Patents by Inventor Bianca Johanna Josephina Maria Brundel

Bianca Johanna Josephina Maria Brundel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Geranyl geranyl acetone analogs and uses thereof
    Patent number: 9688651
    Abstract: The invention relates to novel therapeutic compounds, more in particular to biologically active analogs and uses thereof as medicament, for instance for the treatment of atrial fibrillation. Provided is a compound of the general formula (formula I) wherein R1 is H or a saturated or unsaturated aliphatic moiety comprising 1 to 8 C-atoms; and X is selected from the group consisting of moieties X1, X2, X3, X4, X5 and X6. Exemplary uses include the prevention or therapeutic treatment of a HSF1-mediated disease.
    Type: Grant
    Filed: April 19, 2013
    Date of Patent: June 27, 2017
    Assignees: Nyken Holding B.V., Rijksuniversiteit Groningen, Academisch Ziekenhuis Groningen
    Inventors: Bianca Johanna Josephina Maria Brundel, Hermannus Steen, André Heeres, Johannes Paulus Gerardus Seerden
  • Geranyl Geranyl Acetone Analogs and Uses Thereof
    Publication number: 20150152076
    Abstract: The invention relates to novel therapeutic compounds, more in particular to biologically active analogs and uses thereof as medicament, for instance for the treatment of atrial fibrillation. Provided is a compound of the general formula (formula I) wherein R1 is H or a saturated or unsaturated aliphatic moiety comprising 1 to 8 C-atoms; and X is selected from the group consisting of moieties X1, X2, X3, X4, X5 and X6. Exemplary uses include the prevention or therapeutic treatment of a HSF1-mediated disease.
    Type: Application
    Filed: April 19, 2013
    Publication date: June 4, 2015
    Applicants: NYKEN HOLDING B.V., ACADEMISCH ZIEKENHUIS GRONINGEN, RIJKSUNIVERSITEIT GRONINGEN
    Inventors: Bianca Johanna Josephina Maria Brundel, Hermannus Steen, André Heeres, Johannes Paulus Gerardus Seerden
  • Hsp and Supraventricular Arrhythmia
    Publication number: 20080161258
    Abstract: The invention relates to the field of biology, molecular biology and medicine More specifically, the invention relates to a method for at least in part preventing or delaying or decreasing damage to a cardiac cell induced by a supraventricular arrhythmia. The invention provides a method for preventing, delaying or decreasing damage to a cardiac cell induced by a supraventricular arrhythmia comprising increasing the amount of at least one heat shock protein (HSP) or a functional equivalent and/or a functional fragment thereof, e.g. HSP27 or its functional equivalent HSP25, in said cardiac cell.
    Type: Application
    Filed: December 9, 2005
    Publication date: July 3, 2008
    Inventors: Robert Henk Henning, Harm Harmannus Kampinga, Bianca Johanna Josephina Maria Brundel