Patents by Inventor Bhaskar C

Bhaskar C has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20150266903
    Abstract: A compound includes the structure of general Formula (II), pharmaceutically acceptable salts thereof, and/or solvates thereof: wherein R1, R2, R3, are independently selected from the group consisting of null, hydroxy, alkoxy, and halo, or R1 and R2 taken together form a cyclic boronate ester and R3 is null; wherein when four bonds to boron are present, boron bears a formal negative charge and the structure further comprises a countercation that is potassium or sodium, X1, X2, X3, and X4 are independently selected from the group consisting of O, CH, and N, with the proviso that no more than two of combined O and N are selected, and Z is selected from the group consisting of hydrogen, alkyl, aryl, heteroaryl, and halogen, any of which may be optionally substituted. Such compounds can increase glucose uptake by cells and preferably do not substantially increase adipogenesis.
    Type: Application
    Filed: October 16, 2013
    Publication date: September 24, 2015
    Inventors: Nikhil V. Dhurandhar, Bhaskar C. Das
  • Publication number: 20150166492
    Abstract: Compounds, compositions and methods are provided for selectively activating chaperone-mediated autophagy (CMA), protecting cells from oxidative stress, proteotoxicity and lipotoxicity, and/or antagonizing activity of retinoic acid receptor alpha (RAR?) in subjects in need thereof.
    Type: Application
    Filed: December 11, 2014
    Publication date: June 18, 2015
    Inventors: ANA MARIA CUERVO, EVRIPIDIS GAVATHIOTIS, QISHENG XIN, BHASKAR C. DAS
  • Patent number: 8669260
    Abstract: The application discloses ketoconazole derivatives that are antagonists of the human pregnane X receptor (PXR), methods of preparing the derivatives, uses of the derivatives with drug therapy, and methods of inhibiting tumor cell proliferation and multidrug resistance using inhibitors of PXR.
    Type: Grant
    Filed: January 27, 2009
    Date of Patent: March 11, 2014
    Assignee: Albert Einstein College of Medicine of Yeshiva University
    Inventors: Sridhar Mani, Bhaskar C. Das
  • Publication number: 20140051661
    Abstract: The present invention provides resveratrol-based boron-containing analog! methods of use thereof in treatment of dyslipidemias and cancer.
    Type: Application
    Filed: February 15, 2012
    Publication date: February 20, 2014
    Applicants: The Texas A&M University System, Albert Einstein College of Medicine of Yeshiva University
    Inventors: Bhaskar C. Das, Fajun Yang, Xiaoping Zhao, Jeffrey E. Pessin, Haihong Zong, Jun-Yuan Ji
  • Patent number: 8581005
    Abstract: The present invention relates to inhibitors of mitochondria-associated, granulocyte-macrophage colony stimulating factor signaling molecule (Magmas), and related compositions and uses thereof.
    Type: Grant
    Filed: March 16, 2010
    Date of Patent: November 12, 2013
    Assignee: Albert Einstein College of Medicine of Yeshiva University
    Inventors: Paul Jubinsky, Bhaskar C. Das, Mary K. Short
  • Patent number: 8460635
    Abstract: Synthetic peptidomimetic derivatives and phenyl group derivatives of Fenretinide (4-HPR) are disclosed, as are their uses as therapeutic, diagnostic and imaging agents for cancer and other diseases.
    Type: Grant
    Filed: March 11, 2009
    Date of Patent: June 11, 2013
    Assignee: Albert Einstein College of Medicine of Yeshiva University
    Inventors: Ganjam V. Kalpana, Bhaskar C. Das
  • Publication number: 20110236308
    Abstract: The present invention relates generally to chelation compounds, radionuclide metal chelate compounds, i.e., complexes, and radiolabeled targeting moieties, i.e., conjugates, formed therefrom, and methods of using these compounds, complexes and conjugates for diagnostic and therapeutic purposes. This invention is more particularly related to aryl bidentate isonitrile metal complexes generated by a chemical interaction of a metal salt oxide or weak complex of the metal with aryl isonitrile bidentate ligands.
    Type: Application
    Filed: April 17, 2007
    Publication date: September 29, 2011
    Applicant: The General Hospital Corporation
    Inventors: David R. Elmaleh, Timothy M. Shoup, Alan J. Fischman, Bhaskar C. Das
  • Publication number: 20110105522
    Abstract: The application discloses ketoconazole derivatives that are antagonists of the human pregnane X receptor (PXR), methods of preparing the derivatives, uses of the derivatives with drug therapy, and methods of inhibiting tumor cell proliferation and multidrug resistance using inhibitors of PXR.
    Type: Application
    Filed: January 27, 2009
    Publication date: May 5, 2011
    Inventors: Sridhar Mani, Bhaskar C. Das
  • Publication number: 20110091383
    Abstract: Synthetic peptidomimetic derivatives and phenyl group derivatives of Fenretinide (4-HPR) are disclosed, as are their uses as therapeutic, diagnostic and imaging agents for cancer and other diseases.
    Type: Application
    Filed: March 11, 2009
    Publication date: April 21, 2011
    Inventors: Ganjam V. Kalpana, Bhaskar C. Das