Patents by Inventor Bharat K. Trivedi

Bharat K. Trivedi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • N-(substituted aryl)-N'-(substituted alkoxy)-ureas and thioureas as antihypercholesterolemic and antiatherosclerotic agents
    Patent number: 5155127
    Abstract: Novel N-[substituted aryl]-N'-(substituted alkoxy)-urea and thiourea derivatives are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful in preventing the intestinal absorption of cholesterol and thus are useful in the treatment of hypercholesterolemia and atherosclerosis.
    Type: Grant
    Filed: January 18, 1990
    Date of Patent: October 13, 1992
    Assignee: Warner-Lambert Company
    Inventor: Bharat K. Trivedi
  • Synthesis of bis (morpholinomethyl) derivatives of tricyclic bis (dioxopiperazines)
    Patent number: 5130426
    Abstract: Bis(morpholinomethyl) derivatives of tricyclic bisdioxopyperzaines of the formula ##STR1## wherein R is H, ##STR2## R' is H, lower alkyl groups (straight or branched chain of 1 to 6 carbon atoms) and the processes for the syntheses thereof are provided.
    Type: Grant
    Filed: June 27, 1985
    Date of Patent: July 14, 1992
    Assignee: Ohio State University
    Inventors: Donald T. Witiak, Bharat K. Trivedi
  • Cyclic beta-ketoamide ACAT inhibitors
    Patent number: 5118697
    Abstract: Novel cyclic beta-ketoamides which contain an aryl moiety having utility as blood cholesterol lowering agents rendering them useful in the treatment of atherosclerosis.
    Type: Grant
    Filed: March 6, 1991
    Date of Patent: June 2, 1992
    Assignee: Warner-Lambert Company
    Inventors: Corinne E. Augelli-Szafran, Bharat K. Trivedi
  • N-(((2,6-disubstituted)phenyl)-N-diarylalkyl)ureas as antihyperlipidemic and antiatherosclerotic agents
    Patent number: 5116848
    Abstract: Certain N-2,6-dialkyl- or N-2,6-dialkoxphenyl-N'-diarylalkylurea compounds are potent inhibitors of the enzyme acyl CoA:cholesterol acyltransferase (ACAT), and are thus useful agents for the treatment of hypercholesterolemia or atherosclerosis with urea and thiourea compounds.
    Type: Grant
    Filed: March 30, 1988
    Date of Patent: May 26, 1992
    Assignee: Warner-Lambert Company
    Inventor: Bharat K. Trivedi
  • Antihyperlipidemic and antiatherosclerotic compounds and compositions
    Patent number: 5030653
    Abstract: Certain N-2,6-dialkyl- or N-2,6-dialkoxyphenyl-N'-arylalkylurea compounds are potent inhibitors of the enzyme acyl CoA:cholesterol acyltransferase (ACAT), and are thus useful agents for the treatment of hypercholesterolemia or atherosclerosis.
    Type: Grant
    Filed: October 23, 1990
    Date of Patent: July 9, 1991
    Assignee: Warner-Lambert Company
    Inventor: Bharat K. Trivedi
  • Antihyperlipidemic and antiatherosclerotic urea and carbamate compounds
    Patent number: 5015644
    Abstract: Certain substituted urea, thiourea, carbamate, and thiocarbamate compounds are potent inhibitors of the enzyme acyl-CoA: cholesterol acyltransferase and are thus useful agents for inhibiting the intestinal absorption of cholesterol, and for lowering blood plasma cholesterol.
    Type: Grant
    Filed: June 1, 1989
    Date of Patent: May 14, 1991
    Assignee: Warner-Lambert Company
    Inventors: Bruce D. Roth, Bharat K. Trivedi
  • Antihyperlipidemic and antiatherosclerotic compounds and compositions
    Patent number: 4999373
    Abstract: Certain N-2,6-dialkyl- or N-2,6-dialkoxyphenyl-N'-arylalkylurea compounds are potent inhibitors of the enzyme acyl CoA: cholesterol acyltransferase (ACAT), and are thus useful agents for the treatment of hypercholesterolemia or atherosclerosis.
    Type: Grant
    Filed: February 9, 1990
    Date of Patent: March 12, 1991
    Assignee: Warner-Lambert Company
    Inventor: Bharat K. Trivedi
  • Antihyperlipidemic and antiatherosclerotic trisubstituted urea compounds
    Patent number: 4994465
    Abstract: Certain trisubstituted urea compounds as potent inhibitors of the enzyme acyl-CoA:cholesterol acyltransferase, their method of manufacture, pharmaceutical compositions containing such compounds as well as methods of inhibiting the interstitial absorption of cholesterol and lowering blood plasma cholesterol with such compounds as described.
    Type: Grant
    Filed: February 5, 1990
    Date of Patent: February 19, 1991
    Assignee: Warner-Lambert Company
    Inventor: Bharat K. Trivedi
  • Antihyperlipidemic and antiatherosclerotic compounds and compositions
    Patent number: 4948806
    Abstract: Certain N-2,6-dialkyl- or N-2,6-dialkoxyphenyl-N'-arylalkylurea compounds are potent inhibitors of the enzyme acyl CoA:cholesterol acyltransferase (ACAT), and are thus useful agents for the treatment of hypercholesterolemia or atherosclerosis.
    Type: Grant
    Filed: June 9, 1989
    Date of Patent: August 14, 1990
    Assignee: Warner-Lambert Company
    Inventor: Bharat K. Trivedi
  • N-(substituted aryl)-N'-(substituted alkoxy)-ureas and thioureas as antihypercholesterolemic and antiatherosclerotic agents
    Patent number: 4923896
    Abstract: Novel N-[substituted aryl]-N'-(substituted alkoxy)-urea and thiourea derivatives are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful in preventing the intestinal absorption of cholesterol and thus are useful in the treatment of hypercholesterolemia and atherosclerosis.
    Type: Grant
    Filed: February 9, 1989
    Date of Patent: May 8, 1990
    Assignee: Warner-Lambert Company
    Inventor: Bharat K. Trivedi
  • Antihyperlipidemic and antiatherosclerotic compounds and compositions
    Patent number: 4868210
    Abstract: Certain N-2,6-dialkyl- or N-2,6-dialkoxyphenyl-N'-arylalkylurea compounds are potent inhibitors of the enzyme acyl CoA:cholesterol acyltransferase (ACAT), and are thus useful agents for the treatment of hypercholesterolemia or atherosclerosis.
    Type: Grant
    Filed: March 30, 1988
    Date of Patent: September 19, 1989
    Assignee: Warner-Lambert Company
    Inventor: Bharat K. Trivedi
  • Diastereoisomers of n.sup.6 -endo-bicyclo[2.2.1]heptyladenosine as antihypertensives with selective action
    Patent number: 4837207
    Abstract: (1R-endo) or (1S-endo)-N-bicyclo[2.2.1]heptyl adenosine and pharmaceutically acceptable acid addition salts having highly desirable antihypertensive properties and unexpected A.sub.1 and A.sub.2 receptor binding activity, processes for their manufacture and pharmaceutical compositions and methods for using said compounds and compositions.
    Type: Grant
    Filed: May 13, 1987
    Date of Patent: June 6, 1989
    Assignee: Warner-Lambert Company
    Inventor: Bharat K. Trivedi
  • 2,N.sup.6 -disubstituted adenosines, derivatives and methods of use
    Patent number: 4791103
    Abstract: Novel N.sup.6 -substituted adenosines having desirable ratio of affinities at A1 or A2 receptors and highly desirable central nervous system and cardiovascular activities, such as analgesic, antipsychotic, sedative, or antihypertensive as well as immunoinflammatory activity.
    Type: Grant
    Filed: September 5, 1985
    Date of Patent: December 13, 1988
    Assignee: Warner-Lambert Company
    Inventors: Bharat K. Trivedi, Walter Moos, Harriet W. Hamilton, William C. Patt
  • (1,2,4)triazolo(4,3-a)quinoxaline-4-amines
    Patent number: 4780464
    Abstract: A unique series of [1,2,4]triazolo[4,3-a] quinoxaline-4-amine derivatives which show excellent binding affinity at both the A.sub.1 and A.sub.2 adenosine receptor sites. The compounds are useful in treating depression, fatigue, and heart failure. Also disclosed are methods for preparing the compounds, compositions containing the compounds and methods for using them.
    Type: Grant
    Filed: December 8, 1986
    Date of Patent: October 25, 1988
    Assignee: Warner-Lambert Company
    Inventor: Bharat K. Trivedi
  • N.sub.6 -Benzopyrano-and benzothiopyrano adenosines and methods of use
    Patent number: 4683223
    Abstract: N.sup.6 -Benzopyrano- and benzothiopyranoadenosines and pharmaceutically acceptable acid addition salts having highly desirable central nervous system antiinflammatory and antihypertensive properties, processes for their manufacture and pharmaceutical compositions and methods for using said compounds and compositions are described.
    Type: Grant
    Filed: September 9, 1985
    Date of Patent: July 28, 1987
    Assignee: Warner-Lambert Company
    Inventor: Bharat K. Trivedi
  • N.sup.6 -acenaphthyl adenosines and analogs thereof
    Patent number: 4673670
    Abstract: N.sup.6 -Acenaphthyl adenosines and analogs thereof and pharmaceutically acceptable acid addition salts having highly desirable blood pressure lowering properties, processes for their manufacture and pharmaceutical compositions and methods for using said compounds and compositions are described.
    Type: Grant
    Filed: April 30, 1986
    Date of Patent: June 16, 1987
    Assignee: Warner-Lambert Company
    Inventors: Harriet W. Hamilton, William C. Patt, Bharat K. Trivedi
  • N.sup.6 -tricyclic adenosines for treating hypertension
    Patent number: 4663313
    Abstract: N.sup.6 -Tricyclic adenosines and pharmaceutically acceptable acid addition salts having highly desirable central nervous system and cardiovascular properties, processes for their manufacture and pharmaceutical composition and methods for using said compounds and compositions are described.
    Type: Grant
    Filed: February 3, 1986
    Date of Patent: May 5, 1987
    Assignee: Warner-Lambert Company
    Inventors: James A. Bristol, Walter Moos, Bharat K. Trivedi
  • N.sup.6 -acenaphthyl adenosines and analogs thereof
    Patent number: 4614732
    Abstract: N.sup.6 -acenaphthyl adenosines and analogs thereof and pharmaceutically acceptable acid addition salts having highly desirable blood pressure lowering properties, processes for their manufacture and pharmaceutical compositions and methods for using said compounds and compositions are described.
    Type: Grant
    Filed: September 5, 1985
    Date of Patent: September 30, 1986
    Assignee: Warner-Lambert Company
    Inventors: Harriet W. Hamilton, William C. Patt, Bharat K. Trivedi
  • N.sup.6 -tricyclic adenosines
    Patent number: 4593019
    Abstract: N.sup.6 -Tricyclic adenosines and pharmaceutically acceptable acid addition salts having highly desirable central nervous system and cardiovascular properties, processes for their manufacture and pharmaceutical compositions and methods for using said compounds and compositions are described.
    Type: Grant
    Filed: October 26, 1984
    Date of Patent: June 3, 1986
    Assignee: Warner-Lambert Company
    Inventors: James A. Bristol, Walter Moos, Bharat K. Trivedi