Patents by Inventor Bianxiao Cui

Bianxiao Cui has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NANOPILLAR ELECTRODE DEVICES AND METHODS OF RECORDING ACTION POTENTIALS
    Publication number: 20210008363
    Abstract: This disclosure provide a nanopillar electrode device, comprising a substrate patterned with a plurality of metal pads. The device may further comprise a plurality of nanopillars electrode arrays, wherein each nanopillar electrode array is attached to the substrate above a metal pad and electrically connected to the pad. The device may further comprise and a chamber surrounding the nanopillar electrodes, which can be used for culturing cells of interest for recording action potentials. The nanopillar electrode device may be configured to apply a voltage through the nanopillar electrodes from a voltage source. Nanopillar electroporation may be used to increase the permeability of cell membranes to allow intracellular recording. Also provided are methods of device fabrication, and methods of use.
    Type: Application
    Filed: June 23, 2020
    Publication date: January 14, 2021
    Inventors: Bianxiao Cui, Yi Cui, Ziliang Lin, Chong Xie
  • NANOPILLAR ELECTRODE DEVICES AND METHODS OF RECORDING ACTION POTENTIALS
    Publication number: 20170296806
    Abstract: This disclosure provide a nanopillar electrode device, comprising a substrate patterned with a plurality of metal pads. The device may further comprise a plurality of nanopillars electrode arrays, wherein each nanopillar electrode array is attached to the substrate above a metal pad and electrically connected to the pad. The device may further comprise and a chamber surrounding the nanopillar electrodes, which can be used for culturing cells of interest for recording action potentials. The nanopillar electrode device may be configured to apply a voltage through the nanopillar electrodes from a voltage source. Nanopillar electroporation may be used to increase the permeability of cell membranes to allow intracellular recording. Also provided are methods of device fabrication, and methods of use.
    Type: Application
    Filed: June 30, 2017
    Publication date: October 19, 2017
    Inventors: Bianxiao Cui, Yi Cui, Ziliang Lin, Chong Xie
  • Nanopillar electrode devices and methods of recording action potentials
    Patent number: 9724506
    Abstract: This disclosure provide a nanopillar electrode device, comprising a substrate patterned with a plurality of metal pads. The device may further comprise a plurality of nanopillars electrode arrays, wherein each nanopillar electrode array is attached to the substrate above a metal pad and electrically connected to the pad. The device may further comprise and a chamber surrounding the nanopillar electrodes, which can be used for culturing cells of interest for recording action potentials. The nanopillar electrode device may be configured to apply a voltage through the nanopillar electrodes from a voltage source. Nanopillar electroporation may be used to increase the permeability of cell membranes to allow intracellular recording. Also provided are methods of device fabrication, and methods of use.
    Type: Grant
    Filed: January 30, 2014
    Date of Patent: August 8, 2017
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Bianxiao Cui, Yi Cui, Ziliang Lin, Chong Xie
  • NANOPILLAR ELECTRODE DEVICES AND METHODS OF RECORDING ACTION POTENTIALS
    Publication number: 20140222123
    Abstract: This disclosure provide a nanopillar electrode device, comprising a substrate patterned with a plurality of metal pads. The device may further comprise a plurality of nanopillars electrode arrays, wherein each nanopillar electrode array is attached to the substrate above a metal pad and electrically connected to the pad. The device may further comprise and a chamber surrounding the nanopillar electrodes, which can be used for culturing cells of interest for recording action potentials. The nanopillar electrode device may be configured to apply a voltage through the nanopillar electrodes from a voltage source. Nanopillar electroporation may be used to increase the permeability of cell membranes to allow intracellular recording. Also provided are methods of device fabrication, and methods of use.
    Type: Application
    Filed: January 30, 2014
    Publication date: August 7, 2014
    Inventors: Bianxiao Cui, Yi Cui, Ziliang Lin, Chong Xie