. When a request for health assessment data for one or more computing instances is received, the health assessment data may be retrieved from the first distributed cache, provided to the requesting entity, and stored in a second distributed cache. A subsequent request may cause new health assessment data to be retrieved from the first distributed cache and compared to the stored data of the second distributed cache. Changes in the health assessment data may be identified and data indicating those changes may be provided in response to the subsequent request. One or more remedial actions may be performed in response to the health assessment data obtained.

Abstract: A platform providing methods and systems for prevention and/or treatment of a health condition (e.g., mental health condition and/or weight-related condition), where a method can include: simultaneously reducing severity symptoms of the health condition and comorbid conditions upon: receiving a set of samples from one or more subjects; receiving a biometric dataset from one or more subjects; receiving a lifestyle dataset from one or more subjects; returning a genomic single nucleotide polymorphism (SNP) profile and a baseline microbiome state upon processing the set of samples, the biometric dataset, and the lifestyle dataset with a set of transformation operations; generating personalized intervention plans for the one or more subjects upon processing the genomic SNP profile and the baseline microbiome state with a multi-omic model; and executing the personalized intervention plans for the one or more subjects.

Abstract: Described herein is a system method for point in time blob restore. In response to receipt of a request to restore a particular blob range to a particular point in time, read and/or write operations on the particular blob range requested to be restored are blocked. Blob(s) in the particular blob range which have changed since the particular point in time are determined based, at least in part, upon information stored in a change log and/or a deleted blob store. A determination is made as to whether the requested restore operation can be performed, for example, based upon a restoration policy. When it is determined that the requested restore operation can be performed, blob(s) determined to have changed since the particular point in time based, at least in part, upon information stored in the change log and/or the deleted blob store are restored.

Abstract: The present Disclosure is directed to methods for inhibiting or suppressing metastasis of a tumor in a mammalian subject using a cysteamine product, e.g., cysteamine or cystamine or a derivative thereof. Also described herein is a method for treating pancreatic cancer in a mammalian subject by administering a cysteamine product described herein.

Abstract: Data-driven operating model (DDOM) systems and techniques are described to manage implementation, access, and promotion of digital services by a service provider system. In one example, the DDOM system includes a data aggregation module, a journey manager module and a segment manager module. The data aggregation module supports a unified data architecture that is then leverage by the journey and segment manager modules to support matrixed journey stage and segmentation of a data lake to provide insights that are not possible by a human being alone, that are usable to manage implementation, access, and promotion of digital services by a service provider system.

Abstract: Described herein is a system method for point in time blob restore. In response to receipt of a request to restore a particular blob range to a particular point in time, read and/or write operations on the particular blob range requested to be restored are blocked. Blob(s) in the particular blob range which have changed since the particular point in time are determined based, at least in part, upon information stored in a change log and/or a deleted blob store. A determination is made as to whether the requested restore operation can be performed, for example, based upon a restoration policy. When it is determined that the requested restore operation can be performed, blob(s) determined to have changed since the particular point in time based, at least in part, upon information stored in the change log and/or the deleted blob store are restored.

Abstract: The present Disclosure is directed to methods for inhibiting or suppressing metastasis of a tumor in a mammalian subject using a cysteamine product, e.g., cysteamine or cystamine or a derivative thereof. Also described herein is a method for treating pancreatic cancer in a mammalian subject by administering a cysteamine product described herein.

Abstract: The present Disclosure is directed to methods for inhibiting or suppressing metastasis of a tumor in a mammalian subject using a cysteamine product, e.g., cysteamine or cystamine or a derivative thereof. Also described herein is a method for treating pancreatic cancer in a mammalian subject by administering a cysteamine product described herein.

Abstract: The present disclosure is directed to methods for inhibiting or suppressing metastasis of a tumor in a mammalian subject using a cysteamine product, e.g., cysteamine or cystamine or derivatives thereof. Also described herein is a method for treating pancreatic cancer in a mammalian subject by administering a cysteamine product described herein.

Abstract: A clinical grid electrode system for seizure control through local cooling, mapping brain function and me provision of reversible functional ablation. The system includes a modular, scalable, cooling and sensing array composed of a plurality of cooling sensing elements. The system also includes a control system to which die cooling and sensing array is coupled for providing for control and monitoring of die cooling sensing elements making up the cooling and sensing array.

Abstract: A clinical grid electrode system for seizure control through local cooling, mapping brain function and me provision of reversible functional ablation. The system includes a modular, scalable, cooling and sensing array composed of a plurality of cooling sensing elements. The system also includes a control system to which die cooling and sensing array is coupled for providing for control and monitoring of die cooling sensing elements making up the cooling and sensing array.

Abstract: Sterically stabilized cationic liposomes (SSCL) encapsulating a K type oligodeoxynucleotide (ODN) including a CpG motif are disclosed. These SSCL encapuslating a K type ODN can be used to effectively deliver the ODN to a cell. A novel method is also disclosed for producing the SSCL encapsulating the K type ODN. Administration of the SSCL encapsulating a K type ODN and a chemotherapeutic agent, such as a chimeric molecule comprising a targeting molecule selected from the group consisting of an IL-13, and an anti-IL-13 receptor antibody; and an effector molecule selected from the group consisting of a Pseudomonas exotoxin, a Diphtheria toxin, and a radionuclide, can be used to dramatically reduce the growth of solid tumors.