Abstract: Provided is the use of an aromatic ring drug in inhibiting a key transcription factor of malignant melanoma. In particular, provided is the use of a compound as represented by formula A, or an optical isomer thereof or a racemate thereof, or a solvate thereof, or a pharmaceutically acceptable salt thereof in the preparation of a pharmaceutical composition or preparation. The pharmaceutical composition or preparation is used for: (a) inhibiting a key transcriptional regulatory factor of malignant melanoma, namely MITF (Microphthalmia-associated Transcription Factor); (b) treating MITF-related diseases such as melanoma, pancreatic cancer, skin hypersensitivity and asthma; and (c) regulating physiological activities in which MITF is involved, such as skin whitening. In the formula, each group is as defined in the description.

Abstract: Systems and methods may aggregate and organize implicit and explicit initialization, reset, and termination operations defined throughout the hierarchy of an executable. The systems and methods may analyze the model and identify implicit and explicit initialization, reset, and termination operations defined at various hierarchical levels. The systems and methods may aggregate the implicit and explicit initialization, reset, and termination operations into an initialize callable unit, a reset callable unit, and a termination callable unit. The systems and methods may apply optimizations to the callable units, and resolve conflicts. The systems and methods may define a single entry point for each of the initialize, reset, and termination callable units.

Abstract: Disclosed are a retinoid compound, a preparation method therefor, intermediates thereof and an application thereof. The retinoid compound I of the present invention has a good tumor growth inhibition rate.

Abstract: Embodiments of the present disclosure relate to the field of computer technologies and, in particular, to an open-source-license analyzing method and apparatus, including: receiving a file-to-be-tested and a planning condition; detecting an open-source license involved in the file-to-be-tested; matching the detected open-source license with the planning condition to determine a first conflict between the detected open-source license and the planning condition; and generating a first risk assessment report based on the first conflict. The embodiments of the present disclosure are used to analyze and evaluate the risk of using open-source licenses.

Abstract: Disclosed are a retinoid compound, a preparation method therefor, intermediates thereof and an application thereof. The retinoid compound I of the present invention has a good tumor growth inhibition rate.

Abstract: Provided are compounds generated by conjugation of triptolide with glucose to form glucose-triptolide conjugates, provides compounds with effective anti-proliferative activity and improved tolerability as compared to naturally occurring triptolide compounds.

Abstract: Systems and methods decouple model components from a model execution style for which the model components are created, and the model components may be utilized in parent models having different execution styles. A model component may be partitioned into executable entities, and the entry points of the executable entities and their call styles may be identified. An adaptation layer that includes access points for the entry points may be constructed. The model component, including the adaptation layer, may be included in the model, and connection elements of the parent model may be connected to the access points of the adaptation layer. The execution call styles associated with the connection elements of the parent model may be bound to the execution call styles of the entry points as originally designed. The adaptation layer may manage translation of call styles and may coordinate scheduling of data communication with the model component.

Abstract: Systems and methods may aggregate and organize implicit and explicit initialization, reset, and termination operations defined throughout the hierarchy of an executable. The systems and methods may analyze the model and identify implicit and explicit initialization, reset, and termination operations defined at various hierarchical levels. The systems and methods may aggregate the implicit and explicit initialization, reset, and termination operations into an initialize callable unit, a reset callable unit, and a termination callable unit. The systems and methods may apply optimizations to the callable units, and resolve conflicts. The systems and methods may define a single entry point for each of the initialize, reset, and termination callable units.

Abstract: A device may receive a model including a group of blocks, and may receive a command to execute the model. The device may assign a parameter sample time to a subset of blocks of the group of blocks. The parameter sample time may permit a block, of the subset of blocks, to be executed based on a parameter change event detected during the execution of the model. The device may cause the model to be executed after assigning the parameter sample time to the subset of blocks. The device may detect a parameter change event, associated with the model, prior to the execution of the model being completed. The parameter change event may include an event that is external to the execution of the model. The device may cause at least one block, of the subset of blocks, to be executed based on the detecting the parameter change event.

Abstract: A device may receive a model including a group of blocks, and may receive a command to execute the model. The device may assign a parameter sample time to a subset of blocks of the group of blocks. The parameter sample time may permit a block, of the subset of blocks, to be executed based on a parameter change event detected during the execution of the model. The device may cause the model to be executed after assigning the parameter sample time to the subset of blocks. The device may detect a parameter change event, associated with the model, prior to the execution of the model being completed. The parameter change event may include an event that is external to the execution of the model. The device may cause at least one block, of the subset of blocks, to be executed based on the detecting the parameter change event.

Abstract: A system for providing model level protection for resources holding data accessed by multiple tasks in a model is discussed. The protection occurs at the model level so that the protection mechanism does not interfere with model dynamics. Resources concurrently accessed by multiple tasks are identified so that a unified protection mechanism can be applied to the resource. A user interface may be provided which enables the selection of a particular type of protection mechanism for the data in the resource. User supplied protection mechanisms may also be implemented.

Abstract: Embodiments can include computer-implemented methods or non-transitory computer readable media storing executable instructions. The method or instructions can perform execution scheduling for code generated from an executable graphical model, where the generated code is executed on a target. The method/instructions can perform execution scheduling for a first code portion having a first execution rate, and a second code portion having a second execution rate that is temporally related to the first execution rate. The execution scheduling can account for target environment characteristics obtained from a target, can use an execution schedule, and can account for optimizations related to the first code portion or the second code portion. The method/instructions can further schedule execution of the first code portion and the second code portion in generated executable code based on the performing.

Abstract: An embodiment can include one or more computer readable media storing executable instructions for performing execution scheduling for code generated from an executable graphical model. The media can store instructions for accessing a first code portion having a first priority, and a second code portion having a second priority, where the second priority has a relationship with the first priority. The media can store instructions for accessing target environment characteristics that indicate a performance of the target environment, and for performing execution scheduling for the first code portion and the second code portion, the execution scheduling taking into account the target environment characteristics, the execution scheduling using an execution schedule.

Abstract: An electric motor includes a stator, a rotor and an end cap. The stator includes a housing and magnets attached to an inner surface of the housing. The housing has an open end closed by the end cap. The rotor includes a shaft, an armature and a commutator fixed to the shaft. The end cap includes a cover case, a support plate integrally formed in the cover case, brushes, a bearing and a printed circuit board mounted in the cover case. The support plate divides the interior space of the cover case into a first cavity and a second cavity. The brushes are mounted in the first cavity, the bearing is mounted on the support plate, and the printed circuit board is mounted in the second cavity.

Abstract: A method and apparatus for monitoring during dynamic processes that determines when effective measurements of thermal effusivity and/or thermal conductivity can be made during a portion of a cycle during a calibration phase, then measures thermal effusivity and/or thermal conductivity during a subsequent dynamic process in dependence upon the time delay value and the measurement duration value until a desired value is obtained. A sensor having a measurement period of between one to two seconds allows monitoring of materials during dynamic processes such as tumbling, blending, mixing, and rocking. For example, measurements can be made until a value indicative of a desired mixture condition is obtained.

Abstract: A heat exchanger (10) is provided and in a highly preferred form is an EGR cooler (52) having first and second passes (56A,56B) that are connected to an inlet/outlet manifold (70) by a pair of corresponding thermal expansion joints (87,93) to allow differential thermal expansion between the various structural components of the heat exchanger (10).

Abstract: A method and apparatus for monitoring during dynamic processes that determines when effective measurements of thermal effusivity and/or thermal conductivity can be made during a portion of a cycle during a calibration phase, then measures thermal effusivity and/or thermal conductivity during a subsequent dynamic process in dependence upon the time delay value and the measurement duration value until a desired value is obtained. A sensor having a measurement period of between one to two seconds allows monitoring of materials during dynamic processes such as tumbling, blending, mixing, and rocking. For example, measurements can be made until a value indicative of a desired mixture condition is obtained.

Abstract: A heat exchanger (10) is provided and in a highly preferred form is an EGR cooler (52) having first and second passes (56A,56B) that are connected to an inlet/outlet manifold (70) by a pair of corresponding thermal expansion joints (87,93) to allow differential thermal expansion between the various structural components of the heat exchanger (10).

Abstract: When executing a graphical model of a dynamic system that includes two or more concurrently executing sets of operations, a processor is configured to create a first buffer and a second buffer within the executable graphical model. A first set of operations is configured to write data to the first buffer during a first execution instance of the first set of operations. The first set of operations is configured to write data to the second buffer during a second execution instance of the first thread. A second set of operations is configured to read the data from the first buffer during an instance of the second thread that executes contemporaneously with the second execution instance of the first set of operations. Determinations regarding access to the first buffer and second buffer by the first thread and second thread are self-contained within the first thread and second thread, respectively.

Abstract: A system for providing model level protection for resources holding data accessed by multiple tasks in a model is discussed. The protection occurs at the model level so that the protection mechanism does not interfere with model dynamics. Resources concurrently accessed by multiple tasks are identified so that a unified protection mechanism can be applied to the resource. A user interface may be provided which enables the selection of a particular type of protection mechanism for the data in the resource. User supplied protection mechanisms may also be implemented.