Patents by Inventor Bharathi Sriram

Bharathi Sriram has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PHAGE DERIVED ANTIMICROBIAL ACTIVITIES
    Publication number: 20220053775
    Abstract: The present invention provides methods and compositions to reduce growth of microbial colonies, including infections, and includes therapeutic compositions, methods for treatment of infections, and methods for identifying additional such compositions.
    Type: Application
    Filed: September 1, 2021
    Publication date: February 24, 2022
    Inventors: Sriram Padmanabhan, Vivek Daniel Paul, R. Sanjeev Saravanan, Bharathi Sriram
  • PHAGE DERIVED ANTIMICROBIAL ACTIVITIES
    Publication number: 20190297896
    Abstract: The present invention provides methods and compositions to reduce growth of microbial colonies, including infections, and includes therapeutic compositions, methods for treatment of infections, and methods for identifying additional such compositions.
    Type: Application
    Filed: April 8, 2019
    Publication date: October 3, 2019
    Inventors: Sriram Padmanabhan, Vivek Daniel Paul, R. Sanjeev Saravanan, Bharathi Sriram
  • Phage derived antimicrobial activities
    Patent number: 10278398
    Abstract: The present invention provides methods and compositions to reduce growth of microbial colonies, including infections, and includes therapeutic compositions, methods for treatment of infections, and methods for identifying additional such compositions.
    Type: Grant
    Filed: April 7, 2017
    Date of Patent: May 7, 2019
    Assignee: GangaGen, Inc.
    Inventors: Sriram Padmanabhan, Vivek Daniel Paul, R. Sanjeev Saravanan, Bharathi Sriram
  • REDUCING CONJUGATIVE PLASMIDS IN BACTERIA
    Publication number: 20190054129
    Abstract: The present invention provides methods and compositions to reduce prevalence of plasmids in microbial colonies, including infections, and includes therapeutic compositions, methods for treatment of infections, and methods for identifying additional such compositions. Means are provided to reduce the copy numbers of antibiotic resistance genes, and to confer phage binding to cells lacking receptors for those phage.
    Type: Application
    Filed: October 8, 2018
    Publication date: February 21, 2019
    Inventors: Chemira B. Appaiah, Jayasheela Manur, Bharathi Sriram
  • Reducing conjugative plasmids in bacteria
    Patent number: 10092608
    Abstract: The present invention provides methods and compositions to reduce prevalence of plasmids in microbial colonies, including infections, and includes therapeutic compositions, methods for treatment of infections, and methods for identifying additional such compositions. Means are provided to reduce the copy numbers of antibiotic resistance genes, and to confer phage binding to cells lacking receptors for those phage.
    Type: Grant
    Filed: November 23, 2015
    Date of Patent: October 9, 2018
    Assignee: GangaGen, Inc.
    Inventors: C. B. Appaiah, Jayasheela Manur, Bharathi Sriram
  • Chimeric antibacterial polypeptides
    Patent number: 9932569
    Abstract: Provided herein are antibacterial compositions and methods of making and using the compositions.
    Type: Grant
    Filed: February 21, 2017
    Date of Patent: April 3, 2018
    Assignee: GangaGen, Inc.
    Inventors: Chemira B Appaiah, Sriram Padmanabhan, R. Sanjeev Saravana, Bharathi Sriram
  • PHAGE DERIVED ANTIMICROBIAL ACTIVITIES
    Publication number: 20170318817
    Abstract: The present invention provides methods and compositions to reduce growth of microbial colonies, including infections, and includes therapeutic compositions, methods for treatment of infections, and methods for identifying additional such compositions.
    Type: Application
    Filed: April 7, 2017
    Publication date: November 9, 2017
    Inventors: SRIRAM PADMANABHAN, Vivek Daniel Paul, R. Sanjeev Saravanan, Bharathi Sriram
  • Incapacitated whole-cell immunogenic bacterial compositions produced by recombinant expression
    Patent number: 9801930
    Abstract: The present invention features incapacitated whole-cell bacterial immunogenic compositions and methods of their production, which compositions are useful to deliver antigens in a manner resembling the live infectious organism in terms of elicitation of a robust immune response, but with reduced risk or no risk of disease. The compositions of the invention are produced by rendering a bacterium bacteriostatic through expression of a recombinant promoter in the bacterial cell, which promoter can be operably linked to a polynucleotide encoding a recombinant gene product. In one embodiment, where the bacterium is a gram negative host, the recombinant gene product provides for reduced toxicity of LPS. In one embodiment, the gene product is a bacteriophage protein, such as endolysin, holin, or ndd.
    Type: Grant
    Filed: February 23, 2016
    Date of Patent: October 31, 2017
    Assignee: GangaGen, Inc.
    Inventors: Janakiraman Ramachandran, Padmanabhan Sriram, Bharathi Sriram
  • CHIMERIC ANTIBACTERIAL POLYPEPTIDES
    Publication number: 20170233706
    Abstract: Provided herein are antibacterial compositions and methods of making and using the compositions.
    Type: Application
    Filed: February 21, 2017
    Publication date: August 17, 2017
    Inventors: Chemira B Appaiah, Sriram Padmanabhan, R. Sanjeev Saravana, Bharathi Sriram
  • Phage derived antimicrobial activities
    Patent number: 9622486
    Abstract: The present invention provides methods and compositions to reduce growth of microbial colonies, including infections, and includes therapeutic compositions, methods for treatment of infections, and methods for identifying additional such compositions.
    Type: Grant
    Filed: May 15, 2014
    Date of Patent: April 18, 2017
    Assignee: Gangagen, Inc.
    Inventors: Sriram Padmanabhan, Vivek Daniel Paul, R. Sanjeev Saravanan, Bharathi Sriram
  • Chimeric antibacterial polypeptides
    Patent number: 9605250
    Abstract: Provided herein are antibacterial compositions and methods of making and using the compositions.
    Type: Grant
    Filed: April 12, 2012
    Date of Patent: March 28, 2017
    Assignee: Gangagen, Inc.
    Inventors: Chemira B. Appaiah, Sriram Padmanabhan, R. Sanjeev Saravanan, Bharathi Sriram
  • REDUCING CONJUGATIVE PLASMIDS IN BACTERIA
    Publication number: 20160310549
    Abstract: The present invention provides methods and compositions to reduce prevalence of plasmids in microbial colonies, including infections, and includes therapeutic compositions, methods for treatment of infections, and methods for identifying additional such compositions. Means are provided to reduce the copy numbers of antibiotic resistance genes, and to confer phage binding to cells lacking receptors for those phage.
    Type: Application
    Filed: November 23, 2015
    Publication date: October 27, 2016
    Inventors: C.B. Appaiah, Jayasheela Manur, Bharathi Sriram
  • INCAPACITATED WHOLE-CELL IMMUNOGENIC BACTERIAL COMPOSITIONS PRODUCED BY RECOMBINANT EXPRESSION
    Publication number: 20160199474
    Abstract: The present invention features incapacitated whole-cell bacterial immunogenic compositions and methods of their production, which compositions are useful to deliver antigens in a manner resembling the live infectious organism in terms of elicitation of a robust immune response, but with reduced risk or no risk of disease. The compositions of the invention are produced by rendering a bacterium bacteriostatic through expression of a recombinant promoter in the bacterial cell, which promoter can be operably linked to a polynucleotide encoding a recombinant gene product. In one embodiment, where the bacterium is a gram negative host, the recombinant gene product provides for reduced toxicity of LPS. In one embodiment, the gene product is a bacteriophage protein, such as endolysin, holin, or ndd.
    Type: Application
    Filed: February 23, 2016
    Publication date: July 14, 2016
    Inventors: Janakiraman Ramachandran, Padmanabhan Sriram, Bharathi Sriram
  • Incapacitated whole-cell immunogenic bacterial compositions produced by recombinant expression
    Patent number: 9289481
    Abstract: The present invention features incapacitated whole-cell bacterial immunogenic compositions and methods of their production, which compositions are useful to deliver antigens in a manner resembling the live infectious organism in terms of elicitation of a robust immune response, but with reduced risk or no risk of disease. The compositions of the invention are produced by rendering a bacterium bacteriostatic through expression of a recombinant promoter in the bacterial cell, which promoter can be operably linked to a polynucleotide encoding a recombinant gene product. In one embodiment, where the bacterium is a gram negative host, the recombinant gene product provides for reduced toxicity of LPS. In one embodiment, the gene product is a bacteriophage protein, such as endolysin, holin, or ndd.
    Type: Grant
    Filed: September 15, 2009
    Date of Patent: March 22, 2016
    Assignee: Gangagen, Inc.
    Inventors: Janakiraman Ramachandran, Sriram Padmanabhan, Bharathi Sriram
  • Reducing conjugative plasmids in bacteria
    Patent number: 9193946
    Abstract: The present invention provides methods and compositions to reduce prevalence of plasmids in microbial colonies, including infections, and includes therapeutic compositions, methods for treatment of infections, and methods for identifying additional such compositions. Means are provided to reduce the copy numbers of antibiotic resistance genes, and to confer phage binding to cells lacking receptors for those phage.
    Type: Grant
    Filed: March 10, 2009
    Date of Patent: November 24, 2015
    Assignee: Gangagen, Inc.
    Inventors: C. B. Appaiah, Jayashella Manur, Bharathi Sriram
  • PHAGE DERIVED ANTIMICROBIAL ACTIVITIES
    Publication number: 20140369986
    Abstract: The present invention provides methods and compositions to reduce growth of microbial colonies, including infections, and includes therapeutic compositions, methods for treatment of infections, and methods for identifying additional such compositions.
    Type: Application
    Filed: May 15, 2014
    Publication date: December 18, 2014
    Applicant: GangaGen, Inc.
    Inventors: Sriram Padmanabhan, Vivek Daniel Paul, R.Sanjeev Saravanan, Bharathi Sriram
  • Phage derived antimicrobial activities
    Patent number: 8748150
    Abstract: The present invention provides methods and compositions to reduce growth of microbial colonies, including infections, and includes therapeutic compositions, methods for treatment of infections, and methods for identifying additional such compositions.
    Type: Grant
    Filed: May 21, 2012
    Date of Patent: June 10, 2014
    Assignee: GangaGen, Inc.
    Inventors: Sriram Padmanabhan, Vivek Daniel Paul, R. Sanjeev Saravanan, Bharathi Sriram
  • CHIMERIC ANTIBACTERIAL POLYPEPTIDES
    Publication number: 20140050713
    Abstract: Provided herein are antibacterial compositions and methods of making and using the compositions.
    Type: Application
    Filed: April 12, 2012
    Publication date: February 20, 2014
    Inventors: C.B. Appaiah, Sriram Padmanabhan, R. Sanjeev Saravanan, Bharathi Sriram
  • DEFINED DOSE THERAPEUTIC PHAGE
    Publication number: 20120328576
    Abstract: The invention provides therapeutic, defined-dose anti-bacterial phage preparations, methods to make such preparations, methods to treat bacterial infections using such preparations and methods to diagnose bacterial infections using such preparations.
    Type: Application
    Filed: June 29, 2012
    Publication date: December 27, 2012
    Applicant: GangaGen, Inc.
    Inventors: Manur Jayasheela, Bharathi Sriram, Sriram Padmanabhan
  • PHAGE DERIVED ANTIMICROBIAL ACTIVITIES
    Publication number: 20120237491
    Abstract: The present invention provides methods and compositions to reduce growth of microbial colonies, including infections, and includes therapeutic compositions, methods for treatment of infections, and methods for identifying additional such compositions.
    Type: Application
    Filed: May 21, 2012
    Publication date: September 20, 2012
    Applicant: GangaGen, Inc.
    Inventors: Sriram Padmanabhan, Vivek Daniel Paul, R. Sanjeev Saravanan, Bharathi Sriram