Abstract: A display substrate and a display device are provided. The display substrate includes a first power signal line and a pixel defining layer. The first power signal line includes first power signal sub-lines extending along a first direction and second power signal sub-lines extending along a second direction. The pixel defining layer includes a plurality of openings to define effective light-emitting regions of a plurality of sub-pixels, the plurality of sub-pixels include a sub-pixel pair including two sub-pixels arranged along the second direction, and the sub-pixel pair includes two effective light-emitting sub-regions with an interval therebetween. In a plan view, the first power signal sub-line passes through the interval between the two effective light-emitting sub-regions, at least one second power signal sub-line includes a fracture, and the two effective light-emitting sub-regions are located at the fracture.

Abstract: This application provides a port identification method, apparatus, and system, and belongs to the field of optical communications technologies. According to this application, a connection relationship between the ONT and the optical splitter and a connection relationship between the ONT and the port of the optical splitter can be accurately identified.

Abstract: A splitter includes an optical input section, N optical branch sections, and at least (N?1) optical filter structures. Each optical filter structure reflects an optical signal of one wavelength. The at least (N?1) optical filter structures include a special optical filter structure and at least (N?3) common optical filter structures, and a wavelength of an optical signal reflected by each of the common optical filter structures is a common wavelength. A wavelength of an optical signal reflected by a first/second special optical filter structure is a first/second special wavelength. At least (N?3) common wavelengths constitute an arithmetic sequence, a difference between the first special wavelength and a largest common wavelength is greater than a tolerance of the arithmetic sequence, and a difference between the second special wavelength and a smallest common wavelength is greater than the tolerance of the arithmetic sequence.

Abstract: A display substrate and a display device are provided. The display substrate includes a first power signal line and a pixel defining layer. The first power signal line includes first power signal sub-lines extending along a first direction and second power signal sub-lines extending along a second direction. The pixel defining layer includes a plurality of openings to define effective light-emitting regions of a plurality of sub-pixels, the plurality of sub-pixels include a sub-pixel pair including two sub-pixels arranged along the second direction, and the sub-pixel pair includes two effective light-emitting sub-regions with an interval therebetween. In a plan view, the first power signal sub-line passes through the interval between the two effective light-emitting sub-regions, at least one second power signal sub-line includes a fracture, and the two effective light-emitting sub-regions are located at the fracture.

Abstract: A display substrate and a display device are provided. The display substrate includes a first power signal line and a pixel defining layer. The first power signal line includes first power signal sub-lines extending along a first direction and second power signal sub-lines extending along a second direction. The pixel defining layer includes a plurality of openings to define effective light-emitting regions of a plurality of sub-pixels, the plurality of sub-pixels include a sub-pixel pair including two sub-pixels arranged along the second direction, and the sub-pixel pair includes two effective light-emitting sub-regions with an interval therebetween. In a plan view, the first power signal sub-line passes through the interval between the two effective light-emitting sub-regions, at least one second power signal sub-line includes a fracture, and the two effective light-emitting sub-regions are located at the fracture.

Abstract: A display substrate and a manufacturing method thereof, and a display device are disclosed. The display substrate includes a base substrate, a plurality of sub-pixels, at least one group of contact pads, and a first insulation layer. The base substrate includes a display region and a bonding region located at one side of the display region. At least one group of contact pads includes a plurality of contact pads, at least one of the plurality of contact pads includes a first contact pad metal layer and a second contact pad metal layer, the second contact pad metal layer covers an edge of the first contact pad metal layer. The first insulation layer is located in gaps between the plurality of contact pads and covers edges of the plurality of contact pads, and is configured to expose surfaces of the plurality of contact pads facing away from the base substrate.

Abstract: The present invention relates to an engineered human factor VIII polypeptide, which includes at least two substituted amino acids in A1 domain of hFVIII. In some embodiments, the substituted amino acids comprise L50V and L152P. In some embodiments, the substituted amino acids further comprise one or more of amino acid substitutions selected from the group consisting of D20S, G22L, I61T, D115E, F129I, G132D, Q139E, and L159F. The present invention also relates to engineered hFVIII polypeptide encoding nucleic acid fragment, an expression vector or a rAAV vector contains such nucleic acid fragment, and a method of using engineered hFVIII polypeptide to treat hemophilia A patients.

Abstract: A display panel includes: a base substrate, a third conductive layer, and a fourth conductive layer. The third conductive layer is located on one side of the base substrate and includes multiple first signal lines, where orthographic projections of the first signal lines on the base substrate are spaced apart in a first direction and extend along a second direction, and the first direction intersects with the second direction. The fourth conductive layer is located on the side of the third conductive layer away from the base substrate and includes multiple connection line segments, where orthographic projections of the connection line segments on the base substrate extend along the first direction, and a same connection line segment is respectively connected to a plurality of first signal lines through via holes.

Abstract: An array substrate is provided. The array substrate includes a node connecting line in a same layer as a respective voltage supply line, connected to a first capacitor electrode and a semiconductor material layer. An orthographic projection of a first anode on a base substrate at least partially overlaps with an orthographic projection of a node connecting line in a respective first subpixel. An orthographic projection of a second anode on the base substrate at least partially overlaps with an orthographic projection of the node connecting line in a respective second subpixel. An orthographic projection of a third anode on the base substrate at least partially overlaps with an orthographic projection of the node connecting line in a respective third subpixel. An orthographic projection of a fourth anode on the base substrate at least partially overlaps with an orthographic projection of the node connecting line in a respective fourth subpixel.

Abstract: In one aspect, present invention provides a recombinant mutant human factor VIII having increased expression and/or secretion as compared to wild-type factor VIII. In certain embodiments, the recombinant factor VIII includes one or more amino acid substitution(s) selected from the group consisting of 186, Y105, A108, D115, Q117, F129, G132, H134, M147 and L152. In other aspects, the present invention provides FVIII encoding nucleic acids, FVIII-expression vectors, as well as methods of using the modified FVIII genes in the treatment of FVIII deficiencies, such as hemophilia A.

Abstract: In one aspect, present invention provides a recombinant mutant human factor VIII having increased expression and/or secretion as compared to wild-type factor VIII. In certain embodiments, the recombinant factor VIII includes one or more amino acid substitution(s) selected from the group consisting of I86, Y105, A108, D115, Q117, F129, G132, H134, M147 and L152. In other aspects, the present invention provides FVIII encoding nucleic acids, FVIII-expression vectors, as well as methods of using the modified FVIII genes in the treatment of FVIII deficiencies, such as hemophilia A.

Abstract: In one aspect, present invention provides a recombinant mutant human factor VIII having increased expression and/or secretion as compared to wild-type factor VIII. In certain embodiments, the recombinant factor VIII includes one or more amino acid substitution(s) selected from the group consisting of I86, Y105, A108, D115, Q117, F129, G132, H134, M147 and L152. In other aspects, the present invention provides FVIII encoding nucleic acids, FVIII-expression vectors, as well as methods of using the modified FVIII genes in the treatment of FVIII deficiencies, such as hemophilia A.