Patents by Inventor Bi-Yu Li

Bi-Yu Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Xseq
    Patent number: 11352714
    Abstract: Provided herein are methods for identification of an expression profile, a transcriptional profile, and/or an epigenetic profile from a cell-containing sample. Also provided are compositions for use in the disclosed methods.
    Type: Grant
    Filed: March 5, 2019
    Date of Patent: June 7, 2022
    Assignee: VERILY LIFE SCIENCES LLC
    Inventors: Jerrod Schwartz, Ci Chu, Charles Kim, Bi Yu Li, Xiaomi Du
  • Method for identification of genetic markers
    Patent number: 7300751
    Abstract: Methods are provided for identifying genetic markers and for determining methylation patterns using restriction endonucleases having degenerate recognition or cleavage sequences.
    Type: Grant
    Filed: September 6, 2002
    Date of Patent: November 27, 2007
    Assignee: Syngenta Participations AG
    Inventors: Bi-Yu Li, Xun Wang, Liang Shi
  • Method for identification, separation and quantitative measurement of nucleic acid fragments
    Patent number: 7202022
    Abstract: The invention relates to a new method for sequence-specific identification, separation and quantitative measurement of nucleic acid fragments. The invention is based on the use of restriction endonucleases that have degenerate bases in their recognition or cleavage sequence. The method has broad applications, including DNA fingerprinting, differential display of mRNA, mutation and polymorphism identification, diagnosis and drug screening.
    Type: Grant
    Filed: June 29, 2001
    Date of Patent: April 10, 2007
    Assignee: Syngenta Participations AG
    Inventors: Bi-Yu Li, Xun Wang, Liang Shi
  • Method for non-redundant library construction
    Patent number: 6727068
    Abstract: Provided are novel methods for the production of nucleic acid libraries having reduced redundancy. Also provided are methods for determination of changes in RNA expression associated with pathological conditions, and physiological or developmental state. Additional aspects provided non-redundant tags or probes produced by the disclosed methods and microarrays incorporating such tags.
    Type: Grant
    Filed: January 23, 2002
    Date of Patent: April 27, 2004
    Assignee: Syngenta Participations AG
    Inventors: Liang Shi, Xun Wang, Bi-Yu Li
  • Enzymatic ligation-based identification of nucleotide sequences
    Publication number: 20030170695
    Abstract: Disclosed herein are novel methods for use in the analysis of nucleic acids. Uses disclosed include polynucleotide expression analysis, detection of single nucleotide polymorphisms, detection of pathogens, and detection of genetically modified cells and organisms. The method can be practiced using purified preparations of nucleic acids or unpurified cell lysates. Also provided are diagnostic methods and kits for conducting the disclosed methods.
    Type: Application
    Filed: December 27, 2002
    Publication date: September 11, 2003
    Inventors: Liang Shi, Bi-Yu Li, Xun Wang
  • Method for identification of genetic markers
    Publication number: 20030165923
    Abstract: Methods are provided for identifying genetic markers and for determining methylation patterns using restriction endonucleases having degenerate recognition or cleavage sequences.
    Type: Application
    Filed: September 6, 2002
    Publication date: September 4, 2003
    Inventors: Bi-Yu Li, Xun Wang, Liang Shi
  • Method for identification, separation and quantitative measurement of nucleic acid fragments
    Publication number: 20030148276
    Abstract: The invention relates to a new method for sequence-specific identification, separation and quantitative measurement of nucleic acid fragments. The invention is based on the use of restriction endonucleases that have degenerate bases in their recognition or cleavage sequence. The method has broad applications, including DNA fingerprinting, differential display of mRNA, mutation and polymorphism identification, diagnosis and drug screening.
    Type: Application
    Filed: June 29, 2001
    Publication date: August 7, 2003
    Inventors: Bi-Yu Li, Xun Wang, Liang Shi
  • Enzymatic ligation-based identification of transcript expression
    Publication number: 20030082584
    Abstract: Disclosed herein are novel methods for use in the analysis of nucleic acids. Uses disclosed include polynucleotide expression analysis and detection of single nucleotide polymorphisms. Also provided are diagnostic methods and kits for conducting the disclosed methods.
    Type: Application
    Filed: June 28, 2002
    Publication date: May 1, 2003
    Inventors: Liang Shi, Bi-Yu Li, Xun Wang
  • Method for non-redundant library construction
    Publication number: 20030022192
    Abstract: Provided are novel methods for the production of nucleic acid libraries having reduced redundancy. Also provided are methods for determination of changes in RNA expression associated with pathological conditions, and physiological or developmental state. Additional aspects provided non-redundant tags or probes produced by the disclosed methods and microarrays incorporating such tags.
    Type: Application
    Filed: January 23, 2002
    Publication date: January 30, 2003
    Inventors: Liang Shi, Xun Wang, Bi-Yu Li