Patents by Inventor Bibi F. CHOONARA

Bibi F. CHOONARA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Oral pharmaceutical dosage form for the delivery of a peptide and/or protein
    Patent number: 10973766
    Abstract: The invention relates to an oral polymeric pharmaceutical dosage form which comprises a thermoresponsive eutectic composition which is solid at or about room temperature and fluid at or about body temperature, the eutectic composition mixed together with a crosslinking agent and an active pharmaceutical ingredient (API) to form an API loaded region; and a porous polymeric composition at least partially surrounding the API loaded region to protect the API when the dosage form is in a stomach of the human or animal body, the porous polymeric composition allowing the ingress of water to contact the crosslinking agent thereby facilitating the crosslinking agent to cause crosslinking of the porous polymeric composition, which crosslinked porous polymeric composition allows controlled egress of API via egress of fluid thermoresponsive eutectic composition at the intestine. In a preferred embodiment, the dosage form further comprises a coating there around.
    Type: Grant
    Filed: June 27, 2016
    Date of Patent: April 13, 2021
    Assignee: UNIVERSITY OF THE WITWATERSRAND, JOHANNESBURG
    Inventors: Viness Pillay, Lisa Claire Du Toit, Yahya Essop Choonara, Bibi F. Choonara, Pradeep Kumar, Pierre Pavan Demarco Kondiah
  • AN ORAL PHARMACEUTICAL DOSAGE FORM FOR THE DELIVERY OF A PEPTIDE AND/OR PROTEIN
    Publication number: 20180193271
    Abstract: The invention relates to an oral polymeric pharmaceutical dosage form which comprises a thermoresponsive eutectic composition which is solid at or about room temperature and fluid at or about body temperature, the eutectic composition mixed together with a crosslinking agent and an active pharmaceutical ingredient (API) to form an API loaded region; and a porous polymeric composition at least partially surrounding the API loaded region to protect the API when the dosage form is in a stomach of the human or animal body, the porous polymeric composition allowing the ingress of water to contact the crosslinking agent thereby facilitating the crosslinking agent to cause crosslinking of the porous polymeric composition, which crosslinked porous polymeric composition allows controlled egress of API via egress of fluid thermoresponsive eutectic composition at the intestine. In a preferred embodiment, the dosage form further comprises a coating there around.
    Type: Application
    Filed: June 27, 2016
    Publication date: July 12, 2018
    Applicant: UNIVERSITY OF THE WITWATERSRAND, JOHANNESBURG
    Inventors: Viness PILLAY, Lisa Claire DU TOIT, Yahya Essop CHOONARA, Bibi F. CHOONARA, Pradeep KUMAR, Pierre Pavan Demarco KONDIAH