Abstract: A method for preparing a stable gatifloxacin composition in oral dosage form, said method comprising: (a) mixing gatifloxacin or a pharmaceutically acceptable salt or hydrate thereof, a disintegrant, and a filler for a time sufficient to form a mixture; (b) compacting the mixture of Step (a) at a compaction force of about 1 kN to about 30 kN for a time sufficient to form a compact; (c) milling the compact of Step (b) to form a granulation; and (d) mixing the granulation of Step (c) with an effective amount of a lubricant for a time sufficient to produce a gatifloxacin composition having a tap density of at least about 0.50 g/mL.

Abstract: An extended-release antibiotic composition comprising at least one antibiotic, and greater than 50 weight percent, based on the total weight of the composition, of a polymer component, wherein said polymer component comprises at least one pharmaceutically acceptable hydrophilic polymer, and said polymer component has a viscosity of less than about 50 cps.