Patents by Inventor Biing-Jiun Uang

Biing-Jiun Uang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of enantioselective addition to imines
    Patent number: 9193743
    Abstract: The present invention relates to a method of enantioselective addition to imines, including: reacting R2CH?NY with R3ZnR4 in the presence of a compound represented by the following formula (I), in which Y, R1, R2, R3 and R4 are defined the same as the specification. Accordingly, the present invention can prepare secondary amines in high yields and enantiomeric excess by the above-mentioned method.
    Type: Grant
    Filed: December 18, 2014
    Date of Patent: November 24, 2015
    Assignee: NATIONAL TSING HUA UNIVERSITY
    Inventors: Biing-Jiun Uang, Wei-Ming Huang
  • METHOD OF ENANTIOSELECTIVE ADDITION TO IMINES
    Publication number: 20150183811
    Abstract: The present invention relates to a method of enantioselective addition to imines, including: reacting R2CH?NY with R3ZnR4 in the presence of a compound represented by the following formula (I), in which Y, R1, R2, R3 and R4 are defined the same as the specification. Accordingly, the present invention can prepare secondary amines in high yields and enantiomeric excess by the above-mentioned method.
    Type: Application
    Filed: December 18, 2014
    Publication date: July 2, 2015
    Inventors: Biing-Jiun UANG, Wei-Ming HUANG
  • Cathepsin S inhibitors
    Patent number: 8895497
    Abstract: Cathepsin S inhibitors having formula (I), (II), (III) or (IV) as shown in the specification. These inhibitors can be used to treat cancer and autoimmune/inflammatory diseases.
    Type: Grant
    Filed: December 6, 2010
    Date of Patent: November 25, 2014
    Assignees: DCB-USA, LLC, National Tsing Hua University, National Health Research Institutes
    Inventors: Chun-Cheng Lin, Wun-Shaing Wayne Chang, Biing-Jiun Uang, Jang-Yang Chang, Jo-Chun Chen, Hsing-Pang Hsieh
  • Method for preparing 2-morpholinoisobornane-10-thiol and intermediates formed therein
    Patent number: 8865893
    Abstract: A method for preparing 2-morpholinoisobornane-10-thiol is disclosed, which has simplified steps and avoids the use of Na metal. Accordingly, it is advantageous to apply the method in a mass production.
    Type: Grant
    Filed: October 8, 2010
    Date of Patent: October 21, 2014
    Assignee: National Tsing Hua University
    Inventors: Biing-Jiun Uang, Yu-Han Tsao, Ping-Yu Wu
  • Use of pterosin compounds for treating diabetes and obesity
    Patent number: 8633252
    Abstract: This invention relates to the use of pterosin compounds of formula I for treating diabetes including type I and type II. Also disclosed is the use of the pterosin compounds for treating obesity.
    Type: Grant
    Filed: January 26, 2010
    Date of Patent: January 21, 2014
    Assignees: Taipei Medical University, National Taiwan University, National Tsing Hua University, DCB-USA LLC
    Inventors: Feng-Lin Hsu, Shing-Hwa Liu, Biing-Jiun Uang
  • Camphor-derived compounds, method for manufacturing the same, and application thereof
    Patent number: 8609839
    Abstract: Camphor-derived compounds are disclosed, which are represented as the following formula (I): wherein R1, R2, R3, and R4 each are defined as described in the specification. In addition, a method for manufacturing the camphor-derived compounds and application thereof are disclosed.
    Type: Grant
    Filed: January 19, 2011
    Date of Patent: December 17, 2013
    Assignee: National Tsing Hua University
    Inventors: Biing-Jiun Uang, Bo-Yao Yang
  • Method of enantioselective addition to imines
    Patent number: 8461371
    Abstract: The present invention relates to a method of enantioselective addition to imines, including: reacting R3CH?NY with R4ZnR5 in the presence of a compound represented by the following formula (I), in which Y, R1, R2, R3, R4 and R5 are defined the same as the specification. Accordingly, the present invention can prepare secondary amines in high yields and enantiomeric excess by the above-mentioned method.
    Type: Grant
    Filed: October 6, 2010
    Date of Patent: June 11, 2013
    Assignee: National Tsing Hua University
    Inventors: Biing-Jiun Uang, Wei-Ming Huang
  • Camphor-derived ?-amino alcohol compounds, method for manufacturing the same and asymmetric addition of organozinc to aldehydes using the same
    Patent number: 8309715
    Abstract: A novel camphor-derived ?-amino alcohol compound is disclosed. The novel camphor-derived ?-amino alcohol compound can be used in asymmetric addition of organozinc to aromatic and aliphatic aldehydes, including linear aliphatic ones, thus generating corresponding secondary alcohols in high yields and enantiomeric excess.
    Type: Grant
    Filed: June 18, 2010
    Date of Patent: November 13, 2012
    Assignee: National Tsing Hua University
    Inventors: Biing-Jiun Uang, Chi-Rui Wu, Hsyueh-Liang Wu, Ping-Yu Wu
  • Method of enantioselective addition to enones
    Patent number: 8304581
    Abstract: The present invention relates to a method of enantioselective addition to enones, including: reacting R3(CH2)pCH?CR5C(?O)Y(CH2)qR4 with R6ZnR7 in the presence of a compound represented by the following formula (I) and a transition metal catalyst, in which Y, p, q, R1, R2, R3, R4, R5, R6 and R7 are defined the same as the specification. Accordingly, the present invention can perform asymmetric conjugate addition in high yields and enantioselectivity.
    Type: Grant
    Filed: July 19, 2010
    Date of Patent: November 6, 2012
    Assignee: National Tsing Hua University
    Inventors: Biing-Jiun Uang, Chih-Hao Tseng
  • Method for preparing propargylic alcohol catalyzed by 2-morpholinoisobornane-10-thiol
    Patent number: 8168835
    Abstract: A method for preparing a propargylic alcohol catalyzed by 2-morpholinoisobornane-10-thiol (MITH) is disclosed, which includes reacting R1CHO with R2CCH in the presence of R3ZnR4 and MITH, wherein each of R1, R2, R3, and R4, independently, is optionally substituted alkyl, alkenyl, cycloalkyl, cycloalkenyl, alkylsilyl, heterocycloalkyl, heterocycloalkenyl, aryl, aryloxy, or heteroaryl. The method can give enantioenriched propargylic alcohols with good enantioselective at low loading of MITH.
    Type: Grant
    Filed: May 26, 2010
    Date of Patent: May 1, 2012
    Assignee: National Tsing Hua University
    Inventors: Biing-Jiun Uang, Ping-Yu Wu, Hsyueh-Liang Wu
  • CAMPHOR-DERIVED COMPOUNDS, METHOD FOR MANUFACTURING THE SAME, AND APPLICATION THEREOF
    Publication number: 20120077976
    Abstract: Camphor-derived compounds are disclosed, which are represented as the following formula (I): wherein R1, R2, R3, and R4 each are defined as described in the specification. In addition, a method for manufacturing the camphor-derived compounds and application thereof are disclosed.
    Type: Application
    Filed: January 19, 2011
    Publication date: March 29, 2012
    Inventors: Biing-Jiun UANG, Bo-Yao Yang
  • METHOD OF ENANTIOSELECTIVE ADDITION TO IMINES
    Publication number: 20120004441
    Abstract: The present invention relates to a method of enantioselective addition to imines, including: reacting R3CH?NY with R4ZnR5 in the presence of a compound represented by the following formula (I), in which Y, R1, R2, R3, R4 and R5 are defined the same as the specification. Accordingly, the present invention can prepare secondary amines in high yields and enantiomeric excess by the above-mentioned method.
    Type: Application
    Filed: October 6, 2010
    Publication date: January 5, 2012
    Inventors: Biing-Jiun UANG, Wei-Ming Huang
  • CAMPHOR-DERIVED BETA-AMINO ALCOHOL COMPOUNDS, METHOD FOR MANUFACTURING THE SAME AND ASYMMETRIC ADDITION OF ORGANOZINC TO ALDEHYDES USING THE SAME
    Publication number: 20110313159
    Abstract: A novel camphor-derived ?-amino alcohol compound is disclosed. The novel camphor-derived ?-amino alcohol compound can be used in asymmetric addition of organozinc to aromatic and aliphatic aldehydes, including linear aliphatic ones, thus generating corresponding secondary alcohols in high yields and enantiomeric excess.
    Type: Application
    Filed: June 18, 2010
    Publication date: December 22, 2011
    Inventors: Biing-Jiun UANG, Chi-Rui Wu, Hsyueh-Liang Wu
  • METHOD FOR PREPARING PROPARGYLIC ALCOHOL CATALYZED BY 2-MORPHOLINOISOBORNANE-10-THIOL
    Publication number: 20110295042
    Abstract: A method for preparing a propargylic alcohol catalyzed by 2-morpholinoisobornane-10-thiol (MITH) is disclosed, which includes reacting R1CHO with R2CCH in the presence of R3ZnR4 and MITH, wherein each of R1, R2, R3, and R4, independently, is optionally substituted alkyl, alkenyl, cycloalkyl, cycloalkenyl, alkylsilyl, heterocycloalkyl, heterocycloalkenyl, aryl, aryloxy, or heteroaryl. The method can give enantioenriched propargylic alcohols with good enantioselective at low loading of MITH.
    Type: Application
    Filed: May 26, 2010
    Publication date: December 1, 2011
    Inventors: Biing-Jiun UANG, Ping-Yu Wu, Hsyueh-Liang Wu
  • METHOD OF ENANTIOSELECTIVE ADDITION TO ENONES
    Publication number: 20110282101
    Abstract: The present invention relates to a method of enantioselective addition to enones, including: reacting R3(CH2)pCH?CR5C(?O)Y(CH2)qR4 with R6ZnR7 in the presence of a compound represented by the following formula (I) and a transition metal catalyst, in which Y, p, q, R1, R2, R3, R4, R5, R6 and R7 are defined the same as the specification. Accordingly, the present invention can perform asymmetric conjugate addition in high yields and enantioselectivity.
    Type: Application
    Filed: July 19, 2010
    Publication date: November 17, 2011
    Inventors: Biing-Jiun UANG, Chih-Hao Tseng
  • CATHEPSIN S INHIBITORS
    Publication number: 20110166141
    Abstract: Cathepsin S inhibitors having formula (I), (II), (III) or (IV) as shown in the specification. These inhibitors can be used to treat cancer and autoimmune/inflammatory diseases.
    Type: Application
    Filed: December 6, 2010
    Publication date: July 7, 2011
    Applicants: DCB-USA, LLC, National Tsing Hua University, National Health Research Institutes
    Inventors: Chun-Cheng Lin, Wun-Shaing Wayne Chang, Biing-Jiun Uang, Jang-Yang Chang, Jo-Chun Chen, Hsing-Pang Hsieh
  • USE OF PTEROSIN COMPOUNDS FOR TREATING DIABETES AND OBESITY
    Publication number: 20100190732
    Abstract: This invention relates to the use of pterosin compounds of formula I for treating diabetes including type I and type II. Also disclosed is the use of the pterosin compounds for treating obesity.
    Type: Application
    Filed: January 26, 2010
    Publication date: July 29, 2010
    Applicants: Taipei Medical University, National Taiwan University, National Tsing Hua University, DCB-USA, LLC
    Inventors: Feng-Lin Hsu, Shing-Hwa Liu, Biing-Jiun Uang
  • Process for preparing optically active &agr;-hydroxy acids and derivatives thereof
    Patent number: 6639095
    Abstract: The present invention provides a process for preparing optically active &agr;-hydroxy acids and derivatives thereof by subjecting the alkylated 1,3-dioxolanones of formula (IV) wherein R1 and R2 are the same or different and are each independently H or C1-6 alkyl; R5 is H, C1-16 alkyl, or unsubstituted or substituted phenyl; and R6 is C1-8 alkyl, C2-7 alkenyl or unsubstituted or substituted benzyl, to either alcoholysis or hydrolysis, in which the alkylated 1,3-dioxolanones are obtained by using 10-camphorsulfonamide as a chiral auxiliary.
    Type: Grant
    Filed: October 8, 2002
    Date of Patent: October 28, 2003
    Inventors: Biing-Jiun Uang, Jia-Wen Chang, Der-Pin Jang
  • Chiral ligand and method for preparing cyanohydrins from aldehydes
    Patent number: 6258966
    Abstract: A chiral ligand of the formula (II) or formula (II′), was synthesized. The chiral ligand (II) or formula (II′) can chelate to metals to form a catalytic complex to catalyze the addition of trimethylsilyl cyanide to aldehydes to give optically active cyanohydrin, individually.
    Type: Grant
    Filed: October 13, 1999
    Date of Patent: July 10, 2001
    Assignee: Everlight USA, Inc.
    Inventors: Biing-Jiun Uang, Chun-Tzu Yang
  • Method for preparing 3-amino-1,2-propandiol derivatives
    Patent number: 6127537
    Abstract: A method for the preparation of 3-amino-1,2-propandiol derivatives of the formula (I) ##STR1## by reacting a compound of the formula (II) ##STR2## with RNH.sub.2, wherein R and R.sub.1 have the same meaning as given in the description. The formula (I) derivatives are .beta.-blockers used for treating hypertension.
    Type: Grant
    Filed: December 10, 1999
    Date of Patent: October 3, 2000
    Assignee: Everlight USA, Inc.
    Inventors: Biing-Jiun Uang, Jia-Wen Chang