Abstract: A system comprises one or more observation stations. Each observation station of the one or more observation stations comprises a corresponding set of one or more sensors. Additionally, the system comprises one or more physical machines that implement a computation engine configured to receive first observation data from the one or more observation stations. The computation engine may use the first observation data to train a machine learning system. The computation engine may subsequently use the trained machine learning system to provide feedback regarding an additional instance of the observation subject. The computation engine outputs the feedback.

Abstract: A system for reviewing results of ultrasound examinations provides enhanced control over reviewed images. A review and imaging system receives additional data comprising one or more of additional ultrasound images generated using parameter settings different from those selected by and sonographer and earlier stage ultrasound data. An ultrasound machine may be configured to acquire and make the additional data available to the review and imaging system. The review and imaging system may provide a wide range of control options for obtaining optimized display of images based on the additional data.

Abstract: A system for delivering drugs or other molecules to the brain comprises an ultrasound imaging transducer configured to image structures such as the circle of Willis within a patient's head by way of a low attenuation acoustic window. The system includes a processor configured to register the ultrasound images to previously obtained images which also include the structures. The system includes ultrasound transducer elements operable to deliver ultrasound energy to a target region to cause the blood brain barrier to open. The system may include a drug delivery system that may be operated to deliver a drug to the patient in coordination with opening the blood brain barrier, Coordinates of the target region relative to the ultrasound imaging transducer are determined using registration information.

Abstract: Operations of computing devices are managed using one or more deep neural networks (DNNs), which may receive, as DNN inputs, data from sensors, instructions executed by processors, and/or outputs of other DNNs. One or more DNNs, which may be generative, can be applied to the DNN inputs to generate DNN outputs based on relationships between DNN inputs. The DNNs may include DNN parameters learned using one or more computing workloads. The DNN outputs may be, for example, control signals for managing operations of computing devices, predictions for use in generating control signals, warnings indicating an acceptable state is predicted, and/or inputs to one or more neural networks. The signals enhance performance, efficiency, and/or security of one or more of the computing devices. DNNs can be dynamically trained to personalize operations by updating DNN weights or other parameters.

Abstract: Systems and methods of generating and applying a synthetic neuromodulatory signal are described. A subject may be put under a particular condition that causes an effect in the subject. While the subject is under the condition, a recording of neurogram signals derived from the condition can be made from the subject. For example, neuronal signals traveling on the vagus nerve of the subject may be monitored and recorded. The neurogram may then be used to create a synthetic neuromodulatory signal that can be administered to a user. When the synthetic neuromodulatory signal is administered to the user, the user may experience the same effect as the subject that had been placed in the condition, even though the user was never put under the same condition.

Abstract: Ultrasound data is acquired by a synthetic aperture technique which uses multiple ultrasound transmissions from point sources. RF data is stored and processed. Doppler velocities for pixels in an insonified region are obtained by processing the stored data. One or more pan boxes may be provided. Doppler velocities may be determined by obtaining I and Q images for a plurality of frames and performing autocorrelation across the frames for some or all pixels in the frames.

Abstract: Ultrasound methods involve generating ultrasound using virtual point sources. Apodization may be applied selectively to transducer elements to provide improved uniformity of response. Virtual point sources may be located at positions that are independent of transducer geometry. The number and/or locations of virtual point sources may be selected to cover a region of interest with a reduced number of ultrasound transmissions.

Abstract: An ultrasound imaging method transmits ultrasound into a medium from a source and receives and samples signals resulting from interaction of the ultrasound with the medium for each of a plurality of sources. The sampled signals are stored. Criteria are applied to select subsets of the stored sampled signals. In some embodiments the criteria relate to locations of a source and/or receiving element corresponding to a sampled signal. Images are generated from the subsets.

Abstract: Ultrasound data is acquired by a synthetic aperture technique which uses multiple ultrasound transmissions from point sources. RF data is stored and processed. Doppler velocities for pixels in an insonified region are obtained by processing the stored data. One or more pan boxes may be provided. Doppler velocities may be determined by obtaining I and Q images for a plurality of frames and performing autocorrelation across the frames for some or all pixels in the frames.

Abstract: An ultrasound imaging method transmits ultrasound into a medium from a source and receives and samples signals resulting from interaction of the ultrasound with the medium for each of a plurality of sources. The sampled signals are stored. Criteria are applied to select subsets of the stored sampled signals. In some embodiments the criteria relate to locations of a source and/or receiving element corresponding to a sampled signal. Images are generated from the subsets.

Abstract: Systems and methods are disclosed for improving the resolution and quality of an image formed by signals from an array of receivers. Multiple receivers introduce variations in arrival times that can be less than the period of an operating signal, and also less than the period associated with a sampling operation. Thus, multiple receivers allow sampling of fine features of reflected signals that would be considered beyond the resolution associated with the operating signal. Use of multiple receivers also provides an effective sampling rate that is greater than the sampling rate of an individual receiver. Similar advantages can be obtained using multiple transmitters. Such advantageous features can be used to obtain high resolution images of objects in a medium in applications such as ultrasound imaging. Sub-Nyquist sampling is discussed. Accounting for the effects of refraction on pathlengths as a signal passes between two regions of different sound speed allows improved calculation of focus distances.

Abstract: Systems and methods are disclosed for improving the resolution and quality of an image formed by signals from an array of receivers. Multiple receivers introduce variations in arrival times that can be less than the period of an operating signal, and also less than the period associated with a sampling operation. Thus, multiple receivers allow sampling of fine features of reflected signals that would be considered beyond the resolution associated with the operating signal. Use of multiple receivers also provides an effective sampling rate that is greater than the sampling rate of an individual receiver. Similar advantages can be obtained using multiple transmitters. Such advantageous features can be used to obtain high resolution images of objects in a medium in applications such as ultrasound imaging. Sub-Nyquist sampling is discussed. Accounting for the effects of refraction on pathlengths as a signal passes between two regions of different sound speed allows improved calculation of focus distances.

Abstract: Velocity scale is automatically determined for ultrasound imaging. Receive signals corresponding to different pulse repetition intervals are used to estimate velocities. The different velocities are used to determine the velocity scale. For example, the different pulse repetition intervals are obtained by selecting different sets of signals from a group of signals for a scan line. As another example, the different pulse repetition intervals are obtained by transmitting for a scan line with changing, such as increasing, pulse repetition intervals. The lower pulse repetition interval of a pair of intervals associated with a sign change in the phase is used for the velocity scale. In yet another example, at least two demodulation frequencies are used for a broadband transmit in at least two sets, each set with a different pulse repetition interval. Velocities are estimated for a greater number of pulse repetition intervals than transmitted using the broadband pulses.

Abstract: Disclosed are an apparatus and method of adjusting gain of an ultrasound system 100. In particular, subject matter is disclosed for receiving an indication 102 of a rate of change in motion of an object 106, and adjusting a gain based 108, at least in part, on said rate of change in motion, where the gain is adjusted at least partially corresponding to the rate of change in motion of the object 106.

Abstract: Ultrasound transducer temperatures are measured in response to a temperature dependent property of the ultrasound transducer. The temperature is measured without addition of new electronics or hardware retrofits of the transducer. By implementing software and/or hardware on the ultrasound system rather than the transducer, the temperature is measured in order to provide a level of fault protection. The upgraded or new ultrasound system uses either old or new transducers while still providing temperature measurement. For example, the temperature of the lens or window is measured as a function of changes in attenuation or acoustic velocity. The receive beamformer already implemented on many ultrasound systems is used to measure a temperature dependent property of the lens or window. As another example, the dielectric constant or capacitance of one or more transducer elements is measured using additional hardware in the ultrasound system.

Abstract: Ultrasound transducer temperatures are measured in response to a temperature dependent property of the ultrasound transducer. The temperature is measured without addition of new electronics or hardware retrofits of the transducer. By implementing software and/or hardware on the ultrasound system rather than the transducer, the temperature is measured in order to provide a level of fault protection. The upgraded or new ultrasound system uses either old or new transducers while still providing temperature measurement. For example, the temperature of the lens or window is measured as a function of changes in attenuation or acoustic velocity. The receive beamformer already implemented on many ultrasound systems is used to measure a temperature dependent property of the lens or window. As another example, the dielectric constant or capacitance of one or more transducer elements is measured using additional hardware in the ultrasound system.

Abstract: Velocity scale is automatically determined for ultrasound imaging. Receive signals corresponding to different pulse repetition intervals are used to estimate velocities. The different velocities are used to determine the velocity scale. For example, the different pulse repetition intervals are obtained by selecting different sets of signals from a group of signals for a scan line. As another example, the different pulse repetition intervals are obtained by transmitting for a scan line with changing, such as increasing, pulse repetition intervals. The lower pulse repetition interval of a pair of intervals associated with a sign change in the phase is used for the velocity scale. In yet another example, at least two demodulation frequencies are used for a broadband transmit in at least two sets, each set with a different pulse repetition interval. Velocities are estimated for a greater number of pulse repetition intervals than transmitted using the broadband pulses.

Abstract: Disclosed are an apparatus and method of adjusting gain of an ultrasound system 100. In particular, subject matter is disclosed for receiving an indication 102 of a rate of change in motion of an object 106, and adjusting a gain based 108, at least in part, on said rate of change in motion, where the gain is adjusted at least partially corresponding to the rate of change in motion of the object 106.

Abstract: Ultrasound transducer temperatures are measured in response to a temperature dependent property of the ultrasound transducer. The temperature is measured without addition of new electronics or hardware retrofits of the transducer. By implementing software and/or hardware on the ultrasound system rather than the transducer, the temperature is measured in order to provide a level of fault protection. The upgraded or new ultrasound system uses either old or new transducers while still providing temperature measurement. For example, the temperature of the lens or window is measured as a function of changes in attenuation or acoustic velocity. The receive beamformer already implemented on many ultrasound systems is used to measure a temperature dependent property of the lens or window. As another example, the dielectric constant or capacitance of one or more transducer elements is measured using additional hardware in the ultrasound system.

Abstract: Bubble generation during a tissue ablation procedure is identified or detected. The ultrasound imaging is optimized to better detect generation of bubbles for more refined visualization and control of the ablation procedure. The generation of bubbles may alternatively or additionally be quantified to assist in control and/or diagnosis during an ablation procedure. Signals are generated based on the detection of a change in bubble characteristics. For example, the detection of type 2 or type 1 bubble generation is used to generate audio or visual warning signals. As another example, detection of type 1 or type 2 bubbles triggers generation of a control signal for increasing, decreasing or terminating the ablation energy. The generation of the control signal is performed automatically rather than relying on user visualization and reaction.