Patents by Inventor Bijan Khirabadi

Bijan Khirabadi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of cryopreservation of tissues by vitrification
    Publication number: 20050100876
    Abstract: A method for vitrification of a tissue or organ includes immersing the tissue or organ in increasing concentrations of cryoprotectant solution at a temperature greater than ?15° C. to a cryoprotectant concentration sufficient for vitrification; cooling the tissue or organ at an average rate of from 2.5-100° C. per minute to a temperature between ?80° C. and the glass transition temperature; and further cooling the tissue or organ at an average rate less than 30° C. per minute to a temperature below the glass transition temperature to vitrify the tissue or organ. After the vitrified tissue or organ has been stored, the tissue or organ may be removed from vitrification by warming the tissue or organ at an average rate of from 20-40° C. per minute to a temperature between ?80° C. and the glass transition temperature; further warming the tissue or organ at a rate greater than 80° C. per minute to a temperature above ?75° C.; and reducing the concentration of the cryoprotectant.
    Type: Application
    Filed: August 25, 2003
    Publication date: May 12, 2005
    Applicant: ORGAN RECOVERY SYSTEMS, INC.
    Inventors: Bijan Khirabadi, Ying Song, Kelvin Brockbank
  • Method of preparing tissues for vitrification
    Publication number: 20010031459
    Abstract: The invention relates to the field of organ and tissue perfusion. More particularly, the present invention relates to a method for preparing organs, such as the kidney and liver, for cryopreservation through the introduction of vitrifiable concentrations of cryoprotectant into them. To prepare the organ for cryopreservation, the donor human or animal, is treated in the usual manner and may also be treated with iloprost, or other vasodilators, and/or transforming growth factor &bgr;1. Alternatively, or additionally, the organ which is to be cryopreserved can be administered iloprost, or other vasodilators, and/or transforming growth factor &bgr;1 directly into its artery. The invention also relates to preparing organs for transplantation by a method for the removal of the cryoprotectant therefrom using low (such as raffinose, sucrose, mannitol, etc.
    Type: Application
    Filed: January 12, 2001
    Publication date: October 18, 2001
    Applicant: THE AMERICAN NATIONAL RED CROSS
    Inventors: Gregory Fahy, Bijan Khirabadi, Yasumitsu Okouchi, Thomas Maciag
  • Method for preparing organs for transplantation after cryopreservation
    Patent number: 6187529
    Abstract: The invention relates to the field of organ and tissue perfusion. More particularly, the present invention relates to a method for preparing organs, such as the kidney and liver, for cryopreservation through the introduction of vitrifiable concentrations of cryoprotectant into them. To prepare the organ for cryopreservation, the donor human or animal, is treated in the usual manner and may also be treated with iloprost, or other vasodilators, and/or transforming growth factor &bgr;1. Alternatively, or additionally, the organ which is to be cryopreserved can be administered iloprost, or other vasodilators, and/or transforming growth factor &bgr;1 directly into its artery. The invention also relates to preparing organs for transplantation by a method for the removal of the cryoprotectant therefrom using low (such as raffinose, sucrose, mannitol, etc.
    Type: Grant
    Filed: April 28, 1998
    Date of Patent: February 13, 2001
    Assignee: The American National Red Cross
    Inventors: Gregory M. Fahy, Bijan Khirabadi, Yasumitsu Okouchi, Thomas Maciag
  • Method of preparing tissues and cells for vitrification
    Patent number: 5962214
    Abstract: The invention relates to the field of organ and tissue perfusion. More particularly, the present invention relates to a method for preparing organs, such as the kidney and liver, for cryopreservation through the introduction of vitrifiable concentrations of cryoprotectant into them. To prepare the organ for cryopreservation, the donor human or animal, is treated in the usual manner and may also be treated with iloprost, or other vasodilators, and/or transforming growth factor .beta.1. Alternatively, or additionally, the organ which is to be cryopreserved can be administered iloprost, or other vasodilators, and/or transforming growth factor .beta.1 directly into its artery. The invention also relates to preparing organs for transplantation by a method for the removal of the cryoprotectant therefrom using low (such as raffi nose, sucrose, mannitol, etc.
    Type: Grant
    Filed: February 27, 1998
    Date of Patent: October 5, 1999
    Assignee: The United States of America as represented by The American National Red Cross
    Inventors: Gregory M. Fahy, Bijan Khirabadi, Yasumitsu Okouchi, Thomas Maciag
  • Methods for removal of cryoprotectant from organs prior to transplantation
    Patent number: 5821045
    Abstract: The invention relates to the field of organ and tissue perfusion. More particularly, the present invention relates to a method for preparing organs, such as the kidney and liver, for cryopreservation through the introduction of vitrifiable concentrations of cryoprotectant into them. To prepare the organ for cryopreservation, the donor human or animal, is treated in the usual manner and may also be treated with iloprost, or other vasodilators, and/or transforming growth factor .beta.1. Alternatively, or additionally, the organ which is to be cryopreserved can be administered iloprost, or other vasodilators, and/or transforming growth factor .beta.1 directly into its artery. The invention also relates to preparing organs for transplantation by a method for the removal of the cryoprotectant therefrom using low (such as raffinose, sucrose, mannitol, etc.
    Type: Grant
    Filed: May 31, 1995
    Date of Patent: October 13, 1998
    Assignee: The American National Red Cross
    Inventors: Gregory M. Fahy, Bijan Khirabadi, Yasumitsu Okouchi
  • Method of preparing organs for vitrification
    Patent number: 5723282
    Abstract: The invention relates to the field of organ and tissue perfusion. More particularly, the present invention relates to a method for preparing organs, such as the kidney and liver, for cryopreservation through the introduction of vitrifiable concentrations of cryoprotectant into them. To prepare the organ for cryopreservation, the donor human or animal, is treated in the usual manner and may also be treated with iloprost, or other vasodilators, and/or transforming growth factor .beta.1. Alternatively, or additionally, the organ which is to be cryopreserved can be administered iloprost, or other vasodilators, and/or transforming growth factor .beta.1 directly into its artery. The invention also relates to preparing organs for transplantation by a method for the removal of the cryoprotectant therefrom using low (such as raffinose, sucrose, mannitol, etc.
    Type: Grant
    Filed: August 18, 1994
    Date of Patent: March 3, 1998
    Assignee: The American National Red Cross
    Inventors: Gregory M. Fahy, Bijan Khirabadi, Yasumitsu Okouchi, Thomas Maciag