Abstract: This invention relates to indolizine derivatives and their use in medicine. In particular, the present invention discloses novel substituted indolizine derivatives of formula I, or an isotopically labeled compound thereof, or an optical isomer thereof, a geometric isomer thereof, a tautomer thereof or a mixture of various isomers, or a pharmaceutically acceptable salt thereof, or a prodrug thereof. The invention also relates to the use of these compounds in medicine.

Abstract: A system and method are provided for manufacturing a tower structure. Accordingly, one or more layers of a wall element are deposited with a printhead assembly. At least one recess is defined in the wall element. The recess(es) has a single, circumferential opening positioned along an inner reference curve or an outer reference curve of the wall element. The recess(es) also has a depth which extends in a radial direction and intersects a midline reference curve. A reinforcing element is placed entirely within the recess(es) at the midline reference curve.

Abstract: Example split valves for regulating a first flowrate and a second flowrate of a fluid within a closed loop systems are disclosed herein. An example split valve includes an electrohydraulic servo valve coupled to a first piston via a first hydraulic flowline and a second hydraulic flowline, the first piston to include a piston shaft, a first head, and a second head; one or more bellows fixed to at least one of the first head or the second head, the one or more bellows to hermetically seal the fluid from a hydraulic fluid; and a control system connected to the electrohydraulic servo valve, the control system to adjust the first flowrate and the second flowrate of the fluid through a first fluid chamber, the first piston to be located in the first fluid chamber.

Abstract: A method and system of additively-manufacturing a structure having a reinforced access opening includes printing, via an additive printing device having at least one printer head, a portion of the structure adjacent to a support surface. The portion of the structure is printed of a cementitious material, and the printed portion of the structure defines an access opening for the structure. Moreover, the method includes providing a void of the cementitious material at a top boundary of the access opening, placing one or more reinforcement members in the void such that the one or more reinforcement members extend across the void, and continuing to print the printed portion of the structure around the void to build up the structure. Thus, the method also includes backfilling the void with a backfill material to incorporate the one or more reinforcement members within the void into the printed portion of the structure.

Abstract: A method and system of additively-manufacturing a structure having a reinforced access opening includes printing, via an additive printing device having at least one printer head, a portion of the structure adjacent to a support surface. The portion of the structure is printed of a cementitious material, and the printed portion of the structure defines an access opening for the structure. Moreover, the method includes providing a void of the cementitious material at a top boundary of the access opening, placing one or more reinforcement members in the void such that the one or more reinforcement members extend across the void, and continuing to print the printed portion of the structure around the void to build up the structure. Thus, the method also includes backfilling the void with a backfill material to incorporate the one or more reinforcement members within the void into the printed portion of the structure.

Abstract: A thermal structure for management of thermal energy, the thermal structure including: a first wall structure defining a first cavity; a second wall structure defining a second cavity, the second cavity in fluid communication with the first cavity; and a barrier cavity defined at least in-part by the first wall structure and the second wall structure, wherein the barrier cavity is disposed between the first cavity and the second cavity and includes a pressurized barrier fluid therein or is configured to receive the pressurized barrier fluid during operation of the thermal structure.

Abstract: A method of manufacturing a tower structure includes providing an additive printing device having at least one printer head atop a support surface. The method also includes positioning a pre-fabricated component adjacent to the support surface. The pre-fabricated component is constructed of a composite material reinforced with a plurality of reinforcement members. Further, portions of the plurality of reinforcement members protrude from the composite material. Moreover, the method includes printing and depositing, via the at least one printer head, a cementitious material onto the support surface to build up the tower structure layer by layer around the pre-fabricated component. Thus, the portions of the plurality of reinforcement members that protrude from the composite material reinforce the cementitious material around the pre-fabricated component.

Abstract: A method for monitoring at least one rotor blade of a wind turbine includes implementing, via a controller, a control scheme for monitoring blade damage of the at least one rotor blade. The control scheme includes monitoring at least one electrical condition of a pitch system of the wind turbine. The method also includes converting the electrical condition(s) of the pitch system into a frequency domain. Further, the method includes determining one or more peaks of the frequency domain around a frequency component related to a natural frequency of the rotor blade. Moreover, the method includes determining a frequency deviation between the one or more peaks of the frequency domain and the frequency component related to the natural frequency of the rotor blade. As such, a frequency deviation outside of a predetermined frequency range is indicative of a rotor blade anomaly. Thus, the method includes implementing a control action when the frequency deviation is outside of the predetermined frequency range.

Abstract: A system and method are provided for manufacturing a tower structure. Accordingly, one or more layers of a wall element are deposited with a printhead assembly. At least one recess is defined in the wall element. The recess(es) has a single, circumferential opening positioned along an inner reference curve or an outer reference curve of the wall element. The recess(es) also has a depth which extends in a radial direction and intersects a midline reference curve. A reinforcing element is placed entirely within the recess(es) at the midline reference curve.

Abstract: A method of manufacturing a tower structure includes providing an additive printing device having at least one printer head atop a support surface. The method also includes positioning a pre-fabricated component adjacent to the support surface. The pre-fabricated component is constructed of a composite material reinforced with a plurality of reinforcement members. Further, portions of the plurality of reinforcement members protrude from the composite material. Moreover, the method includes printing and depositing, via the at least one printer head, a cementitious material onto the support surface to build up the tower structure layer by layer around the pre-fabricated component. Thus, the portions of the plurality of reinforcement members that protrude from the composite material reinforce the cementitious material around the pre-fabricated component.

Abstract: A method for manufacturing a tower structure of a wind turbine at a wind turbine site. The method includes determining an optimized shape of the tower structure based on one or more site parameters. Further, the optimized shape of the tower structure is non-symmetrical. In a further step, the method include printing, via an additive printing device, the optimized shape of the tower structure of the wind turbine at the wind turbine site, at least in part, of a cementitious material. In addition, the method includes allowing the cementitious material to cure so as to form the tower structure of the wind turbine.

Abstract: An additive printing device and a method for using the same to manufacture a tower structure of a wind turbine is provided. The additive printing device includes a vertical support structure, a support ring suspended from the vertical support structure, and a printer head movably coupled to the support ring for selectively depositing cementitious material. A drive mechanism, such as a rack and pinion, moves the printer head around the support ring while selectively depositing cementitious material. The vertical support structure may be raised and/or the relative position between the vertical support structure and the printer head may be adjusted to raise the printer head to print subsequent layers. This process may be repeated to print the tower structure layer-by-layer from the ground up.

Abstract: A method for manufacturing a tower structure of a wind turbine includes printing, via an additive printing device, the tower structure of the wind turbine of a cementitious material. During printing, the method includes embedding one or more reinforcement sensing elements at least partially within the cementitious material at one or more locations. Thus, the reinforcement sensing element(s) are configured for sensing structural health of the tower structure, sensing temperature of the cementitious material, heating to control cure time of the cementitious material, and/or reinforcing the cementitious material. In addition, the method includes curing the cementitious material so as to form the tower structure.

Abstract: A method for manufacturing a tower structure of a wind turbine includes printing, via an additive printing device, a plurality of concentric sections of the tower structure of the wind turbine. The concentric sections may be printed simultaneously from concrete, may include tensioning cables or other structural supports, and may define other support flanges or overhangs. After curing, the method may include raising an inner section of the plurality of concentric sections to a top of an adjacent outer section and joining the two sections. This process may be repeated to telescope the concentric sections and raise the tower structure.

Abstract: Systems and methods of wind power generation in electrical power systems are described. According to one aspect, a wind turbine system can include a down tower portion having a main transformer configured to transform medium voltage power to another voltage power, a tower portion having one or more medium voltage cables configured to transmit medium voltage power, and, a nacelle portion. The nacelle portion can include a generator comprising a stator and a rotor. The stator may be connected to one or more medium voltage cables via a stator power path. The nacelle portion also includes a power converter coupled to the rotor of the generator, and, a step-up transformer coupled to the power converter and the one or more medium voltage cables. The step-up transformer can be configured to step-up low voltage power to medium voltage power.

Abstract: A wind turbine system includes a wind turbine generator having a rotor and a nacelle mounted atop a tower structure. The tower structure is mounted to a foundation structure and includes a plurality of tower sections, each including one or more tower section flanges. The wind turbine system further includes one or more connector rings. Each of the one or more connector rings is disposed proximate two adjacent tower section flanges and includes a plurality of pad eye adaptors each having an opening formed therein. The wind turbine system further includes a plurality of tensioned cables, with each coupled to one of the pad eye adaptors at a first end and the foundation structure at a second end. The plurality of tensioned cables are coupled to the tower structure at different or multiple connector ring heights based on site conditions to yield the desired lateral stability.

Abstract: Systems and methods of wind power generation in electrical power systems are described. According to one aspect, a wind turbine system can include a down tower portion having a main transformer configured to transform medium voltage power to another voltage power, a tower portion having one or more medium voltage cables configured to transmit medium voltage power, and, a nacelle portion. The nacelle portion can include a generator comprising a stator and a rotor. The stator may be connected to one or more medium voltage cables via a stator power path. The nacelle portion also includes a power converter coupled to the rotor of the generator, and, a step-up transformer coupled to the power converter and the one or more medium voltage cables. The step-up transformer can be configured to step-up low voltage power to medium voltage power.

Abstract: A crane system for a wind turbine is disclosed. The crane system includes a support structure, a movable structure, a slidable device, a first actuator unit, and a plurality of second actuator units. The slidable device includes a base, a retention component, and first, second, third, and fourth pairs of clamping arms. The base is coupled to the support structure. The retention component is coupled to either side of the base to define a channel between the retention component and the base. The first and second pairs of clamping arms are spaced apart and coupled to each other and to the base. The third and fourth pairs of clamping arms are disposed within the channel, spaced apart, and coupled to each other. The first actuator unit is coupled to the slidable device and each second actuator unit is coupled to the first, second, third, and fourth pairs of clamping arms.

Abstract: A multi-material tower section for a tower mast. The tower mast comprised of at least one multi-material tower section and a method for manufacturing the section. The section comprises at least one additively manufactured wall structure comprised of at least one first material and a plurality of additively manufactured internal reinforcement structures comprised of at least one additional material and disposed therewith the at least one additively manufactured wall structure.

Abstract: A wind turbine system includes a wind turbine generator having a rotor and a nacelle mounted atop a tower structure. The tower structure is mounted to a foundation structure and includes a plurality of tower sections, each including one or more tower section flanges. The wind turbine system further includes one or more connector rings. Each of the one or more connector rings is disposed proximate two adjacent tower section flanges and includes a plurality of pad eye adaptors each having an opening formed therein. The wind turbine system further includes a plurality of tensioned cables, with each coupled to one of the pad eye adaptors at a first end and the foundation structure at a second end. The plurality of tensioned cables are coupled to the tower structure at different or multiple connector ring heights based on site conditions to yield the desired lateral stability.