Abstract: Disclosed is a method of preparing a drug-iodinated oil dispersion by high-pressure dissolution. In the invention, drug molecules are dissolved in and thoroughly mixed with iodinated oil under high pressure and rapid stirring. After the depressurization, the drug molecules are dispersed in the iodinated oil to prepare a uniformly-mixed drug-iodinated oil dispersion. The drug-iodinated oil dispersion prepared herein, compared to the drug-iodinated oil suspension and emulsion, has advantages of controllable morphology, long-term stability and slow drug-releasing rate, moreover, the drug molecules do not negatively affect the iodinated oil in physicochemical properties such as viscosity. In the liver cancer treatment, the prepared drug-iodinated oil dispersion is firstly injected through the hepatic arteries to perform the embolization, and the drug molecules are slowly released for a sustained treatment. The invention provides a good reference for the therapy combined with iodinated oil embolization.