Abstract: The present disclosure relates to compositions and methods comprising peptide molecules that mimic the binding and functional properties of native antibodies relative to their respective targets. Some embodiments comprise peptide-drug conjugates (PDCs) comprising the mimic peptides disclosed herein. The targets of these mimic peptides include epidermal growth factor receptor (EGFR), and human epidermal growth factor receptor 2 (HER2), vascular endothelial growth factor (VEGF), programmed cell death protein 1 (PD-1), and programmed death-ligand 1 (PD-L1). The present disclosure comprises application of the knob-socket computational model to design antibody mimics for proteins.

Abstract: The present disclosure relates to compositions and methods comprising peptide molecules that mimic the binding and functional properties of native antibodies relative to their respective targets. Some embodiments comprise peptide-drug conjugates (PDCs) comprising the mimic peptides disclosed herein. The targets of these mimic peptides include epidermal growth factor receptor (EGFR), and human epidermal growth factor receptor 2 (HER2), vascular endothelial growth factor (VEGF), programmed cell death protein 1 (PD-1), and programmed death-ligand 1 (PD-L1). The present disclosure comprises application of the knob-socket computational model to design antibody mimics for proteins.

Abstract: Pharmaceutical compositions and formulations are provided herein comprising a phosphodiesterase type 5 inhibitor, such as sildenafil citrate; and, an adenosine receptor (A1, A2A, A2B, and A3 receptors) antagonist, such as caffeine, for (i) treating erectile dysfunction while (ii) inhibiting the lower of the blood pressure, (iii) increasing the bioavailability of the compositions, and (iv) reducing the Tmax in the subject. Methods of making and administering oral disintegrating tablets are also provided.

Abstract: The present disclosure relates to compositions and methods comprising peptide molecules that mimic the binding and functional properties of native antibodies relative to their respective targets. Some embodiments comprise peptide-drug conjugates (PDCs) comprising the mimic peptides disclosed herein. The targets of these mimic peptides include epidermal growth factor receptor (EGFR), and human epidermal growth factor receptor 2 (HER2), vascular endothelial growth factor (VEGF), programmed cell death protein 1 (PD-1), and programmed death-ligand 1 (PD-L1). The present disclosure comprises application of the knob-socket computational model to design antibody mimics for proteins.

Abstract: Pharmaceutical compositions and formulations are provided herein comprising a phosphodiesterase type 5 inhibitor, such as sildenafil citrate; and, an adenosine receptor (A1, A2A, A2B, and A3 receptors) antagonist, such as caffeine, for (i) treating erectile dysfunction while (ii) inhibiting the lower of the blood pressure, (iii) increasing the bioavailability of the compositions, and (iv) reducing the Tmax in the subject. Methods of making and administering oral disintegrating tablets are also provided.