Abstract: The present invention provides a method for promoting functional cure of AIDS by reducing HIV reservoir with lenalidomide, the method including administering a therapeutically effective amount of lenalidomide to a patient. Also provided is a method for reducing intracellular P24 and cell-related HIV RNA in PBMCs derived from HIV patients in vitro with lenalidomide, including orally administering lenalidomide at 25 mg/d at days 1 to 21 in a 28-day cycle, and continuing ART for 48 weeks. Further provided is a method for inhibiting latent activator-induced activation of latent HIV cell line U1 with lenalidomide, including orally administering lenalidomide at 25 mg/d at days 1 to 21 in a 28-day cycle, and continuing ART for 48 weeks.

Abstract: The present invention provides a method for treating patients with cognitive dysfunction complicating HIV-associated CM with lenalidomide. Patients with HIV-associated CM develop IRIS, some of which develop cognitive dysfunction. The patients with HIV-associated CM-IRIS are diagnosed as having cognitive dysfunction by Chinese version of the Montreal Cognitive Assessment (MoCA) and International HIV Dementia Scale (IHDS). After the treatment with lenalidomide, the MoCA score and IHDS score of the patients are improved significantly, and the leukocyte, proteins, albumin, IgG and inflammatory cytokines (growth-related oncogene, interleukin [IL]-10, granulocyte-colony stimulating factor, IL-6, IL-8, complement factor H, tumor necrosis factor-?, and ?2 macroglobulin) in cerebrospinal fluid are greatly reduced.

Abstract: A washing machine includes a machine housing, a water accommodation tub disposed in the machine housing; a washing tub assembly disposed in the water accommodation tub and including a washing tub; and a balance ring mounted to an upper end of the washing tub and having a lower end fitted in the washing tub.

Abstract: A washing machine includes a machine housing, a water accommodation tub disposed in the machine housing; a washing tub assembly disposed in the water accommodation tub and including a washing tub; and a balance ring mounted to an upper end of the washing tub and having a lower end fitted in the washing tub.

Abstract: A method and system for use in a computing environment for selecting a subset of records from a set of records for placement of the subset of records in a plurality of destinations. A group of replica records is formed for a record of the subset of records, and a destination identification is assigned to each replica record, except one, of the group of replica records. A replica record associated with one of the plurality of destinations can be selected and can be placed in the associated destination.

Abstract: A method and system for use in a computing environment for selecting a subset of records from a set of records for placement of the subset of records in a plurality of destinations. A group of replica records is formed for a record of the subset of records, and a destination identification is assigned to each replica record, except one, of the group of replica records. A replica record associated with one of the plurality of destinations can be selected and can be placed in the associated destination.