Abstract: Disclosed is nicotine containing solid oral transmucosal dosage forms containing a therapeutically effective amount of nicotine polacrilex, citric acid monohydrate, sucrose and liquid glucose. The dosage form is preferably in the form of lozenge.

Abstract: Disclosed is nicotine containing solid oral transmucosal dosage forms containing a therapeutically effective amount of nicotine polacrilex, citric acid monohydrate, sucrose and liquid glucose. The dosage form is preferably in the form of lozenge.

Abstract: The present invention describes a novel controlled release multilayer composition that is capable of delivering a first active agent from one layer immediately followed by continuous controlled delivery of second active agent from matrix forming layer while the dosage form floats and is retained in the fluid of the environment. The floating bilayer system comprises of immediate release layer containing one active agent and a disintegrating agent whereas second floating matrix forming layer comprises a gas generating component, a gelling agent, and a second active agent. The present invention relates more particularly to a controlled release fluoroquinolone compositions, which maintain a therapeutically effective blood concentration of fluoroquinolone for duration with once a day administration.

Abstract: The present invention provides a novel floating osmotic device that is capable of delivering a first active agent in an outer coat immediately followed by continuous controlled delivery of second active agent from the osmotic core while the dosage form floats in the fluid of the environment. The floating osmotic device has of a compressed core containing active agent, a semipermeable membrane surrounding the core that is permeable to surrounding fluid and impermeable to the active agent, and an outer coating of a gas generating ingredient, a gelling agent, and a second active agent. Particular embodiments of the invention provide floating osmotic devices in which all two active agents are similar or dissimilar.

Abstract: Pharmaceutical dental gel preparation comprising of metronidazole benzoate, chlorhexidine gluconate, and local anesthetic as the active ingredient; glycol as the solvent medium; a carboxyvinyl polymer, cross-linked polymer of acrylic acid copolymerized with polyalkylsucrose as a gelling agent.